Recombinant Mouse Growth arrest-specific protein 6 (Gas6)
-
中文名稱:小鼠Gas6重組蛋白
-
貨號:CSB-MP723418MO
-
規(guī)格:¥1908
-
圖片:
-
其他:
產(chǎn)品詳情
-
純度:Greater than 95% as determined by SDS-PAGE.
-
生物活性:Not Test
-
基因名:Gas6
-
Uniprot No.:
-
別名:GAS-6;AXL receptor tyrosine kinase ligand
-
種屬:Mus musculus (Mouse)
-
蛋白長度:Full Length of Mature Protein
-
來源:Mammalian cell
-
分子量:73.4 kDa
-
表達區(qū)域:28-674aa
-
氨基酸序列VLLRAREAAQFLRPRQRRAYQVFEEAKQGHLERECVEEVCSKEEAREVFENDPETEYFYPRYQECMRKYGRPEEKNPDFAKCVQNLPDQCTPNPCDKKGTHICQDLMGNFFCVCTDGWGGRLCDKDVNECVQKNGGCSQVCHNKPGSFQCACHSGFSLASDGQTCQDIDECTDSDTCGDARCKNLPGSYSCLCDEGYTYSSKEKTCQDVDECQQDRCEQTCVNSPGSYTCHCDGRGGLKLSPDMDTCEDILPCVPFSMAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLLAEFDFRTFDPEGVLFFAGGRSDSTWIVLGLRAGRLELQLRYNGVGRITSSGPTINHGMWQTISVEELERNLVIKVNKDAVMKIAVAGELFQLERGLYHLNLTVGGIPFKESELVQPINPRLDGCMRSWNWLNGEDSAIQETVKANTKMQCFSVTERGSFFPGNGFATYRLNYTRTSLDVGTETTWEVKVVARIRPATDTGVLLALVGDDDVVPISVALVDYHSTKKLKKQLVVLAVEDVALALMEIKVCDSQEHTVTVSLREGEATLEVDGTKGQSEVSTAQLQERLDTLKTHLQGSVHTYVGGLPEVSVISAPVTAFYRGCMTLEVNGKILDLDTASYKHSDITSHSCPPVEHATP
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request. -
蛋白標簽:C-terminal 10xHis-tagged
-
產(chǎn)品提供形式:Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
緩沖液:If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
-
復溶:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
-
儲存條件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
-
保質(zhì)期:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期:Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
注意事項:Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
-
Datasheet & COA:Please contact us to get it.
相關(guān)產(chǎn)品
靶點詳情
-
功能:Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.
-
基因功能參考文獻:
- Disinhibiation of Gas6 binding to Tyro3 due to PGRN reduction results in activation of PKCalpha via PLCgamma, inducing tau phosphorylation at Ser203, mislocalization of tau to dendritic spines, and spine loss. PMID: 29382817
- Here, the mechanism by which norepinephrine (NE)regulates prostate cancer DTCs in the marrow is explored. NE directly stimulated prostate cancer cell proliferation through beta2-adrenergic receptors (ADRB2).. NE also altered prostate cancer proliferation in the marrow niche by indirectly downregulating the secretion of the dormancy inducing molecule growth arrest specific-6 (GAS6) expressed by osteoblasts. PMID: 28814453
- This study demonstrated that the Gas6(-/-) Axl(-/-) double knockout (DKO) mice showed axonal damage, motor deficits, prolonged neuroinflammation, and less remyelination following cuprizone exposure. PMID: 28925029
- Taken together, in our study Gas6 fails to aggravate calcification against the previous assumption. PMID: 27230889
- The present study provides evidence that the vitamin K-dependent protein growth arrest specific 6 (Gas6) promotes such repair in in vitro cultures of mouse optic nerve and cerebellum. PMID: 27630207
- Gas6/Axl and Akt/FoxO1a were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis. PMID: 27206970
- Gas6-mediated uptake is not a means to clear the bulk of circulating membrane-derived microparticles (PMPs) but may serve to locally phagocytose PMPs generated at sites of platelet activation and as a way to effect endothelial responses. PMID: 27006397
- Gas6-FoxO-1 signaling axis plays an important role in VCAM-1 expression in the context of venous thromboembolism by promoting bone marrow mononuclear cell-endothelial cell adhesion. PMID: 26414399
- Gas6 and Axl serum levels increase in parallel to chronic liver disease progression inactivation. PMID: 25908269
- Gas6, through upregulation of Ptges/PGE2, contributes to cancer-induced venous thrombosis. PMID: 26585956
- Gas6-induced Axl signaling is a critical driver of pancreatic cancer progression. PMID: 26206560
- Gas6/Axl signaling is essential for delaying the cellular senescence process regulated by the PI3K/Akt/FoxO signaling pathway. PMID: 25766527
- The up-regulation of Gas6/Axl signaling is a protective mechanism which reduces tubulo-interstitial apoptosis and slows progression to end-stage renal failure. PMID: 25019319
- Optimal TAM signaling requires coincident TAM ligand engagement of both its receptor and the phospholipid phosphatidylserine regulating TAM receptor tyrosine kinases Tyro3, Axl, and Mer and their ligands Gas6 and Protein S. PMID: 25265470
- Inhibition of the Gas6 receptor Mer or therapeutic targeting of Gas6 by warfarin reduced myeloma burden and improved survival in a systemic model of myeloma. PMID: 25102945
- data are consistent with Growth arrest-specific protein 6 being neuroprotective during experimental autoimmune encephalomyelitis by dampening the inflammatory response, thereby preserving axonal integrity and myelination. PMID: 25471571
- These results demonstrate that Gas6 enhances several features of fungal allergic airway disease. PMID: 24810144
- The expression of TAM receptor tyrosine kinases and their ligand Gas6 is markedly downregulated in psoriatic epidermis. These data are in concordance with earlier study, demonstrating that TAM-deficient mice develop systemic autoimmunity. PMID: 23684948
- Gas6 deficiency enhanced mouse colitis-associated tumorigenesis. PMID: 23430954
- Results demonstrate that Gas6 is a Mer ligand, and is active in Mer-driven phagocytosis in the retina. PMID: 23259948
- Alpha-lipoic acid attenuates vascular calcification by inhibiting vascular smooth muscle apoptosis through two distinct mechanisms; preservation of mitochondrial function via its antioxidant potential and restoration of the Gas6/Axl/Akt survival pathway. PMID: 21362131
- A self-regulatory mechanism of Toll-like receptor signalling through the suppression of Gas6 and ProS expression is described. PMID: 22043818
- results strongly suggest that 1) the Gas6 signaling itself is important to the cytoplasmic maturation, but not nuclear maturation. PMID: 21850267
- Study highlights the deleterious effect of Gas6 in the progression of steatosis to steatohepatitis and fibrosis. PMID: 21350191
- GAS6 enhances repair following cuprizone-induced demyelination PMID: 21203420
- These findings establish Gas6 as an important regulator of both central nervous system demyelination and remyelination. PMID: 21423702
- Gas6 and Tyro3, Axl and Mer (TAM) receptors have roles in human and murine platelet activation and thrombus stabilization PMID: 20546121
- Gas6 expression in macrophages was blocked by lipopolysaccharides (LPS), which also contributes to the inhibition of macrophage phagocytosis by LPS. PMID: 21039473
- The Gas6 pathway might be a potential nonimmunosuppressive target to minimize hepatic graft-versus-host disease in patients receiving allogeneic hematopoietic stem cell transplantation. PMID: 20139094
- IGF-I appears to be the primary proliferative signal in growth plate chondrocytes, whereas multiple factors including SCF, BDNF, and Gas6 regulate the pace of differentiation at the growth plate PMID: 19897599
- Gas6 induces glomerular cell proliferation in NTN and contributes to glomerular injury and the progression of chronic nephritis. PMID: 12122116
- Growth arrest-specific gene 6 is involved in glomerular hypertrophy in the early stage of diabetic nephropathy PMID: 12644472
- Gas6-Axl pathway in vascular smooth muscle cells is activated by hydrogen peroxide PMID: 15123721
- Data suggest that Gas6 is a unique growth factor for fibroblasts and post-translational gamma-carboxylation is necessary for its biological activity. PMID: 15184064
- Gas-6 enhances the accumulation of adipose tissue in diet-induced obese mice PMID: 15731491
- Akt/mTOR pathway is a key signaling cascade in Gas6-mediated mesangial and glomerular hypertrophy and there is a crucial role of Gas6/Axl and the Akt/mTOR pathway in the development of diabetic nephropathy PMID: 16014032
- These results suggested that GAS6 is an estrogen target gene in mammary epithelial cells. PMID: 17174935
- Gas6 signaling activated the phosphorylation of ERK1/2, SAPK/JNK, and Akt, but not p38 MAPK. These results suggest that Gas6 negatively regulates chondrogenic differentiation, at least through the MAPK pathway. PMID: 17459335
- Gas6 amplifies endothelial cell (EC) activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation. PMID: 18156494
- These observations provide insight into the mechanism by which Gas6 is downregulated during mesenchymal stem cells differentiation into chondrocytes. PMID: 18457663
- The expression profiles of Axl, Mer, and Gas6 mRNA were increased in the corpus callosum in a temporal profile correlating with the increased migration and proliferation of microglia/macrophages in this model. PMID: 18480276
- These findings identify a role for Gas6 in plaque composition and stability. PMID: 18570189
- AChE was observed to dock with Gas6, the ligand for Mer, as well as with apolipoprotein E3 (but not apolipoprotein E4), both at the same site as the laminin interaction PMID: 18785927
- Growth arrest-specific protein 6 deficiency impairs liver tissue repair after acute toxic hepatitis in mice. PMID: 19443073
- the expression pattern of Mer on macrophage subpopulations in the spleen and its Gas6-dependent role in macrophage phagocytosis suggest an important role for Mer in the modulation of immune responses. PMID: 19631584
顯示更多
收起更多
-
亞細胞定位:Secreted.
-
數(shù)據(jù)庫鏈接:
Most popular with customers
-
Recombinant Human Tumor necrosis factor ligand superfamily member 8 (TNFSF8), partial (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Mouse Semaphorin-4D (Sema4d), partial (Active)
Express system: Mammalian cell
Species: Mus musculus (Mouse)
-
Recombinant Human C-X-C chemokine receptor type 4 (CXCR4)-VLPs (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Human Dickkopf-related protein 1 (DKK1) (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Human Dipeptidase 3(DPEP3), partial (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Mouse Cadherin-6(Cdh6),partial (Active)
Express system: Mammalian cell
Species: Mus musculus (Mouse)