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  4. Recombinant Mouse Interleukin-1 receptor type 1 (Il1r1)

Recombinant Mouse Interleukin-1 receptor type 1 (Il1r1)

  • 中文名稱：
    小鼠Il1r1重組蛋白
  • 貨號(hào)：
    CSB-CF011621MO
  • 規(guī)格：
  • 來(lái)源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
    Il1r1
  • Uniprot No.：
  • 別名：
    Il1r1; Il-1r1; Il1ra; Interleukin-1 receptor type 1; IL-1R-1; IL-1RT-1; IL-1RT1; CD121 antigen-like family member A; Interleukin-1 receptor alpha; IL-1R-alpha; Interleukin-1 receptor type I; p80; CD antigen CD121a
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Full Length of Mature Protein
  • 表達(dá)區(qū)域：
    20-576
  • 氨基酸序列
    LEIDVCTEYPNQIVLFLSVNEIDIRKCPLTPNKMHGDTIIWYKNDSKTPISADRDSRIHQQNEHLWFVPAKVEDSGYYYCIVRNSTYCLKTKVTVTVLENDPGLCYSTQATFPQRLHIAGDGSLVCPYVSYFKDENNELPEVQWYKNCKPLLLDNVSFFGVKDKLLVRNVAEEHRGDYICRMSYTFRGKQYPVTRVIQFITIDENKRDRPVILSPRNETIEADPGSMIQLICNVTGQFSDLVYWKWNGSEIEWNDPFLAEDYQFVEHPSTKRKYTLITTLNISEVKSQFYRYPFICVVKNTNIFESAHVQLIYPVPDFKNYLIGGFIILTATIVCCVCIYKVFKVDIVLWYRDSCSGFLPSKASDGKTYDAYILYPKTLGEGSFSDLDTFVFKLLPEVLEGQFGYKLFIYGRDDYVGEDTIEVTNENVKKSRRLIIILVRDMGGFSWLGQSSEEQIAIYNALIQEGIKIVLLELEKIQDYEKMPDSIQFIKQKHGVICWSGDFQERPQSAKTRFWKNLRYQMPAQRRSPLSKHRLLTLDPVRDTKEKLPAATHLPLG
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells.; Unable to mediate canonical IL-1 signaling. Cooperates with IL1RAP isoform 3 to mediate IL1B-induced neuronal activity including IL1B-potentiated NMDA-induced calcium influx mediated by Akt kinase activation.
  • 基因功能參考文獻(xiàn)：
    1. Study conclude that while interleukin-1 signaling is not critical for lipopolysaccharide induced anorexia or stress hormone release, interleukin-1 type 1 receptor expressed on brain endothelial cells, contributes to the febrile response to lipopolysaccharide. PMID: 28655587
    2. Data indicate that IL-1RI and TNF-1R contribute to regulation of stress-induced, negatively reinforced drinking perhaps through overlapping signaling events downstream of these receptors, while leaving rewarding properties of alcohol largely unaffected. PMID: 27273552
    3. interleukin-1 receptor 1/MyD88 signalling has roles in the development and progression of pulmonary hypertension PMID: 27418552
    4. These results suggest that cytokines, particularly IL-1, areassociated with pulmonary anti-influenza immune response and inflammatory lung injury, particularly via the influence on neutrophil mobilization and inflammatory cytokine/chemokine production. PMID: 28585438
    5. Using respective knockout mice it was found that LPS-mediated GIP secretion was selectively dependent on IL-1 signalling. PMID: 27350651
    6. Results demonstrated the essential role of IL-1R1 in kindling-induced sleep disturbance by using transgenic IL-1R1 KO mice. Epilepsy-induced sleep disturbances were absent in the IL-1R1 KO mice, indicating the importance of IL-1 signals. The knockout of IL-1R1 did not change the seizure thresholds, suggesting that IL-1R1 signaling is not in involved in the kindling-induced epileptogenesis. PMID: 27875989
    7. findings show elements of the IL-1 network, including IL-1alpha, IL-1beta, and IL-1R1, are essential for the optimal host response to VACV cutaneous infection PMID: 28468973
    8. These data show that the normal distribution of surface glycosylation requires IL-1R, but not MyD88, and is not sufficient to prevent bacterial binding. PMID: 28223334
    9. Study provides direct evidence that IL-1R1 is a potent target for adjunctive control of diazepam refractory status epilepticus in mice. Both pharmacological block and gene KO of IL-1R1 may reverse or prevent the progressive diazepam-refractoriness of status epilepticus in mice. Thus, combination of IL-1R1 antagonists with diazepam may be a novel strategy for the treatment of refractory prolonged status epilepticus. PMID: 27133574
    10. IL-1R1 signaling via MyD88 is critical for the first step of inflammatory response to papain. PMID: 27569535
    11. IL-1 receptor (IL-1R1) deficiency or blockade limits blood pressure elevation in this model by mitigating sodium reabsorption via the NKCC2 co-transporter in the nephron. PMID: 26712462
    12. mediates signals by allograft parenchymal cells in generating the stimuli-provoking development and elicitation of optimal alloimmune responses to the grafts PMID: 26856697
    13. data identify a previously unappreciated Trim24-dependent requirement for IL-1R expression on TH2 cells and an important nonredundant role for T-cell-intrinsic Trim24 in TH2-mediated allergy and antihelminth immunity PMID: 26787865
    14. The results present identification of critical regions within the TIR domain of IL-1 receptor type in humans and mice. PMID: 26279140
    15. IL-1R1/MyD88 signaling negatively regulates bone regeneration via impairment of mesenchymal stem cell proliferation, migration and differentiation by inhibiting the Akt/GSK-3beta/beta-catenin pathway. PMID: 27001940
    16. adult mice lacking interleukin-1 receptor 1 (IL-1R1) exhibit increased expression of both the excitatory scaffolding protein postsynaptic density-95 (PSD-95) and inhibitory scaffolding proteingephyrin, respectively, in the hippocampus. PMID: 25263489
    17. these studies demonstrate, through the use of novel transgenic mice, that IL1R1 on neurons and astrocytes differentially mediates aspects of sleep PMID: 25849975
    18. Results suggest that the IL-1R1/IL-1ra complex regulates specific ethanol behaviors and affects the sensitivity to flurazepam sedation PMID: 25839897
    19. IL-1R1 contributes to the IMQ-induced skin inflammation, and disruption of MyD88 signaling completely abrogates this response. PMID: 26147228
    20. Data show that interleukin 1beta (IL-1beta) increased the expression of the IL-1 receptor type 1 in hippocampal neuronal cultures. PMID: 26305968
    21. Because IL-1R-/- mice have impaired bystander responses during in vivo infection, we investigated whether IL-1R signaling was sufficient to induce TNF, IL-6, or CD86 expression in various innate immune cell types. PMID: 26034289
    22. These results demonstrate this IL-1R1 restore model is a valuable tool for studying cell-type-specific functions of IL-1R1. PMID: 25698726
    23. the NLRP3 inflammasome/IL-1RI axis is dispensable for PM10-facilitated allergic sensitization. PMID: 24988285
    24. Contrary to prior studies, IL-1RI(-/-) mice are not robustly impaired on hippocampal-dependent memory. PMID: 24205219
    25. major population of intestinal lamina propria lymphocytes expressing IL-1 receptor 1 (IL-1R1) is the lymphoid tissue inducer (LTi)-like cell PMID: 23750260
    26. Overexpression of Sprouty4 or pharmacological inhibition of ERK upregulated IL-1R1 expression in primary T cells. PMID: 24732356
    27. The role of IL-1 receptor and toll-like receptor 2 in the induction of MyD88-dependent immunization with a Coccidioides vaccine are reported. PMID: 24614655
    28. These results demonstrate a role for the NLRP3 inflammasome in the control of Trypanosoma cruzi infection and identify NLRP3-mediated, caspase-1-dependent and IL-1R-independent nitric oxide production as a novel effector mechanism. PMID: 24098823
    29. Both wild-type (WT) and eIL-1R1kd mice had increased circulating monocytes PMID: 24523548
    30. IL-1 signaling, via IL-1R1 and MyD88, is required for development of postoperative ileus after intestinal manipulation in mice. PMID: 24067878
    31. early stimulation of fibroblast IL-1R1 signaling during the inflammatory phase may prevent premature activation of a matrix-synthetic contractile phenotype until the wound is cleared, and the infarct microenvironment can support mesenchymal cell growth. PMID: 24078695
    32. Knockout of IL-1RI protected mice from high fat diet-induced adipose tissue inflammation and insulin resistance. PMID: 22841542
    33. These findings indicate an important interaction between dietary fat and IL-1R, relevant to optimal metabolic health. PMID: 23921145
    34. These results suggest that IL-1RI is involved in normal growth plate development and extracellular matrix homeostasis and that it is significant in the physiological process of bone modeling. PMID: 23592480
    35. These results demonstrate that IL-1alpha and IL-1R1 signaling is essential for microabscess formation, neutrophil recruiting chemokine expression, and acanthosis in psoriasis-like skin inflammation induced by imiquimod. PMID: 23407395
    36. High viral persistence is found in the late stage of Theiler's virus infection in IL-1R-deficient mice. PMID: 22985464
    37. Functional IL-1 receptor is required for Th17, but not Th2, cytokine production after in vitro antigen restimulation of lung cells. PMID: 23371061
    38. data indicate that IL-1R1 signaling promotes virologic control during West Nile virus infection specifically within the central nervous system PMID: 23460727
    39. study found that after infection with live influenza A virus, signaling through the interleukin 1 receptor was required for productive priming of CD8( ) T cells, but signaling through the pattern-recognition receptors TLR7 and RIG-I was not PMID: 23314004
    40. IL-1RI signalling is a major antimicrobial effector pathway during acute brain-abscess formation. PMID: 22414156
    41. Doxorubicin toxicity increased IL-1RI expression in cardiac tissues. Expression correlated with histology score in cardiotoxic injury. PMID: 22000485
    42. Lymphocytic choriomeningitis virus is not cleared in IL-1R-deficient mice, and yet the infected mice develop neither splenomegaly nor hepatitis. PMID: 22674984
    43. IL1R activation contributes to hypersomnolence that occurs after sleep loss PMID: 22387068
    44. The immune pathogenesis of IL-1/IL-1R1 signaling on the ocular surface and in the lacrimal gland depends on tissue-specific CD4+ T cells and activation of IL-1R1-expressing epithelial and stromal cells. PMID: 22231738
    45. These results indicate that IL-1R signaling is required at multiple steps during the course of sensitization and challenge to elicit Contact hypersensitivity. PMID: 22238457
    46. TIR8 has a nonredundant effect in modulating the inflammation caused by Pseudomonas aeruginosa, in particular, by negatively regulating IL-1RI signaling, which plays a major role in the pathogenesis of bacterial pneumonia. PMID: 22025515
    47. Inhibition of MyD88- or IL-1 receptor signalling reduces neointima formation in response to carotid artery injury. PMID: 21421554
    48. The response in aged IL-1R knockout mice differs from wild-type mice in that starvation increases atrophy and is associated with decreased cell proliferation rather than increased apoptosis. PMID: 20605606
    49. Lack of IL-1RI protects against HFD-induced IR coincident with reduced local adipose tissue inflammation, despite equivalent immune cell recruitment. PMID: 21515850
    50. Following exposure to cigarette smoke in IL-1RI-deficient mice, PTX3 expression is not enhanced compared to wild-type mice. PMID: 20920344

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein. Cell membrane. Secreted.
  • 蛋白家族：
    Interleukin-1 receptor family
  • 組織特異性：
    Isoform 2 is expressed in various brain tissues.
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: mmu:16177

    STRING: 10090.ENSMUSP00000027241

    UniGene: Mm.896