CD147
CD147,(也稱為Basigin或EMMPRIN),是一種跨膜蛋白,屬于免疫球蛋白超家族,其結(jié)構(gòu)含有一個(gè)細(xì)胞外N端和一個(gè)胞內(nèi)C端。它有一個(gè)Ig-like(免疫球蛋白樣)細(xì)胞外結(jié)構(gòu)域,可與其他蛋白質(zhì)發(fā)生相互作用。CD147廣泛表達(dá)在許多細(xì)胞類型中,包括免疫細(xì)胞、白血球、紅血球、神經(jīng)細(xì)胞、膠質(zhì)細(xì)胞、腫瘤細(xì)胞等。它在細(xì)胞間黏附和遷移過(guò)程中發(fā)揮重要作用,并參與多種生物學(xué)過(guò)程,如細(xì)胞的增殖、侵襲、轉(zhuǎn)移以及免疫細(xì)胞的活化和炎癥反應(yīng)等。 在腫瘤學(xué)中,CD147被認(rèn)為是一種腫瘤相關(guān)標(biāo)志物,因?yàn)樗诙喾N腫瘤細(xì)胞表面的表達(dá)水平明顯升高,與腫瘤細(xì)胞的侵襲和轉(zhuǎn)移有關(guān)。CD147還參與調(diào)節(jié)腫瘤微環(huán)境中的細(xì)胞間相互作用,對(duì)腫瘤的生長(zhǎng)和進(jìn)展具有一定的影響。此外,CD147在免疫調(diào)節(jié)和感染過(guò)程中也發(fā)揮著重要作用。它與病原體感染、炎癥反應(yīng)和免疫細(xì)胞的活化和遷移等過(guò)程密切相關(guān)。是疾病治療和新藥開(kāi)發(fā)的潛在靶點(diǎn)。
熱銷產(chǎn)品
● Recombinant Human Basigin(BSG),partial (Active)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized CD147 at 2 μg/ml can bind Anti-CD147 recombinant Antibody, the EC50 is 21.95-33.12 ng/ml.
● CD147 Recombinant Monoclonal Antibody CSB-RA002831A0HU
驗(yàn)證數(shù)據(jù)
Positive WB detected in: HepG2 whole cell lysate, ntera2 whole cell lysate, A549 whole cell lysate, U251 whole cell lysate
All lanes: CD147 antibody at 1:1000
Secondary
Goat polyclonal to mouse IgG at 1/50000 dilution
Predicted band size: 42, 29, 23, 19 KDa
Observed band size: 35, 50-60 KDa
CD147 Antibodies
CD147 for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA11759A0Rb | BSG Antibody | Human | ELISA, WB, IHC |
CSB-PA11759C0Rb | BSG Antibody, FITC conjugated | Human | |
CSB-PA002831GA01HU | BSG Antibody | Human | ELISA,WB,IHC |
CSB-PA11759B0Rb | BSG Antibody, HRP conjugated | Human | ELISA |
CSB-PA11759D0Rb | BSG Antibody, Biotin conjugated | Human | ELISA |
CSB-PA002331 | BSG Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA005853 | BSG Antibody | Human | WB, ELISA |
CSB-PA993569 | BSG Antibody | Human | ELISA,IHC |
CSB-PA570608 | BSG Antibody | Human | ELISA,WB,IHC |
CSB-RA002831A0HU | CD147 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, IF, FC |
CD147 Proteins
CD147 Proteins for Mus musculus (Mouse)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
---|---|---|
CSB-YP002831MO1 CSB-EP002831MO1 CSB-BP002831MO1 CSB-MP002831MO1 CSB-EP002831MO1-B |
Recombinant Mouse Basigin (Bsg), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF002831MO | Recombinant Mouse Basigin (Bsg) | in vitro E.coli expression system |
CD147 Proteins for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
---|---|---|
CSB-YP002831HU CSB-EP002831HU CSB-BP002831HU CSB-EP002831HU-B |
Recombinant Human Basigin (BSG), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSB-RP117574h | Recombinant Human Basigin (BSG), partial | E.coli |
CSB-CF002831HU | Recombinant Human Basigin (BSG) | in vitro E.coli expression system |
CSB-MP002831HU | Recombinant Human Basigin (BSG), partial | Mammalian cell |
CSB-MP002831HUf3 | Recombinant Human Basigin (BSG), partial | Mammalian cell |
CSB-MP002831HU1 | Recombinant Human Basigin (BSG), partial (Active) | Mammalian cell |
CD147 Proteins for Rattus norvegicus (Rat)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
---|---|---|
CSB-YP002831RA1 CSB-EP002831RA1 CSB-BP002831RA1 CSB-MP002831RA1 CSB-EP002831RA1-B |
Recombinant Rat Basigin (Bsg), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF002831RA | Recombinant Rat Basigin (Bsg) | in vitro E.coli expression system |
CD147 Proteins for Oryctolagus cuniculus (Rabbit)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
---|---|---|
CSB-YP631727RB CSB-EP631727RB CSB-BP631727RB CSB-MP631727RB CSB-EP631727RB-B |
Recombinant Rabbit Basigin (BSG), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD147 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
---|---|---|
CSB-YP857519DXU CSB-EP857519DXU CSB-BP857519DXU CSB-MP857519DXU CSB-EP857519DXU-B |
Recombinant Cricetulus griseus Basigin (BSG), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD147 ELISA Kit
CD147 ELISA Kit for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
---|---|---|---|
CSB-E12994h | Human Cluster of differentiation 147,CD147 Elisa Kit | serum, plasma | 3.12 pg/mL |