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CDH17

CDH17指的是膽固醇黏附素家族成員17(Cadherin-17),也被稱為肝臟細(xì)胞間粘附分子(Liver-Cell Adhesion Molecule,L-CAM)。它是一種單個(gè)跨膜的細(xì)胞粘附分子,屬于鈣依賴性細(xì)胞粘附分子家族中的一員。CDH17主要在肝、膽管、胰腺、消化道和泌尿道等組織中表達(dá)。 CDH17的主要功能是調(diào)節(jié)細(xì)胞黏附、遷移和生長(zhǎng)等過程,參與了多種生理和病理過程。例如,在肝膽系統(tǒng)中,CDH17發(fā)揮了肝細(xì)胞和膽管上皮細(xì)胞之間的黏附作用,同時(shí)還參與了膽汁酸的轉(zhuǎn)運(yùn)和分泌。在胰腺癌中,CDH17的高表達(dá)與腫瘤的浸潤(rùn)和轉(zhuǎn)移有關(guān)。 因此,CDH17已成為潛在的治療靶點(diǎn),CUSABIO有多種CDH17單克隆抗體供您選擇。

更多相關(guān)閱讀:腸鈣粘蛋白CDH17:?jiǎn)慰?、雙抗、CAR T“多管齊下”,胃腸道癌GIC重磅靶點(diǎn)!

熱銷產(chǎn)品

Recombinant Human Cadherin-17(CDH17),partial (Active) CSB-MP613267HU

驗(yàn)證數(shù)據(jù)

High Purity Validated by SDS-PAGE
CSB-MP613267HU SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Excellent Bioactivity Validated by Functional ELISA
CSB-MP613267HU AC

Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CDH17 at 2μg/mL can bind Anti-CDH17 recombinant antibody (CSB-RA613267MA1HU), the EC50 is 3.095 to 4.451 ng/mL.

CDH17 Recombinant Monoclonal Antibody CSB-RA613267MA1HU

驗(yàn)證數(shù)據(jù)

Excellent Bioactivity Validated by Functional ELISA
CSB-RA613267MA1HU ELISA

The Binding Activity of Human CDH17 with Anti-CDH17 Recombinant Antibody

Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CDH17 (CSB-MP613267HU) at 2 μg/mL can bind Anti-CDH17 recombinant antibody, the EC50 is 3.095-4.451 ng/mL.

FC
CSB-MP613267HU FC

Untransfected HEK293T cells (green line) and transfected Human CDH17 HEK293T stable cells (red line) were stained with anti-CDH17 antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CDH17 Antibodies

CDH17 for Homo sapiens (Human)

CDH17 Proteins

CDH17 Proteins for Rattus norvegicus (Rat)

CDH17 Proteins for Homo sapiens (Human)

CDH17 Proteins for Mus musculus (Mouse)