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Recombinant Pig Sterol regulatory element-binding protein 1 (SREBF1)

  • 中文名稱：
    斯克羅法SREBF1重組蛋白
  • 貨號：
    CSB-CF022657PI
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    SREBF1; ADD1; SREBP1; Sterol regulatory element-binding protein 1; SREBP-1; Adipocyte determination and differentiation-dependent factor 1; Sterol regulatory element-binding transcription factor 1
  • 種屬：
    Sus scrofa (Pig)
  • 蛋白長度：
    Full length protein
  • 表達區(qū)域：
    1-490
  • 氨基酸序列
    MDEPPFTEAALEQALAEPCELDAALLTDIEDMLQLINNQDSDFPGLFDAPYAGVAGGTDP TSPDASSPGSPTPPPSTMSSPLEGFLGGARTPPPPPVSPTQPAPTPLKMYPSVPAFSPGP GIKEEPVPLTILQPPTPQPLSGALLPQSLPALAPPQLSPAPVLGYPSPPGSFSSATPPGS TSQTLPGLPLASLPGVLPVSVHTQVQSAAPQQLLTATATPVVSPGTTTVTSQIQQVPVLL QPHFIKADSLLLTTMKTDMGTPVKAAGIGSLAPGTAVQAAPLQTLVSGGTILATVPLVVD TDKLPINRLAAGGKALSSGQSRGEKRTAHNAIEKRYRSSINDKIIELKDLVVGTEAKLNK SAVLRKAIDYIRFLQQSNQKLKQENLSLRTAAHKSKSLKDLVSCSSGGRTDVPMEGVKPE VVDTLSPPPSDAGSPSQSSPLSLGSRGSSSGGSGSDSEPDSPVFEDSQMKPEQLPAPHGR GMLDRSRLAL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane. Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis.; Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation.
  • 基因功能參考文獻：
    1. In vivo, the data of established transgenic animals showed that mice with lncHR1 expression had less hepatic expression of SREBP-1c, FAS, Acetyl-CoA carboxylase alpha (ACCalpha), and less hepatic and plasma TG after being fed a high-fat diet. PMID: 28367099
    2. Polymorphisms of the ACACA and SREBF1 genes are promising markers for pig carcass and performance traits. PMID: 23657179
    3. Results of associated analysis show that the polymorphism of ADD1 gene was associated traits of Intramuscular fat content (IMF) and back fat thickness (BF). PMID: 16520310
    4. SREBF1 might play an important role in regulation of muscle fat deposition during postnatal growth of pigs. PMID: 17878274
  • 亞細胞定位：
    [Sterol regulatory element-binding protein 1]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein.; [Processed sterol regulatory element-binding protein 1]: Nucleus.
  • 蛋白家族：
    SREBP family
  • 數(shù)據(jù)庫鏈接：

    KEGG: ssc:397308

    UniGene: Ssc.15992