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  4. Recombinant Human Oxytocin-neurophysin 1 (OXT)

Recombinant Human Oxytocin-neurophysin 1 (OXT)

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  • 中文名稱：
    人OXT重組蛋白
  • 貨號(hào)：
    CSB-YP017315HU
  • 規(guī)格：
    ￥2208
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 別名：
    OXT; OT; Oxytocin-neurophysin 1; OT-NPI) [Cleaved into: Oxytocin; Ocytocin); Neurophysin 1]
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 來(lái)源：
    Yeast
  • 分子量：
    11.6kDa
  • 表達(dá)區(qū)域：
    32-125aa
  • 氨基酸序列
    AAPDLDVRKCLPCGPGGKGRCFGPNICCAEELGCFVGTAEALRCQEENYLPSPCQSGQKACGSGGRCAVLGLCCSPDGCHADPACDAEATFSQR
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Tris-based buffer,50% glycerol
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Neurophysin 1 specifically binds oxytocin.; Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR).
  • 基因功能參考文獻(xiàn)：
    1. The results suggest that there is an age-dependent association between visual attention for social cues and oxytocin (OT) levels in infants and children, and that the development of visual attention to the eyes as social cues is associated with both OXTR polymorphisms and OT levels. PMID: 28566712
    2. Although some SNPs were associated at an alpha level of .05 with breastfeeding, they did not survive multiple testing correction. Authors conclude that SNPs within or nearby OXT and OXTR are unlikely to have large effects on breastfeeding behavior. PMID: 29412506
    3. Oxytocin gene polymorphisms and parenting G x E interaction on social anxiety levels in adolescents. PMID: 28606214
    4. serum oxytocin levels were higher among women than men and were negatively associated with strength of belief in life after death PMID: 26898770
    5. A significant moderating effect of OXT genotype (rs2740210) on the relationship between social support and psychiatric distress was detected PMID: 29040351
    6. findings suggested more significant plasma oxytocin dysregulation in the patients in the bipolar II disorder group than in the major depressive disorder patients and controls, both before and after treatment PMID: 28865715
    7. Oxytocin level did not vary significantly between healthy controls, healthy controls with a history of sexual abuse, and psychogenic non-epileptic seizure patients with a history of sexual abuse. PMID: 28927333
    8. These results suggest that OXT and OXTR are controlled mainly by E2 in the placenta via ESR1 and thus may play physiological functions in the human placenta during the late stage of pregnancy. PMID: 28694300
    9. Study found a higher expression of paraventricular nucleus OXT in the mood disorder patients than in the control subjects, and observed a clear co-localization of androgen receptor in OXT-expressing neurons, both in the cytoplasm and in the nucleus. In addition, a significant decrease in OXT-mRNA levels was observed after pre-incubation of the SK-N-SH cells with testosterone. PMID: 28447621
    10. Serum and prostatic oxytocin levels are increased in the PCa subjects. Serum oxytocin level may be a biomarker for PCa in the future. Oxytocin increases PCa growth and APPL1 expression. PMID: 28415720
    11. Obese children had significantly higher irisin and lower oxytocin levels than the healthy controls. PMID: 28077341
    12. study found that rs6133010 in the OXT gene is associated with alcohol dependence in the northern Chinese Han population PMID: 27818356
    13. OXT levels were lowest in anorexia nervosa, higher in healthy controls, and highest in obesity. There were positive associations between OXT and body mass index, total, visceral, and subcutaneous fat, and bone mineral density. PMID: 28586943
    14. epigenetic modification of OXT is linked to several overt measures of sociability PMID: 27325757
    15. Hormonal changes in estradiol, progesterone, or oxytocin do not predict differences in the pain perception of women in the peripartum or postpartum period. PMID: 27028773
    16. Oxytocin prevents cartilage matrix destruction via regulating MMP1 and MMP13. PMID: 28238786
    17. Low oxytocin expression is associated with diabetic metabolic syndrome. PMID: 27578619
    18. Oxytocin levels were lower in autistic patients compared to controls. PMID: 26739971
    19. Children with Prader-Willi syndrome have elevated plasma oxytocin levels. PMID: 26615966
    20. This is the first known study to show a significant association between callous unemotional traits in children and adolescents with extreme, persistent pervasive aggression and a polymorphism on the oxytocin receptor. PMID: 22294460
    21. Oxytocin serum levels with Attention Deficit Hyperactivity Disorder were significantly decreased compared with controls. PMID: 26168929
    22. reviews the role of OT in the control mechanisms of sexual behavior. PMID: 25088178
    23. Oxytocin activates NF-kappaB-mediated inflammatory pathways in human gestational tissues in normal parturition. PMID: 25451977
    24. Report for the first time of a significant genetic association of OXT and AVP with schizophrenia PMID: 21899794
    25. nominal associations were found between autism spectrum disorder scores and single-nucleotide polymorphisms in OXT, ARNT2 and CD38 PMID: 24635660
    26. findings suggest that experiences of childhood emotional maltreatment may alter salivary oxytocin levels, which in turn are related to more positive perceptions of infant stimuli with positive emotion PMID: 24768649
    27. Patients with poor outcome after aneurysmal subarachnoid hemorrhage have lower AVP and OXT levels in cerebrospinal fluid. PMID: 24412107
    28. dysregulation of OXT, AVP and/or testosterone systems exist in mothers of autistic children. PMID: 24086383
    29. OXT rs2740210 interacted with early life adversity to predict variation in breastfeeding duration and postpartum depression. PMID: 23941164
    30. Women with low OT may not effectively interpret and utilize available support resources, which may be associated with sleep disturbances PMID: 23799864
    31. Oxytocin plays an important role in modulation of social bonding processes and stress regulation, and may be crucially involved in the promotion of mental health. Review. PMID: 23856187
    32. Data from women undergoing hysterectomy for uterine fibroids suggest that uterine isthmian-cervical myoma pseudocapsules exhibit substantial nerve fibers expressing OXT; uterine fundal myoma pseudocapsules exhibit few nerve fibers expressing OXT. PMID: 23937196
    33. Data suggest that that OXT enhances pro-social behavior by influencing complex brain networks involved in self-referential processing and affectionate touch, most prominently in individuals with supportive family experiences in childhood. PMID: 23453164
    34. findings suggest that oxytocin might not promote human bond formation in ways analogous to prairie voles - that is, by inducing a partner preference effect PMID: 22920910
    35. OT increases covert attention to happy faces, thereby supporting the hypothesis that OT modulates early attentional processes that might promote prosocial behavior in healthy men. PMID: 23146328
    36. In couples, relationship quality had a small, marginally significant inverse association with plasma oxytocin levels. PMID: 22543270
    37. polymorphisms in OXT associate with both infant-directed vocalizing and maternal instrumental care. PMID: 23637833
    38. Results indicate that oxytocin, beyond its role in social bonding, regulates non-homeostatic, reward-related energy intake, hypothalamic-pituitary-adrenal axis activity, and the glucoregulatory response to food intake in humans. PMID: 23835346
    39. OT inhibits neuroadaptation to and withdrawal from alcohol. PMID: 23025690
    40. OT is a regulator of the PI3K/Akt/mTORC1 pathway in Caco2BB cells and may modulate translation in gut cells. PMID: 23410756
    41. kisspeptin-10 transiently excites oxytocin neurons in late pregnancy and during lactation, suggesting that a central kisspeptin excitation of oxytocin neurons emerges at the end of pregnancy PMID: 23550008
    42. Women who perceived low cognitive social capital showed higher oxytocin levels, while structural social capital showed inverse-U shape association with oxytocin. No association between oxytocin and social capital was found among men. PMID: 23284856
    43. oxytocin and argipressin have been referred to as "social" neuropeptides as they have a highly conserved role as mediators of complex social cognition and interaction in both animals and humans PMID: 23589638
    44. The study links defense-motivated competition to oxytocin, a hypothalamic neuropeptide involved in reproduction and social bonding. PMID: 23144787
    45. Results show low plasma oxytocin levels in patients with generalized social anxiety disorder compared to controls during a prosocial laboratory task paradigm. PMID: 22807189
    46. Data suggest that nocturnal oxytocin secretion is low in amenorrheic athletes compared with nonathletes and is associated with site-dependent microarchitectural parameters of bone (tibia [weight-bearing]; radius [non-weight-bearing]). PMID: 23258269
    47. [review] The OT system functions as an important element within a complex, developmentally sensitive biobehavioral system. PMID: 21984889
    48. Data suggest that plasma oxytocin is lower in subjects with uncontrolled type 2 diabetes along with psychoticism, somatization, or obsessionality as compared with subjects with controlled type 2 diabetes. PMID: 22997507
    49. first evidence or relationship between plasma oxytocin level and expression of SERT (serotonin transporter) on platelet membranes PMID: 22297159
    50. Oxytocin may be involved in the pathophysiology of anorexia. PMID: 22872688

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Vasopressin/oxytocin family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 8528

    OMIM: 167050

    KEGG: hsa:5020

    STRING: 9606.ENSP00000217386

    UniGene: Hs.113216