Recombinant Human Melanoma-associated antigen B2 (MAGEB2)
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中文名稱:人MAGEB2重組蛋白
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貨號:CSB-BP013342HU
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規(guī)格:¥3168
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功能:May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.
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基因功能參考文獻:
- MAGEB2 can be aberrantly demethylated and expressed in malignant peripheral nerve sheath tumors. Conversely, the gene may not be demethylated in any types of neurofibroma, suggesting that the demethylation does not occur before malignant transformation. PMID: 26642794
- MageB2 counteracts E2F inhibition by ribosomal proteins independently of Mdm2 expression PMID: 26468294
- we identified MAGEB2 as activated by promoter demethylation in HNSCCand demonstrates growth promoting effects in a minimally transformed oral keratinocyte cell line. PMID: 23029077
- Valproic acid causes a change in acetylation of this gene. PMID: 17012225
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組織特異性:Expressed in testis and placenta, and in a significant fraction of tumors of various histologic types.
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