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Recombinant Human Melanoma-associated antigen 9 (MAGEA9)

  • 中文名稱：
    人MAGEA9重組蛋白
  • 貨號：
    CSB-YP013335HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MAGEA9重組蛋白
  • 貨號：
    CSB-EP013335HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MAGEA9重組蛋白
  • 貨號：
    CSB-EP013335HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MAGEA9重組蛋白
  • 貨號：
    CSB-BP013335HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MAGEA9重組蛋白
  • 貨號：
    CSB-MP013335HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MAGEA9
  • Uniprot No.：
  • 別名：
    Cancer/testis antigen 1.9; Cancer/testis antigen family 1 member 9; CT1.9; MAGA9_HUMAN; MAGE 9 antigen; MAGE-9 antigen; MAGE9; MAGEA9A; MAGEA9B; Melanoma antigen family A 9; Melanoma associated antigen 9; Melanoma-associated antigen 9; MGC8421
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達(dá)區(qū)域：
    1-315
  • 氨基酸序列
    MSLEQRSPHC KPDEDLEAQG EDLGLMGAQE PTGEEEETTS SSDSKEEEVS AAGSSSPPQS PQGGASSSIS VYYTLWSQFD EGSSSQEEEE PSSSVDPAQL EFMFQEALKL KVAELVHFLL HKYRVKEPVT KAEMLESVIK NYKRYFPVIF GKASEFMQVI FGTDVKEVDP AGHSYILVTA LGLSCDSMLG DGHSMPKAAL LIIVLGVILT KDNCAPEEVI WEALSVMGVY VGKEHMFYGE PRKLLTQDWV QENYLEYRQV PGSDPAHYEF LWGSKAHAET SYEKVINYLV MLNAREPICY PSLYEEVLGE EQEGV
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
  • 基因功能參考文獻(xiàn)：
    1. MAGE-A9 overexpression promoted cell proliferation, colony formation, migration, chemoresistance, and tumorigenicity in the context of EpCAM+ HCC cells, whereas MAGE-A9 knockdown significantly inhibited anchorage-dependent and spheroid colony formation and in vivo tumorigenicity. PMID: 29138811
    2. potential X-linked candidate for the CNV67-related spermatogenic failure phenotype PMID: 28339631
    3. High expression levels of MAGE-A9 are correlated with lung adenocarcinoma. PMID: 26717042
    4. The results showed that the high expression of MAGE-A9 protein in NSCLC tumor cells were commonly present in squamous cell carcinomas. It was also related to larger tumor diameter, lymph node metastasis and later stage grouping with TNM classification PMID: 25755744
    5. These data are the first to indicate that MAGE-A9 expression is a valuable prognostic biomarker for HCC and that high MAGE-A9 expression suggests unfavorable survival outcomes in HCC patients PMID: 25315972
    6. High expression of MAGE-A9 indicates unfavorable survival outcome in laryngeal squamous cell carcinoma patients. PMID: 25400753
    7. The data suggest that MAGE-A9 expression is correlated with malignant attributes of invasive ductal breast cancer PMID: 25445503
    8. MAGE-A9 and MAGE-A11 are tumor-specific antigens and not only DNA hypermethylation but also histone deacetylation is responsible for the mechanism underlying MAGE-A9 and MAGE-A11 gene silencing. PMID: 24316396
    9. May provide suitable targets for immunotherapy of renal cell carcinoma. PMID: 15900605
    10. Overexpression of MAGE-A9 is associated with bladder cancer. PMID: 19533752

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  • 組織特異性：
    Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6807

    OMIM: 300342

    KEGG: hsa:4108

    STRING: 9606.ENSP00000298974

    UniGene: Hs.460974