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  4. Recombinant Mouse Filamin-B (Flnb), partial

Recombinant Mouse Filamin-B (Flnb), partial

  • 中文名稱(chēng)：
    小鼠Flnb重組蛋白
  • 貨號(hào)：
    CSB-YP800356MO
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱(chēng)：
    小鼠Flnb重組蛋白
  • 貨號(hào)：
    CSB-EP800356MO
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱(chēng)：
    小鼠Flnb重組蛋白
  • 貨號(hào)：
    CSB-EP800356MO-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱(chēng)：
    小鼠Flnb重組蛋白
  • 貨號(hào)：
    CSB-BP800356MO
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱(chēng)：
    小鼠Flnb重組蛋白
  • 貨號(hào)：
    CSB-MP800356MO
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Flnb
  • Uniprot No.：
  • 別名：
    FlnbFilamin-B; FLN-B; ABP-280-like protein; Actin-binding-like protein; Beta-filamin
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton.
  • 基因功能參考文獻(xiàn)：
    1. this study finds highest filamin B editing levels in skeletal muscles, cartilage and bones, tissues where Filamin B function seems most important. PMID: 30064337
    2. These findings indicate that FLNB is involved in attenuation of TGFb/BMP signaling and influences annulus fibrosus cell fate PMID: 27019229
    3. Fmn1 and FlnB have shared and independent functions. PMID: 24760772
    4. FlnB loss reduced Cdk1 phosphorylation (an inhibitor of G2/M phase progression) and Cdk1 inhibition in chondrocytes mimicked the null FlnB, premature differentiation phenotype, through a beta1-integrin receptor- Pi3k/Akt mediated pathway. PMID: 24551245
    5. Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development PMID: 17360453
    6. disruption of the ECM-beta1-integrin-Flnb pathway contributes to defects in vertebral and distal limb development, similar to those seen in the human autosomal recessive SCT due to Flnb mutations PMID: 17510210
    7. Flnb represses chondrocyte hypertrophy in a Runx2/Smad3-dependent manner. PMID: 17606870
    8. Disruption of the Flnb gene in mice phenocopies the human disease spondylocarpotarsal synotosis syndrome. PMID: 17635842

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  • 亞細(xì)胞定位：
    Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, myofibril, sarcomere, Z line.
  • 蛋白家族：
    Filamin family
  • 組織特異性：
    Expressed in hippocampus, cortex, cerebellar Purkinje cells and granule cell layers.
  • 數(shù)據(jù)庫(kù)鏈接：