細(xì)胞因子是一類在細(xì)胞間傳遞信號(hào)的蛋白質(zhì)，參與調(diào)節(jié)免疫反應(yīng)、細(xì)胞生長、細(xì)胞分化等多種生理過程。由于其在生物體內(nèi)的多功能性，細(xì)胞因子在疾病的發(fā)生、發(fā)展和治療中扮演著非常重要的角色。
圖1. 生成細(xì)胞因子的主要細(xì)胞類型 [1]
*圖片來源于International Journal of Molecular Sciences的出版物
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細(xì)胞因子抗體能夠特異性識(shí)別并結(jié)合到細(xì)胞因子的特定表位，是研究細(xì)胞因子功能和信號(hào)傳導(dǎo)途徑的重要工具。在藥物開發(fā)階段，細(xì)胞因子抗體可以作為藥物候選分子，或用于開發(fā)針對特定細(xì)胞因子的靶向治療；在臨床前研究階段，細(xì)胞因子抗體可用于檢測特定細(xì)胞因子的水平，作為創(chuàng)建疾病模型、驗(yàn)證治療靶點(diǎn)、研究細(xì)胞因子相互作用和開發(fā)新療法的關(guān)鍵工具。
華美生物所開發(fā)的細(xì)胞因子抗體系列產(chǎn)品涵蓋了廣泛的細(xì)胞因子靶點(diǎn)，包含單克隆抗體和多克隆抗體，并經(jīng)過Western Blot、免疫組化、免疫熒光和流式細(xì)胞術(shù)等多重驗(yàn)證，可滿足不同研究和應(yīng)用需求。
特色產(chǎn)品
產(chǎn)品目錄
● 重組抗體：
| 產(chǎn)品名稱 | 貨號(hào) | 反應(yīng)種屬 | 應(yīng)用范圍 |
|---|---|---|---|
| BMP4 Recombinant Monoclonal Antibody | CSB-RA257673A0HU | Human | ELISA, WB, IF |
| CCL19 Recombinant Monoclonal Antibody | CSB-RA859522A0HU | Human | ELISA, IHC |
| CXCL10 Recombinant Monoclonal Antibody | CSB-RA903061A0HU | Human | ELISA, IHC |
| EBI3 Recombinant Monoclonal Antibody | CSB-RA256644A0HU | Human | ELISA, WB |
| GDF15 Recombinant Monoclonal Antibody | CSB-RA285852A0HU | Human | ELISA, IHC |
| GPI Recombinant Monoclonal Antibody | CSB-RA130853A0HU | Human | ELISA, WB, IHC, FC |
| IL10 Recombinant Monoclonal Antibody | CSB-RA011580A0HU | Human | ELISA |
| IL12B Recombinant Monoclonal Antibody | CSB-RA895985A0HU | Human | ELISA, FC |
| IL17A Recombinant Monoclonal Antibody | CSB-RA624104MA1HU | Human | ELISA |
| IL23A Recombinant Monoclonal Antibody | CSB-RA251959A0HU | Human | ELISA, WB |
| IL4 Recombinant Monoclonal Antibody | CSB-RA240377A0HU | Human | ELISA, IHC |
| IL6 Recombinant Monoclonal Antibody | CSB-RA011664MA1HU | Human | ELISA |
| IL8 Recombinant Monoclonal Antibody | CSB-RA582227A0HU | Human | ELISA, FC |
| LEFTY2 Recombinant Monoclonal Antibody | CSB-RA171603A0HU | Human | ELISA, WB |
| LTA Recombinant Monoclonal Antibody | CSB-RA013218A0HU | Human | ELISA |
| MIF Recombinant Monoclonal Antibody | CSB-RA146975A0HU | Human | ELISA, WB |
| OSM Recombinant Monoclonal Antibody | CSB-RA017260MA1HU | Human | ELISA |
| SPP1 Recombinant Monoclonal Antibody | CSB-RA261140A0HU | Human | ELISA, WB, IHC |
| SPP1 Recombinant Monoclonal Antibody | CSB-RA022603MA1HU | Human | ELISA, FC |
| TSLP Recombinant Monoclonal Antibody | CSB-RA025141A1HU | Human | ELISA |
● 單克隆抗體：
| 產(chǎn)品名稱 | 貨號(hào) | 反應(yīng)種屬 | 應(yīng)用范圍 |
|---|---|---|---|
| CCL2 Monoclonal Antibody | CSB-MA058641A0m | Human | ELISA, IHC |
| CXCL8 Monoclonal Antibody | CSB-MA083271A0m | Human | ELISA, IHC |
| GDF15 Monoclonal Antibody | CSB-MA999881A0m | Human | ELISA, IHC |
| IFNG Monoclonal Antibody | CSB-MA065241A0m | Human | ELISA, IHC |
| IL1B Monoclonal Antibody | CSB-MA065741A0m | Human | ELISA |
| IL1B Monoclonal Antibody | CSB-MA010884 | Human | ELISA, WB, IHC, ICC |
| IL1F10 Monoclonal Antibody | CSB-MA8378691A0m | Human | ELISA, IHC |
| IL6 Monoclonal Antibody | CSB-MA067571A0m | Human | ELISA, WB, IHC |
| SPP1 Monoclonal Antibody | CSB-MA069021A0m | Human | ELISA, WB, IHC |
| TNF Monoclonal Antibody | CSB-MA084771A0m | Bovine | ELISA |
| TNF Monoclonal Antibody | CSB-MA080271 | Human,Mouse,Rat | ELISA, WB, IHC |
| TNF Monoclonal Antibody | CSB-MA080272 | Human,Mouse,Rat | ELISA, WB, IHC |
● 多克隆抗體：
| 產(chǎn)品名稱 | 貨號(hào) | 反應(yīng)種屬 | 應(yīng)用范圍 |
|---|---|---|---|
| AIMP1 Antibody | CSB-PA618638DSR1HU | Human | ELISA, WB, IHC, IP |
| AIMP1 Antibody | CSB-PA618638EA01HU | Human | ELISA, WB, IHC, IF |
| AIMP1 Antibody | CSB-PA006313 | Human | ELISA, WB |
| AIMP1 Antibody | CSB-PA020871GA01HU | Human, Mouse, Rat | ELISA, WB, IHC |
| AIMP1 Antibody | CSB-PA584418 | Human, Mouse | ELISA, WB, IHC |
| AIMP1 Antibody | CSB-PA181130 | Human, Mouse | ELISA, WB, IHC |
| AREG Antibody | CSB-PA11339A0Rb | Human | ELISA, IHC, IF |
| AREG Antibody | CSB-PA006314 | Human | ELISA, WB |
| AREG Antibody | CSB-PA001986GA01HU | Human | ELISA, WB, IHC, IF |
| AREG Antibody | CSB-PA441346 | Human | ELISA, WB |
| AREG Antibody | CSB-PA694774 | Human | ELISA, WB |
| BMP1 Antibody | CSB-PA910353 | Human, Mouse, Rat | ELISA, IHC |
| BMP10 Antibody | CSB-PA002734LA01HU | Human | ELISA, IHC |
| BMP10 Antibody | CSB-PA008875 | Human | ELISA, WB |
| BMP10 Antibody | CSB-PA199182 | Human, Mouse, Rat | ELISA, WB |
| BMP10 Antibody | CSB-PA198870 | Human | ELISA, WB |
| BMP15 Antibody | CSB-PA002735ESR1HU | Human | ELISA, IHC |
| BMP15 Antibody | CSB-PA006330 | Human | ELISA, WB |
| BMP15 Antibody | CSB-PA192471 | Human | ELISA, WB, IHC |
| BMP15 Antibody | CSB-PA055744 | Human | ELISA, WB, IHC |
已發(fā)表文獻(xiàn)（部分）
[1] Vitamin D 3 exacerbates steatosis while calcipotriol inhibits inflammation in non-alcoholic fatty liver disease in Sod1 knockout mice: a comparative study of two forms of vitamin D. Food Funct, 2024 Apr 22.
華美助力產(chǎn)品：TNF Antibody, CSB-PA07427A0Rb
[2] Macrophage Inflammatory Proteins (MIPs) Contribute to Malignant Potential of Colorectal Polyps and Modulate Likelihood of Cancerization Associated with Standard Risk Factors. Int J Mol Sci. 2024 Jan 23.
華美助力產(chǎn)品：CCL3 Antibody, CSB-PA040299; CCL23 Antibody, CSB-PA962305
[3] Impact of 10-day bed rest on serum levels of irisin and markers of musculoskeletal metabolism. FASEB J. 2023 01
華美助力產(chǎn)品：MSTN Antibody, CSB-PA11869A0Rb
[4] The LINC00152/miR-205-5p/CXCL11 axis in hepatocellular carcinoma cancer-associated fibroblasts affects cancer cell phenotypes and tumor growth. Cell Oncol (Dordr). 2022 Dec.
華美助力產(chǎn)品：CXCL11 Antibody, CSB-PA06119A0Rb
[5] Anti-PD-L1 antibody enhances curative effect of cryoablation via antibody-dependent cell-mediated cytotoxicity mediating PD-L1 high CD11b + cells elimination in hepatocellular carcinoma. Acta Pharm Sin B. 2023 Feb.
華美助力產(chǎn)品：Cxcl9 Antibody, CSB-PA09269A0Rb
參考文獻(xiàn)：
[1] Kany S, Vollrath J T, Relja B. Cytokines in Inflammatory Disease [J]. International Journal of Molecular Sciences, 2019, 20(23):6008.
