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  4. Recombinant Human Protein DEK (DEK)

Recombinant Human Protein DEK (DEK)

In Stock
  • 中文名稱(chēng)：
  • 貨號(hào)：
    CSB-BP006710HU
  • 規(guī)格：
    ￥3168
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    DEK
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Full Length of Mature Protein
  • 來(lái)源：
    Baculovirus
  • 分子量：
    46.4 kDa
  • 表達(dá)區(qū)域：
    2-375aa
  • 氨基酸序列
    SASAPAAEGEGTPTQPASEKEPEMPGPREESEEEEDEDDEEEEEEEKEKSLIVEGKREKKKVERLTMQVSSLQREPFTIAQGKGQKLCEIERIHFFLSKKKTDELRNLHKLLYNRPGTVSSLKKNVGQFSGFPFEKGSVQYKKKEEMLKKFRNAMLKSICEVLDLERSGVNSELVKRILNFLMHPKPSGKPLPKSKKTCSKGSKKERNSSGMARKAKRTKCPEILSDESSSDEDEKKNKEESSDDEDKESEEEPPKKTAKREKPKQKATSKSKKSVKSANVKKADSSTTKKNQNSSKKESESEDSSDDEPLIKKLKKPPTDEELKETIKKLLASANLEEVTMKQICKKVYENYPTYDLTERKDFIKTTVKELIS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in chromatin organization.
  • 基因功能參考文獻(xiàn)：
    1. These findings define DEK as an important and multifunctional mediator of homologous recombination. PMID: 28317934
    2. DEK is detected in spontaneously forming neutrophil extracellular traps (NETs) from juvenile idiopathic arthritis patient synovial neutrophils, and DEK-targeted aptamers reduce NETs formation. PMID: 28165452
    3. High DEK proto-oncogene protein (DEK) expression associated with complete response to neoadjuvant chemoradiotherapy. PMID: 29409457
    4. High DEK expression is associated with cervical cancer tumorigenesis and metastasis. PMID: 28627610
    5. The results of the present study demonstrated that EMT of colorectal carcinoma cells was partially mediated by DEK, which likely affected the invasive ability of colorectal carcinoma cells. In addition, cell proliferation and apoptosis were susceptible to DEK silencing. PMID: 29115492
    6. RNA-sequencing proved to be a valuable tool for the detection of a fusion of genes DEK and NUP214 in a leukemia that showed cryptic cytogenetic rearrangement of chromosome band 9q34. PMID: 29109093
    7. DEK overexpression enhanced carcinogenesis, including field cancerization, in OSCC by stimulating the G1 /S phase transition and promoting DNA replication. PMID: 28834425
    8. DEK and LCMR1 were demonstrated to cooperate in the inhibition of apoptosis in lung cancer cells. PMID: 28765911
    9. High DEK expression is associated with breast cancer angiogenesis . PMID: 26988756
    10. our study indicates that DEK expression is required for tumorigenesis and metastasis of hepatocellular carcinoma PMID: 27057626
    11. High DEK expression is associated with melanoma progression. PMID: 27893188
    12. DEK correlates with IL6 expression in HPV16+/p16+ oropharyngeal squamous cell carcinomas (OPSCC). PMID: 28423581
    13. data support a scenario whereby overexpression of the human DEK oncogene reprograms keratinocyte metabolism to fulfill energy and macromolecule demands required to enable and sustain cancer cell growth PMID: 28558019
    14. Decreased DEK expression in plasma cells suggests a potential role of this gene in plasma cell development and lack of detectable DEK protein by IHC could be used as a biomarker for normal and malignant plasma cells PMID: 28558048
    15. Our data indicated DEK plays multiple roles to facilitate tumor growth and maintenance. It can be used as a potential target for astrocytic tumor diagnosis and gene therapy. PMID: 28670979
    16. High DEK expression is associated with pancreatic ductal adenocarcinoma. PMID: 27959420
    17. AP-2a is an important transcription factor of DEK expression, which is correlated with the methylation level of the DEK core promoter in hepatocellular carcinoma . PMID: 27499261
    18. miR-592 targets DEK transcript and suppresses hepatocellular carcinoma cell growth PMID: 26722432
    19. Results find that DEK binds to transcription start sites with a dual role in activation and repression of highly and ubiquitously expressed genes. PMID: 25216995
    20. The study identified the DEK oncoprotein as a critical factor that interacts with an essential upstream enhancer element of the EKLF promoter and exerts a positive effect on EKLF levels. PMID: 26303528
    21. DEK promotes the growth of colorectal cancer and apoptosis PMID: 25340858
    22. Data show that oncoprotein DEK facilitates cellular proliferation under conditions of DNA replication stress by promoting replication fork progression. PMID: 25347734
    23. The results show that several leukemia-associated fusion genes cause an increase in DEK protein expression. PMID: 25524609
    24. DEK expression during normal hematopoiesis did reveal a relationship with specific cell types implicating a distinct function during myeloid differentiation PMID: 25128083
    25. These data suggest DEK overexpression as a crucial event for the emergence of an aggressive phenotype in colorectal cancer. PMID: 25515240
    26. Studies demonstrate that DEK overexpression, due in part to Ron receptor activation, drives breast cancer progression through the induction of Wnt/beta-catenin signaling. PMID: 24954505
    27. DEK plays an important role in the progression of small cell lung cancer PMID: 25197373
    28. Results highlight a novel function of DEK as a guardian of chromatin by restricting widespread histone access, and in particular by modulating differential H3.3 loading in specific chromatin areas. PMID: 25049225
    29. t(6;9)/DEK-NUP214 represents a unique subtype of acute myeloid leukemia with a high risk of relapse. PMID: 24441146
    30. data demonstrate that DEK stimulates HNSCC cellular growth and identify DeltaNp63 as a novel DEK effector PMID: 24608431
    31. DEK is an hTERT repressor shared by various leukemia subtypes that may be involved in the deregulation of numerous genes associated with leukemogenesis PMID: 24563617
    32. High level of DEK protein expression predicts the poor prognosis of patients with gastric cancer PMID: 24650035
    33. the expression of the fusion gene DEK-NUP214 leads to increased cellular proliferation. We show that this is dependent on upregulation of the signal transduction protein mTOR with subsequent effects on protein synthesis and glucose metabolism. PMID: 24073922
    34. DEK plays an important role in the progression of colorectal cancers and it is an independent poor prognostic factor of colorectal cancers PMID: 23902796
    35. DEK depletion inhibited cellular migration in lung cancer cell lines possibly through inactivation of the RhoA/ROCK/MLC signal transduction pathway PMID: 23571382
    36. Full-length DEK secreted by one cell can be taken up by another cell, move to the nucleus, and function in heterochromatin biology and DNA repair, thereby potentially uniting the intracellular and extracellular activities of DEK. PMID: 23569252
    37. increased expression of DEK in chronic lymphocytic leukemia correlates with immunoglobulin heavy chain variable gene mutational status, CD38-positive and del(17p13), and DEK can therefore be considered as potential prognostic factor. PMID: 23052131
    38. DEK promotes the pathogenesis of estrogen receptor positive breast cancer. PMID: 23071688
    39. DEK may be involved in the pathogenesis of Merkel cell carcinoma and therefore may provide therapeutic implications for Merkel cell carcinomas. PMID: 22765016
    40. DEK has potent effects on HSCs, HPCs, and hematopoiesis, information of biological and potential clinical interest. PMID: 21943234
    41. C/EBPalpha and DEK coordinately activate myeloid gene expression. PMID: 22474248
    42. DEK knockdown results in a significant growth repression of CaSki cells by inducing cell apoptosis and senescence via upregulation of p65. PMID: 22390170
    43. DEK overexpression appears to be associated with breast cancer progression PMID: 22360505
    44. DEK is important for DNA double-strand break repair. PMID: 21653549
    45. DEK protein is expressed in bladder tumor tissue and voided urine of bladder cancer patients. PMID: 21663673
    46. DEK overexpression may be a frequent event in invasive melanomas, and further augmentation of DEK expression may be associated with the acquisition of ominous features such as deep dermal invasion and metastasis. PMID: 21316078
    47. data indicate that DEK expression stimulates the growth, stem cell character and motility of breast cancer cells, and that DEK-dependent cellular invasion occurs at least in part via beta-catenin activation PMID: 21317931
    48. identify the oncoprotein DEK, an abundant nuclear protein with a previously enigmatic in vivo function, as a Suppressor of Variegation [Su(var)] that is crucial to global heterochromatin integrity PMID: 21460035
    49. DEK can contribute directly to joint inflammation in juvenile idiopathic arthritis by generating ICs through high-affinity interaction between DEK and DEK autoantibodies. PMID: 21280010
    50. DEK overexpression, partly through an increase in its gene dose, mediates the activity of global transcriptional regulators and is associated with tumor initiation activity and poor prognosis in high grade neuroendocrine carcinoma of the lung. PMID: 20543864

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  • 相關(guān)疾?。?/div>
    A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia (PubMed:1549122). Translocation t(6;9)(p23;q34) with NUP214/CAN (PubMed:1549122). It results in the formation of a DEK-NUP214 fusion gene (PubMed:1549122).
  • 亞細(xì)胞定位：
    Nucleus. Note=Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei.
  • 組織特異性：
    Ubiquitous. Expressed at relatively high levels.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 2768

    OMIM: 125264

    KEGG: hsa:7913

    STRING: 9606.ENSP00000380414

    UniGene: Hs.484813