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重組抗體

產(chǎn)品名稱 貨號(hào) 規(guī)格
CCNE1 Recombinant Monoclonal Antibody CSB-RA968740A0HU 100μl/50μl
FCGR2A Recombinant Monoclonal Antibody CSB-RA163349A0HU 100μl/50μl
VDR Recombinant Monoclonal Antibody CSB-RA945260A0HU 100μl/50μl
CD22 Recombinant Monoclonal Antibody CSB-RA962691A0HU 100μl/50μl
RBBP4 Recombinant Monoclonal Antibody CSB-RA915915A0HU 100μl/50μl
ALDH2 Recombinant Monoclonal Antibody CSB-RA799763A0HU 100μl/50μl
SELPLG Recombinant Monoclonal Antibody CSB-RA567010A0HU 100μl/50μl
CASP3 Recombinant Monoclonal Antibody CSB-RA241798A0HU 100μl/50μl
CD27 Recombinant Monoclonal Antibody CSB-RA953976A0HU 100μl/50μl
INSR Recombinant Monoclonal Antibody CSB-RA155156A0HU 100μl/50μl
LPAR1 Recombinant Monoclonal Antibody CSB-RA922556A0HU 100μl/50μl
PDE4D Recombinant Monoclonal Antibody CSB-RA996952A0HU 100μl/50μl
FLI1 Recombinant Monoclonal Antibody CSB-RA207775A0HU 100μl/50μl
NOTCH1 Recombinant Monoclonal Antibody CSB-RA599445A0HU 100μl/50μl
MAPKAPK2 Recombinant Monoclonal Antibody CSB-RA951792A0HU 100μl/50μl
MAPKAPK2 Recombinant Monoclonal Antibody CSB-RA990134A0HU 100μl/50μl
CYP17A1 Recombinant Monoclonal Antibody CSB-RA554990A0HU 100μl/50μl
DRD3 Recombinant Monoclonal Antibody CSB-RA929304A0HU 100μl/50μl
GABRA5 Recombinant Monoclonal Antibody CSB-RA559038A0HU 100μl/50μl
HIF1A Recombinant Monoclonal Antibody CSB-RA263943A0HU 100μl/50μl

關(guān)于重組抗體

與傳統(tǒng)抗體相比,重組抗體的優(yōu)勢(shì)具體如下:

  • 更高的一致性和重復(fù)性

    因?yàn)橹亟M抗體是由一組獨(dú)特的基因發(fā)展而來(lái)的,所以抗體生產(chǎn)是可控且可靠的??梢员苊怆s交瘤細(xì)胞制備中的一些問(wèn)題,如基因丟失、基因突變和細(xì)胞株漂移等。這使得抗體的批次間差異非常小,從而為您提供高度可重復(fù)的結(jié)果。

  • 更高的靈敏度和特異性

    利用重組技術(shù),更容易通過(guò)抗體工程提高抗體特異性和靈敏度。所需克隆的選擇過(guò)程發(fā)生在雜交瘤細(xì)胞和重組克隆階段,這使我們能夠選擇最優(yōu)的抗體質(zhì)量。

  • 易于擴(kuò)展

    隨著抗體基因的分離,與傳統(tǒng)單克隆技術(shù)相比,抗體表達(dá)能夠以任何規(guī)模在更短的時(shí)間內(nèi)進(jìn)行。這意味著我們可以在數(shù)周而非數(shù)月內(nèi)產(chǎn)生定制抗體。

  • 無(wú)動(dòng)物高通量生產(chǎn)

    一旦分離出產(chǎn)生抗體的基因,就可以實(shí)現(xiàn)無(wú)動(dòng)物體外生產(chǎn)。

重組抗體與傳統(tǒng)抗體的比較:

單克隆抗體 多克隆抗體 重組抗體
重復(fù)性 高;批次間差異小 更高;高純度,批次間差異更小
特異性 強(qiáng) 更強(qiáng)
生產(chǎn)周期 4到6個(gè)月的開發(fā);4到6周的生產(chǎn) 2到3個(gè)月的開發(fā)和生產(chǎn) 4個(gè)月的開發(fā);1到6周的生產(chǎn)
同型亞基轉(zhuǎn)換 困難 困難 方便
表達(dá)系統(tǒng) 小鼠腹水法和體外方法 通常在哺乳動(dòng)物細(xì)胞(如兔) 通常在哺乳動(dòng)物細(xì)胞系中,也可在特殊工程細(xì)胞系中表達(dá),如酵母、細(xì)菌、昆蟲和轉(zhuǎn)基因植物
成本 生產(chǎn)成本較高;需要更專業(yè)的人員操作 成本相對(duì)較低 需要技術(shù)專長(zhǎng)和較大的時(shí)間和金錢投入進(jìn)行生產(chǎn)
人類免疫應(yīng)答 無(wú)法避免 無(wú)法避免 可避免

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引用文獻(xiàn)

S Antibody referenced in "A magneto-optical biochip for rapid assay based on the Cotton–Mouton effect of γ-Fe2O3@ Au core/shell nanoparticles", Journal of nanobiotechnology, 2021.

SARS-CoV-2 Spike RBD Nanobody referenced in "Potent antiviral activity of Agrimonia pilosa, Galla rhois, and their components against SARS-CoV-2", Bioorganic & Medicinal Chemistry, 2021.

HIF1A Antibody, CASP3 Antibody referenced in "PESV represses non-small cell lung cancer cell malignancy through circ_0016760 under hypoxia", Cancer cell international, 2021.

Phospho-ERN1 (S724) Antibody referenced in "The ER stress sensor inositol-requiring enzyme 1α in Kupffer cells promotes hepatic ischemia-reperfusion injury", Journal of Biological Chemistry, 2021.

CDK4 Antibody and CDK6 Antibody referenced in "Histone Deacetylase Inhibitor-Induced CDKN2B and CDKN2D Contribute to G2/M Cell Cycle Arrest Incurred by Oxidative Stress in Hepatocellular Carcinoma Cells Via Forkhead Box M1 Suppression", Journal of Cancer, 2021.

BIRC5 Antibody referenced in "LTBP4 Inhibits the Proliferation and Metastasis in Melanoma by Activating Hippo-YAP Signaling", Research Square, 2020.

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