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  4. Recombinant Mouse Toll-like receptor 9 (Tlr9), partial

Recombinant Mouse Toll-like receptor 9 (Tlr9), partial

  • 中文名稱：
    小鼠Tlr9重組蛋白
  • 貨號：
    CSB-YP023608MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Tlr9重組蛋白
  • 貨號：
    CSB-EP023608MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Tlr9重組蛋白
  • 貨號：
    CSB-EP023608MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Tlr9重組蛋白
  • 貨號：
    CSB-BP023608MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Tlr9重組蛋白
  • 貨號：
    CSB-MP023608MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Tlr9
  • Uniprot No.：
  • 別名：
    Tlr9; Toll-like receptor 9; CD antigen CD289
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Plays a role in defense against systemic mouse cytomegalovirus infection. Controls lymphocyte response to Helicobacter infection. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production.
  • 基因功能參考文獻：
    1. Microglial glucocorticoid receptors regulate TLR9 trafficking and lysosomal environment. Loss of glucocorticoid receptors enables activation of a microglial TLR9 inflammatory pathway, which can play a role in the progression of Parksinson disease. PMID: 29934589
    2. TLR9 activation is augmented by short single-stranded DNA degradation products PMID: 28530246
    3. Study shows that placental and/or fetal DNA stimulates toll-like receptor 9 (TLR9) leading to secretion of pro-inflammatory cytokines by macrophage cells. PMID: 28884630
    4. Plasmodium DNA induces autoreactive responses against erythrocytes by activating a population of B cells expressing CD11c and the transcription factor T-bet, which become major producers of autoantibodies that promote malarial anaemia. PMID: 29101363
    5. Our findings suggested the collaboration of TLR2-TLR9 at least in the regulation of SARM expression. PMID: 28889202
    6. High cholesterol intake exacerbated acetaminophen-induced acute liver injury via the accumulation of free cholesterol in the endolysosomes of liver sinusoidal endothelial cells. This accumulation enhanced Toll-like receptor 9 signaling via impairment of its membrane trafficking mechanism. PMID: 28554874
    7. these data provide a previously uncharacterized in vivo mechanism contingent on oligodeoxy-nucleotide -administered dose, where TLR9 governs the primary response and RAGE plays a distinct and cooperative function in providing a pivotal role in balancing the immune response. PMID: 28605247
    8. this study shows that CD205-TLR9-IL-12 axis contributes to CpG-induced oversensitive liver injury in Hepatitis B viral antigens transgenic mice by promoting the interaction of NKT cells with Kupffer cells PMID: 27041637
    9. The findings support a salutary role of TLR9 in some subsets of HF conditions and underline the importance for future studies on the mechanisms of TLR9 in diastolic HF. PMID: 28490840
    10. TLR9-driven inflammation induced a Ccr2-independent expansion of functionally enhanced extramedullary myeloid progenitors that correlated with the peripheral accumulation of monocytes in both wild-type and Ccr2(-/-) mice. PMID: 27621476
    11. TLR9 expression on B1a cells is not critical for their IgM-dependent atheroprotection. PMID: 27930350
    12. This study establishes a correlation between TLR-3 and TLR-9 expression with the development of EAE. In addition, evidence of a role for the myelin peptide in targeting the innate inflammatory response to the CNS is presented. PMID: 26911613
    13. these data demonstrate that TLR7/TLR9 ligands push the macrophage into a phagocytic long-lived cell, with a decreased capacity of antigen presentation and reminiscent of the M2 polarized state. PMID: 26567289
    14. TLR9/MyD88 signaling selectively in CD11c(+) dendritic cells (DCs) strongly enhances murine cytomegalovirus clearance. PMID: 27760315
    15. Overall, the data reveal that the early recruited sTLR9(+) neutrophils may, at least in the area of local inflammation, play a protective role during SIRS development and provide a method to rescue the patients with severe SIRS via the up-regulation of sTLR9 levels on the surface of neutrophils or via adoptive therapy with protective sub-populations of neutrophils. PMID: 28704709
    16. High-glucose induces tau hyperphosphorylation through activation of TLR9-P38 MAPK pathway. PMID: 28803064
    17. proposed that TLR9 regulates the NF-kappaB-NLRP3-IL-1beta pathway negatively in Salmonella-induced NKG2D-mediated intestinal inflammation and plays a critical role in defense against S. typhimurium infection and in the protection of intestinal integrity. PMID: 28576980
    18. mechanism integrating BCR, TLR9, and cytokine signals provides a peripheral checkpoint for DNA-containing antigens that, if circumvented by survival and differentiative cues, yields B cells with the autoimmune-associated T-bet+ phenotype. PMID: 28346226
    19. we demonstrated for the first time that the cross-talk of TLR2 and TLR9 triggered Th1 activation collaboratively PMID: 27693915
    20. the cooperative role of TLR9 with TLR2 or TLR6 receptors in sensing Brucella, was determined. PMID: 26578650
    21. accelerating effects of Tlr9 deficiency PMID: 28278279
    22. Increased circulating mtDNA combined with upregulated TLR9 expression may corporately play a role in EAM as well as TLR4 activation mediated cardiac inflammation and injury PMID: 28618428
    23. Data show that inoculating mice deficient in toll-like receptors TLR4 or TLR9 with LPS or CpG-stimulated eosinophils, NK cell recruitment was observed alongside cytotoxicity. PMID: 28426135
    24. Significantly lower levels of interferon-stimulated gene expression in response to purified curli-DNA in TLR2 and TLR9 deficient mice compared to wild-type mice. PMID: 28410407
    25. these data provide a new perspective on the complexity of TLR9 regulation by proteolytic cleavage PMID: 27421483
    26. platelet response to S. pneumoniae and a role for TLRs, is reported. PMID: 27253707
    27. Mechanical ventilation does not result in the release of mtDNA, and TLR9 is not involved in mechanical ventilation-induced inflammation PMID: 28099322
    28. this study shows that human beta-defensin 3 amplifies the response to bacterial DNA in immune cells in a TLR9-dependent manner PMID: 28102569
    29. The mRNA expression of TLR4 and NF-kappaB is decreased in a neonatal murine model of necrotizing enterocolitis. PMID: 27357505
    30. Although the TLR9 signaling pathway is not involved in the acute inflammatory response in infarct hearts, it ameliorates cardiac rupture possibly by promoting proliferation and differentiation of cardiac fibroblasts. PMID: 27769998
    31. loss of Tlr9 selectively augments the intensity of IL-17-driven immune responses to H. pylori in a cag T4SS-dependent manner. PMID: 27758771
    32. functional Tlr9 signaling in neutrophils, is an important mechanism in early stasis experimental venous thrombogenesis. PMID: 26482993
    33. this paper shows that endosomal retention of TLR9 via the interaction of IRAP with the actin cytoskeleton is a mechanism that prevents hyper-activation of TLR9 in dendritic cells PMID: 28319098
    34. data demonstrated for the first time that NK cells directly recognize Baculovirus via TLR9, which provides opportunities for the use of this technique as an effective tool for Baculovirus-based immunotherapies against malignancies. PMID: 28186087
    35. 3-Hydroxy-4,7-megastigmadien-9-one, isolated from Ulva pertusa, attenuates TLR9-mediated inflammatory response by down-regulating mitogen-activated protein kinase and NF-kappaB pathways. PMID: 27937044
    36. Results demonstrate that nerve stimulation of TLR9 knock-out muscles produces weaker response than when the muscle is stimulated directly; TLR9 knock-out mice have functional and morphological alterations of the neuromuscular junction PMID: 26955780
    37. Munc13-4 regulates endosome-initiated, TLR9-dependent signaling and TLR9-specific cellular functions in neutrophils. PMID: 26680738
    38. TLR9 expression showed dynamic changes for a long period of time and microglias were the main brain cells to express TLR9 after cerebral ischemia and reperfusion. PMID: 26000727
    39. These findings demonstrate differential reaction of cholinesterase-targeting miRNAs to distinct TLR9 challenges, indicating upstream miRNA co-regulation of the intestinal alternative NFkappaB pathway and cholinergic signaling. PMID: 26003847
    40. critical for late venous thrombosis resolution; associated with necrosis clearance, but does not affect vein wall fibrosis PMID: 26179893
    41. activated ARF3 is associated with Unc93B1 and TLR9, suggesting that ARF3 conducts TLR9 trafficking by forming the TLR9-Unc93B1-ARF3 complex. PMID: 26067373
    42. In mice, nonalcoholic steatohepatitis development in response to a high-fat diet required TLR9 on lysozyme-expressing cells PMID: 26808498
    43. TLR9 activation at high and low CpG ODN concentrations has roles in acute and chronic vascular injury in mice PMID: 26751387
    44. The current study demonstrates for the first time an immunomodulatory role for TLR9 in acute kidney injury by enhancing the capacity of Tregs to migrate to damaged tissue in a model of common and relevant kidney disease. PMID: 26116356
    45. recognition of beta-1,3 glucan by Dectin-1 triggers TLR9 trafficking to beta-1,3 glucan-containing phagosomes, which may be critical in coordinating innate antifungal defense. PMID: 26829985
    46. protein deficiency protects female lupus-prone lupus like disease PMID: 26553076
    47. Sustained activation of Toll-like receptor 9 causes cardiac and systemic inflammation, and deterioration of SERCA2a depletion-mediated diastolic heart failure. PMID: 26461521
    48. TLR9 signaling is involved in regulating adipose tissue inflammation and controlling obesity and the metabolic syndrome. PMID: 26260403
    49. Genetic deletion of MyD88, TLR2 or TLR9 effectively controlled the signs of intestinal injury when compared with irinotecan-administered WT controls PMID: 26440613
    50. AP-3 recruitment to TLR9 endosomes was impaired by PIKfyve inhibition. PMID: 25925170

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  • 亞細胞定位：
    Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome.
  • 蛋白家族：
    Toll-like receptor family
  • 組織特異性：
    Expressed in the basolateral region of gastric epithelial cells with high levels detected in antrum and body mucosa (at protein level). Detected in spleen and stomach at higher levels in C57BL/6 mice than BALB/C.
  • 數(shù)據(jù)庫鏈接：