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AGT

AGT,即血管緊張素原,別名Angiotensinogen、ANHU、ANRT、AT-2。它是腎素-血管緊張素-醛固酮系統(tǒng)(RAAS)的關(guān)鍵組分,由AGT基因編碼,在肝臟中合成。它通過腎素作用轉(zhuǎn)化為血管緊張素I,再經(jīng)血管緊張素轉(zhuǎn)換酶(ACE)作用生成血管緊張素II,參與調(diào)節(jié)血壓和體內(nèi)電解質(zhì)平衡。AGT的異常表達(dá)與高血壓、子癇前期等疾病相關(guān),其功能異??赡軐?dǎo)致腎小管發(fā)育不良等病癥。RNAi療法ALN-AGT針對AGT,可能變革高血壓治療,通過減少給藥頻率提高患者依從性,具有重要的臨床應(yīng)用前景。

熱銷產(chǎn)品

Recombinant Human Angiotensinogen (AGT), partial (CSB-EP001463HU1)

驗證數(shù)據(jù)

CSB-EP001463HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

AGT Recombinant Monoclonal Antibody (CSB-RA263831A0HU)

驗證數(shù)據(jù)

CSB-RA263831A0HU

IHC image of CSB-RA263831A0HU diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Human angiotensinogen (aGT) ELISA Kit (CSB-E08564h)

驗證數(shù)據(jù)

CSB-E08564h 標(biāo)準(zhǔn)曲線

貨號:CSB-E08564h

規(guī)格:96T/48T

靈敏度:19.5 pg/mL

檢測范圍:78 pg/mL-5000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

AGT Antibodies

AGT for Homo sapiens (Human)

AGT Proteins

AGT Proteins for Gallus gallus (Chicken)

AGT Proteins for Mus musculus (Mouse)

AGT Proteins for Ovis aries (Sheep)

AGT Proteins for Homo sapiens (Human)

AGT Proteins for Rattus norvegicus (Rat)

AGT Proteins for Equus caballus (Horse)

AGT Proteins for Bos taurus (Bovine)

AGT Proteins for Coturnix coturnix japonica (Japanese quail) (Coturnix japonica)

AGT Proteins for Enterobacteria phage T4 (Bacteriophage T4)

AGT Proteins for Pan troglodytes (Chimpanzee)

AGT Proteins for Gorilla gorilla gorilla (Lowland gorilla)

AGT Proteins for Callithrix jacchus (White-tufted-ear marmoset)

AGT ELISA Kit

AGT ELISA Kit for Homo sapiens (Human)

AGT ELISA Kit for Mus musculus (Mouse)

AGT ELISA Kit for Rattus norvegicus (Rat)