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Recombinant Rat B2 bradykinin receptor (Bdkrb2)

  • 中文名稱：
    Recombinant Rat B2 bradykinin receptor(Bdkrb2)
  • 貨號：
    CSB-CF002652RA
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
    Bdkrb2
  • Uniprot No.：
  • 別名：
    Bdkrb2; B2 bradykinin receptor; B2R; BK-2 receptor
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-396
  • 氨基酸序列
    MDTRSSLCPKTQAVVAVFWGPGCHLSTCIEMFNITTQALGSAHNGTFSEVNCPDTEWWSWLNAIQAPFLWVLFLLAALENIFVLSVFCLHKTNCTVAEIYLGNLAAADLILACGLPFWAITIANNFDWLFGEVLCRVVNTMIYMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWSCTLLLSSPMLVFRTMKDYREEGHNVTACVIVYPSRSWEVFTNMLLNLVGFLLPLSIITFCTVRIMQVLRNNEMKKFKEVQTEKKATVLVLAVLGLFVLCWFPFQISTFLDTLLRLGVLSGCWNERAVDIVTQISSYVAYSNSCLNPLVYVIVGKRFRKKSREVYQAICRKGGCMGESVQMENSMGTLRTSISVDRQIHKLQDWAGNKQ
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
  • 基因功能參考文獻(xiàn)：
    1. Findings suggest that bradykinin 1 receptor and bradykinin 2 receptor have detrimental and beneficial effects, respectively in diabetic cerebral ischaemia. PMID: 26565562
    2. Up-regulation of the kinin B2 receptor pathway modulates the TGF-beta/Smad signaling cascade to reduce renal fibrosis induced by albumin. PMID: 26256678
    3. These results indicate that B2R couples with P2Y2R and that these G-protein-coupled receptors act together to fine-tune cellular responsiveness. PMID: 25713410
    4. B2R signaling may regulate monocyte/macrophage infiltration and c-Jun signals in the irradiated heart. Although eNOS is a main target for kinins, the B2R may not regulate eNOS phosphorylation in response to radiation. PMID: 25955317
    5. bradykinin receptor B1 may participate in apoptotic cell death signalling, and bradykinin receptor B2 may be involved in necrotic cell death PMID: 24724708
    6. Data indicate that ANO1 channels form signaling complexes with IP3 receptor (IP3R1) and GPCRs bradykinin receptor 2 (B2R) and protease-activated receptor 2 (PAR-2). PMID: 23982204
    7. The neuroprotective feature of bradykinin stimulates the kinin-B2 receptor (B1BKR), providing a novel understanding of the physiological roles of these receptors. PMID: 23735753
    8. the role of bradykinin B2 receptor in vascular endothelium and it's regulation by bradykinin B1 receptor PMID: 23306173
    9. Data suggest that expression of Bdkrb2 is up-regulated in adrenal medulla as the result of stress (here, immobilization stress); data from rats with pharmacological adrenalectomy suggest this up-regulation requires adrenomedullary glucocorticoids. PMID: 24025224
    10. Heightened bradykinin B2 receptor expression in the sensory nerves contributes to the exaggerated muscle mechanoreflex in rats with femoral artery occlusion. PMID: 23417862
    11. Data show the important roles of B1 and B2 bradykinin receptors in overactive urinary bladder syndrome (OAB) following spinal cord injury in rats and suggest that blockade of these receptors could be a therapeutic target for controlling OAB PMID: 22862305
    12. Kinin-B2 receptor activity determines the differentiation fate of neural stem cells. PMID: 23132855
    13. Observations demonstrate a novel role of plasma kallikrein and bradykinin activation in the synovial recruitment of endothelial stem cells in arthritis, acting via kallikrein activation and B2R-dependent mechanisms. PMID: 22739815
    14. Our study suggests that hyperglycemia induces apoptosis via the stimulation of B1R and B2R expression through CB1R activation in rat podocytes in vitro PMID: 22877648
    15. Aging cardiac endothelial cells gradually lose their capacity to express BK-2Rs. PMID: 21986469
    16. In the medulla, chronic exercise could hyperstimulate the kallikrein-kinin system enhancing its efficiency via the increase of bradykinin B2 receptor density, involving this receptor in central cardiovascular control during exercise or stress. PMID: 20637711
    17. expression of KLKI and B2R changed in an age-dependent pattern in the corpus cavernosum and have a tendency to decline during ageing PMID: 20345876
    18. Tanshinone IIA is cardioprotective in the context of diabetic cardiomyopathy through kinin B2 receptor-Akt-GSK-3beta dependent pathway. PMID: 21232147
    19. Data suggest that spinal dynorphin may maintain pancreatitis pain through direct or indirect activation of BK B2 receptors in the spinal cord. PMID: 20531238
    20. The structure of the rat kinin B2 receptor gene (KB2r) and encoding messenger RNA (mRNA) processing, was examined. PMID: 20198577
    21. Although B2BKR expression was not altered in the middle cerebral arteries of spontaneously hypertensive rats after hypertensive encephalopathy or cerebral hemorrhage, bradykinin-mediated relaxation was abolished. PMID: 19954757
    22. in normal rat knee joints, PAR4 activation increases joint primary afferent activity in response to mechanical stimuli. This PAR4-induced sensitization is TRPV1-independent but involves B2 receptor activation, suggesting a role for kinins in this process PMID: 19889854
    23. Data show that bradykinin-induced plasma extravasation is mediated by bradykinin B2 receptors and is inhibited by nociceptin. PMID: 19544046
    24. MEDIATES the formation of vasogenic brain edema in rats PMID: 11686492
    25. Upregulation of kinin B2 receptor mRNA in the hypothalamus of spontaneously hypertensive rats from early age may participate in the pathogenesis of hypertension. PMID: 12025958
    26. Activation of bradykinin 2 receptor negatively modulates the phosphorylation of Erk1 and Erk2 induced by insulin-like growth factor-1, platelet-derived growth factor-BB, and high glucose in the kidney glomerulus. PMID: 12025970
    27. the cell-specific regulation of the BKB2 receptor and the importance of a silencer element present in the regulatory region of the gene. PMID: 12435802
    28. results demonstrated a stage-specific expression of the bradykinin B(2) receptor in different cells of the seminiferous tubules of the rat testis PMID: 12444060
    29. Up-regulation of bradykinin B2-receptor in early stages of cardiac wound healing induced by ischemia and in chronic stages of cardiac remodeling indicates that kinins play a major role in the complex processes of cardiac tissue injury and repair PMID: 12489796
    30. findings suggest that bradykinin B2 receptor is involved in mediating the stimulatory effect of bradykinin on pro-spermatogonial cell proliferation PMID: 12558524
    31. stage-dependent specific expression of tissue kallikrein and bradykinin B2 receptors in developing germ cells and peritubular cells suggests a potential role in the local regulation of spermatogenesis PMID: 12558526
    32. Down-regulation of bradykinin B2-receptor mRNA in the heart in pressure-overload cardiac hypertrophy in the rat. PMID: 12623134
    33. increased bradykinin B(2) receptor expression in the hypothalamus and adrenal glands may play a role in the abnormalities of the hypothalamo-pituitary-adrenal axis during the development of hypertension PMID: 12639805
    34. Effects of angiotensin II on cell differentiation and cyclic GMP production were mediated via the AT2 receptor and further enhanced by bradykinin B2 receptor blockade PMID: 12694402
    35. Kindling-induced epilepsy results in a significant decline of B(2) receptor binding sites in the rat brain. An altered balance between B(1) and B(2) receptor populations may play a pivotal role in the onset and/or maintenance of epilepsy. PMID: 12746865
    36. there are two functionally divergent p53-responsive elements in the rat bradykinin B2 receptor promoter PMID: 12791684
    37. ongoing pressure overload leads to a loss of BK-2Rs with a dramatic increase in left ventricular fibrosis followed by diastolic dysfunction and heart failure. PMID: 12923406
    38. Mediator role of bradykinin in ischemic brain damage including edema formation, obviously by ligand binding to bradykinin B2 receptor. Receptor antagonist may be treatment in stroke patients. PMID: 14753436
    39. Angiotensin II regulates expression of B2KR in vascular smooth muscle cells PMID: 14766673
    40. B2 receptor activation promotes synovial endothelial cell proliferation in acute synovitis. PMID: 14766794
    41. B1R & B2R signaling show physiologic antagonism. B2R antagonism decreased leukocyte & synovial CD44 & CD54 & endothelial CD11b expression, implicating B2R in the acute phase of inflammation by facilitating leukocyte activation, homing, & transmigration. PMID: 15001555
    42. These studies demonstrate that urothelial expression of bradykinin receptors is plastic and is altered by pathology. PMID: 15576455
    43. phospholipase C (PLC)gamma1 can interact with the immunoreceptor tyrosine-based inhibition motif (ITIM) sequence located in the C-terminal part of the bradykinin B2 receptor; interaction was only observed in quiescent and not in proliferating cells PMID: 15607753
    44. Age-related decreases in bradykinin B2 receptor may leave heart vulnerable to ischemic damage, and increases in bradykinin B1 receptor may represent compensatory reaction in aging hearts. PMID: 15708952
    45. In conclusion, the findings from this study indicate that exercise training alters the localization of FAT/CD36 and increases its association with CPT I, which may help augment fat oxidation. PMID: 16507603
    46. after hepatic ischemia, angiotensin-converting enzyme (ACE) inhibition reduced reperfusion injury in a bradykinin-2-receptor-dependent manner PMID: 16513137
    47. We report the distance between the AT2R and B2R in PC12W cell membranes to be 50+/-5 A, providing evidence and quantification of receptor heterodimerization as the mechanism for enhancing NO production PMID: 16754789
    48. Implication of both kinin B1 and B2 receptors in thermal hyperalgesia but not in tactile and cold allodynia associated with peripheral nerve injury. PMID: 18182225
    49. Results show that plasma membrane and highly purified nuclei from isolated rat hepatocytes contain specific bradykinin B2 receptors that bind bradykinin. PMID: 18264983
    50. kinin-B2 receptors and BK secretion indicate an autocrine loop during neurosphere differentiation to neurons, astrocytes, and oligodendrocytes, reflecting events occurring during early brain development PMID: 18302192

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  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family, Bradykinin receptor subfamily, BDKRB2 sub-subfamily
  • 組織特異性：
    Uterus, vas deferens, kidney, ileum, heart, testis, lung and brain.
  • 數(shù)據(jù)庫鏈接：