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Recombinant Mouse Interleukin-5 (Il5)

  • 中文名稱：
    小鼠Il5重組蛋白
  • 貨號：
    CSB-YP011662MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Il5重組蛋白
  • 貨號：
    CSB-EP011662MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Il5重組蛋白
  • 貨號：
    CSB-EP011662MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Il5重組蛋白
  • 貨號：
    CSB-BP011662MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Il5重組蛋白
  • 貨號：
    CSB-MP011662MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Il5
  • Uniprot No.：
  • 別名：
    Il5; Il-5Interleukin-5; IL-5; B-cell growth factor II; BCGF-II; Cytotoxic T-lymphocyte inducer; Eosinophil differentiation factor; T-cell replacing factor; TRF
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達(dá)區(qū)域：
    21-133
  • 氨基酸序列
    MEIPMSTVVK ETLTQLSAHR ALLTSNETMR LPVPTHKNHQ LCIGEIFQGL DILKNQTVRG GTVEMLFQNL SLIKKYIDRQ KEKCGEERRR TRQFLDYLQE FLGVMSTEWA MEG
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.
  • 基因功能參考文獻(xiàn)：
    1. binding of IL-5 to IL-5Ralpha receptors enhances angiogenic responses by stimulating the expression of HSP70-1 via the eNOS signaling pathway. PMID: 28317868
    2. IL-33 acts directly on bone marrow ILC2s, making them an early source of IL-5 and part of a process that is central in IL-33-driven eosinophilia. PMID: 28921511
    3. Obesity alters the lung neutrophil infiltration to enhance breast cancer metastasis through IL5 and GM-CSF. PMID: 28737771
    4. these studies establish a basal defect in eosinophilopoiesis in IL-33- and ST2-deficient mice and a mechanism whereby IL-33 supports eosinophils by driving both systemic IL-5 production and the expansion of IL-5Ralpha-expressing precursor cells PMID: 27683753
    5. Increased production of IL-5 from Peyer's patch cells and the restored Th1-type immune response might cause the production of abnormal IgA and might induce the glomerular deposition of IgA in IGA nephropathy. PMID: 26719095
    6. selective proliferation of IgM rheumatoid factor-secreting B-1a cells is induced by co-stimulation by the specific pathogen antigen and IL-5 in the development of MC in Capillaria hepatica-infected mice PMID: 25452118
    7. IL5, a cytokine involved in allergic and infectious diseases, facilitates metastatic colonization through recruitment of sentinel eosinophils and regulation of other inflammatory/immune cells in the microenvironment of the distal lung. PMID: 25691457
    8. Data (including data from knockout mice) suggest that up-regulation of IL5 production in lungs during influenza virus infection is due to infiltration of natural killer cells and alveolar macrophages into infected lung tissue. PMID: 24068930
    9. A decrease in the levels of IL-5, IL-9, and IL-6R in the BALF. PMID: 24246030
    10. eosinophils express CAR4 following IL-5 or allergen exposure, and that CAR4 is involved in regulating the lung transcriptome associated with allergic airway inflammation PMID: 24808371
    11. Protection of montelukast on OVA-induced eosinophilic gastroenteritis via modulating IL-5, eotaxin-1 and MBP expression. PMID: 23855447
    12. Together, these studies support the conclusion that surfactant protein D increases susceptibility to Cryptococcus neoformans infection by promoting Cryptococcus neoformans-driven pulmonary IL-5 and eosinophil infiltration. PMID: 24478083
    13. IL5 induced eosinophils and cysteinyl leukotrienes are involved in the pathology of mite antigen-induced chronic asthma model. PMID: 23942524
    14. Id3 is a key regulator of natural helper cell IL-5 production and B-1a B cell homeostasis. PMID: 24115031
    15. Interleukin-5 plays a key role in mouse strain- dependent susceptibility to contact hypersensitivity through its effects on initiator B cells. PMID: 23711860
    16. macrophage IL-5 is a target gene for LXR activation, and the induction of macrophage IL-5 expression can be related to LXR-inhibited atherosclerosis. PMID: 23150660
    17. Ang II induces increased Th2 cytokines IL-5 and IL-10 early in the course of experimental abdominal aortic aneurysm formation, and inhibition of IL-5 prevents AAA formation suggesting an important role. PMID: 22459292
    18. Sex difference in IL-5 production by splenocytes might be due, at least in part, to the sex difference in the sensitivity of CD4+ T cells to suppression by CD8+ T cells. PMID: 22627364
    19. Invading tumor cells enhance and increase local IL-5 production from innate IL-5-producing non-T lymphoid cells residing in the intestine, peritoneal cavity and lungs of naive mice. PMID: 22174445
    20. PARP-1 regulates Il-5 production through calpain degradation of STAT-6 in a murine asthma model. PMID: 21276008
    21. IL-5 production by splenocytes triggered by TCR activation was higher in female mice than in male mice, and the difference might be attributable to sex differences in CD4+ and CD8+ T cell functions. PMID: 21646791
    22. Transnasal administration of liposome- mediated IL12 could depress the expression of IL-5 in bone marrow, peripheral blood, and nasal mucosa in allergic rhinitis. PMID: 19954023
    23. Exacerbation of oxazolone colitis by infection with the helminth Hymenolepis diminuta: involvement of IL-5 and eosinophils. PMID: 21037078
    24. Greater antigen-induced Th2 IL-5 production by bronchial lymph node cells from female mice was associated with enhanced Th2 cell differentiation and increased expression of the Th2-specific transcription factor, GATA-3. PMID: 20337994
    25. IL-5 production by bronchial epithelial cells can impact the microenvironment of the lung, modifying pathologic and protective immune responses in the airways PMID: 20494340
    26. IL-5 promotes eosinophil trafficking to the esophagus PMID: 11859139
    27. IL-5 is required for the development of tissue and marrow eosinophilia, the formation of eosinophil/basophil colony-forming units, and the early development of symptoms in experimental allergic rhinitis. PMID: 11884474
    28. Role of IL-5 during primary and secondary immune response to acetylcholine receptor. PMID: 11960640
    29. mechanism of synergism between eotaxin and IL5, facilitating the selective recruitment of eosinophils into sites of allergic inflammation PMID: 12083417
    30. A putative Bcl6-binding DNA sequence which acts as a silencer element has been identified in the 3' untranslated region of IL-5 cDNA. PMID: 12097386
    31. IL-5 alone does not account for the complexities of bronchopulmonary hyperreactivity or of eosinophil tissue trapping PMID: 12231478
    32. effects of constitutive interleukin-5 (IL-5) expression and overabundance of eosinophils on the development and function of the mammary gland, uterus, and ovary PMID: 12620930
    33. IL-5 appears to be required for the accumulation of eosinophils and airway hyperresponsiveness in the inflammatory lung. PMID: 12660425
    34. The ability of IL-13 to induce eosinophilic esophagitis was abolished in STAT6-deficient mice, nearly completely ablated in IL-5-deficient mice, and significantly diminished in eotaxin-1-deficient mice. PMID: 14598258
    35. immune effector mechanisms in murine filarial infection are dependent on both IFN-gamma and IL-5, whose synergistic effects may be mediated, at least in part, by neutrophils for the control of adult worms. PMID: 14638787
    36. These results suggest an important role for interleukin-5, eosinophils, alphaVbeta6 integrin, and TGF-beta in airway remodeling. PMID: 14966564
    37. Pulmonary fibrosis lesions are abolished in sensitized and allergen-exposed IL-5 receptor-null mice, whereas they are markedly accentuated in IL-5 transgenic animals. PMID: 14975941
    38. Marked impairment of the maintenance of mature B-1 lymphocyte survival and homeostatic proliferation is demonstrated by blocking IL-5 signals. The key question is to what extent IL-5 is involved in mature B-1 cell survival and homeostatic proliferation. PMID: 15128785
    39. IL-5 participates in the pathogenesis of ileitis in SAMP1/Yit mice. PMID: 15162425
    40. CD4(-)c-kit(-)CD3epsilon(-)IL-2Ralpha(+) Peyer's patch cells are capable of secreting a high level of IL-5 in response to IL-2 PMID: 15214040
    41. IL-5 links adaptive and natural immunity for epitopes of oxidized LHDL and protects from arteriosclerosis. PMID: 15286809
    42. Anti-IL-5 was able to reduce eosinophil numbers in all tissue compartments, as well as BrdU+ eosinophils and CD34+ progenitor cells, and in all instances to a greater extent than anti-IL-9. PMID: 15823208
    43. the increase in airway eosinophilia seen with COX inhibition is dependent on IL-5, whereas the increase in airway hyperresponsiveness is not PMID: 16339565
    44. IL-5 is not necessary for differential splicing to occur in vivo, as all three forms of the IL-5R alpha are detected in both strains of IL-5 gene-deleted mice PMID: 16856933
    45. It was found that MCA-induced tumor incidence and growth were significantly attenuated in IL-5 transgenic mice. PMID: 17371978
    46. Il-5 level peaked at 7 dpi in bronchoalveolar lavage fluid. PMID: 17487773
    47. IL-5 gene delivery suppresses sensitization to antigen (ovalbumin) by upregulating transforming growth factor beta 1-dependent signaling to CD4-expressing T cells, thus suppressing allergic airway inflammation. PMID: 17579048
    48. cyclic AMP signals enhance histone H3 acetylation at the IL-5 promoter and the concerted binding of GATA-3 and NFATc to the promoter. PMID: 18772129
    49. there is a reciprocal relationship between inducible nitric oxide synthase and poly(ADP-ribose) polymerase-1; expression of inducible nitric oxide synthase may be dispensable for eosinophilia after interleukin-5 production PMID: 18829681
    50. Healing was significantly delayed in IL-5-overexpressing mice with wounds gaping wider and exhibiting impaired re-epithelialization PMID: 18839016

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    IL-5 family
  • 數(shù)據(jù)庫鏈接：