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  4. Recombinant Human Mannose-binding protein C (MBL2)

Recombinant Human Mannose-binding protein C (MBL2)

  • 中文名稱：
    人MBL2重組蛋白
  • 貨號(hào)：
    CSB-YP013540HU
  • 規(guī)格：
    ￥1500
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 別名：
    COLEC 1; COLEC1; Collectin-1; HSMBPC; Lectin; mannose-binding; soluble; 2; Mannan binding lectin; Mannan binding protein; Mannan-binding protein; Mannose binding lectin (protein C) 2 soluble; Mannose binding lectin (protein C) 2; soluble (opsonic defect); Mannose binding lectin (protein C) 2; soluble; Mannose binding lectin 2 soluble; Mannose binding lectin 2; soluble (opsonic defect); Mannose binding lectin; Mannose binding lectin protein C2 soluble opsonic defect; Mannose binding protein; Mannose binding protein C; Mannose binding protein C precursor ; Mannose binding protein; serum; Mannose-binding lectin; Mannose-binding protein C; MBL 2; MBL; MBL2; MBL2_HUMAN; MBL2D; MBP 1; MBP; MBP C; MBP-C; MBP1; MBPB; MBPC; MBPD; MGC116832; MGC116833; Opsonic defect; protein C; Soluble mannose binding lectin
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 來源：
    Yeast
  • 分子量：
    26.0kDa
  • 表達(dá)區(qū)域：
    21-248aa
  • 氨基酸序列
    ETVTCEDAQKTCPAVIACSSPGINGFPGKDGRDGTKGEKGEPGQGLRGLQGPPGKLGPPGNPGPSGSPGPKGQKGDPGKSPDGDSSLAASERKALQTEMARIKKWLTFSLGKQVGNKFFLTNGEIMTFEKVKALCVKFQASVATPRNAAENGAIQNLIKEEAFLGITDEKTEGQFVDLTGNRLTYTNWNEGEPNNAGSDEDCVLLLKNGQWNDVPCSTSHLAVCEFPI
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Tris-based buffer,50% glycerol
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.
  • 基因功能參考文獻(xiàn)：
    1. These findings suggest that high activity of the classical complement pathway, and MBL deficiency, might be associated with an increased odds of unprovoked venous thromboembolism, independent of activation of Tissue Factor-induced coagulation. PMID: 30015228
    2. he carrying of MBL2 exon 1 codon 54 variant allele (B) was shown to be a risk factor for Recurrent vulvovaginal candidiasis in childbearing women. PMID: 29850562
    3. Positive correlation of MBL levels with anti-ds DNA titers in systemic lupus erythematosus suggest that its values vary with activity and could be a potential biomarker of the disease. PMID: 29314753
    4. The -221G>C polymorphism of MBL2, the -159C>T polymorphism of CD14 and the TNF-857 polymorphism of TNF-a are risk factors for spinal spinal tuberculosis (TB) and may be involved in the development of spinal TB in the Chinese population. These factors are indicators of susceptibility to spinal TB and require clinical attention. PMID: 29298876
    5. MBL2 protein blood level was significantly reduced in the hepatocellular carcinoma patients.The association in MBL2 polymorphisms and the risk of hepatocellular carcinoma. PMID: 27557564
    6. Results suggested the involvement of MBL2 (rs1800450) polymorphism and its protein in rheumatic heart disease pathogenesis. PMID: 29653582
    7. MBL deficiency was significantly more frequent in the juvenile idiopathic arthritis Yersinia-reactive antibodies-positive group than in patients without Yersinia-reactive antibodies or in controls PMID: 28405017
    8. it can be concluded that molecular analysis of MBL rs1800450 AA genotype and TNF-alpha rs1800620 AA genotype is important in the early detection and treatment of T2DM with H. pylori cagA(+) infection. PMID: 29053425
    9. The results suggest that MBL deficiency and the presence of MBL2 gene polymorphisms that lead to MBL deficiency are risk factors for the occurrence of miscarriage in patients with RA. PMID: 28898115
    10. These results suggest that the MBL2 gene Codon 54 and TNF-alpha gene G308A polymorphisms are not associated with an increased risk for development of tuberculosis in our patients. PMID: 28189510
    11. Studies results provide evidence that Crohn's disease patients have an impairment in mannose-binding lectin-mannose-associated serine protease functional activity and that this defect is associated with mannose-binding lectin 2 and NOD2 variants. PMID: 27404661
    12. Our data do not support a possible role for MBL2 polymorphisms in the pathogenesis and in the clinical manifestations of rheumatic fever. PMID: 28576308
    13. The reduced expression of functional MBL secondary to having MBL2 variants may partially mediate the increased susceptibility to TB risk. PMID: 27812036
    14. MBL2 rs1800450 and rs1800451 polymorphisms play a protective role in TB infection and reinforce their critical significance as a potential genetic marker for TB resistance. PMID: 27876780
    15. genetic variants facilitate extended periodontal inflammation and destruction by Aggregatibacter actinomycetemcomitans PMID: 27624657
    16. MBL2 exon 1 polymorphic variants were found only in codon 54, and the allele frequencies did not differ significantly between the control and disease groups PMID: 28558668
    17. These results indicated that polymorphisms in MBL2 gene may influence susceptibility, progression and prognosis of HBV-related liver diseases. PMID: 26857650
    18. The article data indicate that rs11003125 in the MBL2 (Mannose Binding Lectin 2) gene was shown to be associated with a high prevalence of caries in our cohort, and 2 haplotypes are also involved in the increased susceptibility to dental caries. PMID: 27894112
    19. the findings of the current study obtained on mother and children from Zambia evidence lack of association between MBL2 functional polymorphisms and HIV-1 mother-to-child transmission PMID: 26740328
    20. Mannose-binding lectin levels are largely genetically determined. This relationship was preserved in children during critical illness, despite the effect of large-volume fluid administration on mannose-binding lectin levels. Mannose-binding lectin levels had no association with infection status at admission, or with progression from systemic inflammatory response syndrome to sepsis or septic shock. PMID: 27820718
    21. Low MBL levels are associated with a higher risk for future cardiac events and cardiovascular events. PMID: 27495980
    22. results showed that despite MBL2 gene polymorphisms being associated with the protein plasma levels, the polymorphisms were not enough to predict the development of heart disease, regardless of infection with both species of Chlamydia. PMID: 27982280
    23. MBL2 polymorphisms are associated with higher incidence of development of coronary in-stent restenosis. PMID: 28056798
    24. MBL2 gene exon1 polymorphisms are associated with increased risk of high-risk HPV infection and cervical cancer development among Caucasians (Meta-Analysis) PMID: 27619685
    25. these data support the concept that rhMBL may serve a protective innate host response and a critical biological response modifier function by limiting AM inflammation, oxidative injury, and AM apoptosis, which may allow effective IAV clearance while limiting collateral damage to vital organs, such as the lungs. PMID: 24399838
    26. In a large cohort of VLBWI MBL2 deficiency had no major impact on infection risk unless children were born between 32 0/7 and 36 6/7 weeks of gestation PMID: 28558032
    27. The results suggest that the mutations in exon 1 of the MBL2 gene do not contribute directly to the clinical and laboratory features of HCV and HBV infections, but further studies should be performed to confirm whether the wild AA genotype has indirect effect on disease progression. PMID: 28408790
    28. binding of dengue virus NS1 to MBL protects dengue virus against mannose-binding lectin-mediated neutralization by the lectin pathway of complement activation PMID: 27798151
    29. study provides evidence for an important role for the lectin pathway in the inflammatory response induced by cholesterol crystals (CC) and emphasize the role of ficolin-2 and MBL in the CC-mediated inflammation occurring during atherosclerotic plaque development PMID: 27183610
    30. In our meta-analysis, no significant association was found between MBL2 codon 54 A/B, -550 H/L, or -221 X/Y gene polymorphisms and the risk of asthma under 5 genetic models PMID: 27590640
    31. MBL2 genotype association with meningococcal disease was not statistically significant. PMID: 27351742
    32. The SNP genotypes of MBL2 influence the plasma levels of MBL. However, there is a wide range in MBL levels for a specific genotype of MBL2 during pregnancy indicating that a low second-trimester plasma MBL level is not a marker for the development of preterm birth. PMID: 27124763
    33. We have identified two single-nucleotide polymorphisms in two immune-related genes (MBL2 and CD95) that have an association with severe and potentially life-threatening infection following doxorubicin and cyclophosphamide therapy for breast cancer. PMID: 27940354
    34. this study shows that collectin may aid clearance of influenza A virus by promoting monocyte uptake of the virus, while reducing viral replication and virus-induced TNF-a responses in these cells PMID: 27856789
    35. findings suggest that complement activation mediated by MBL contributes to the pathogenesis and also severity of Multiple sclerosis, Myasthenia gravis, and Guillain-Barre Syndrome . PMID: 27424141
    36. Studied the relationship between polymorphisms in MBL, TLR1, TLR2 and TLR6 encoding genes and stimulated IFN-gamma and IL-12 ex vivo production in BCG osteitis survivors. Found that variant genotypes of the MBL2 gene (if homozygous) and variant genotypes of the TLR2 gene (only heterozygotes present) are associated with low IFN-gamma production. PMID: 27755461
    37. this study shows that MBL2 polymorphisms is not a major risk factor for community-acquired pneumonia in general, but patients with genotypes corresponding with high serum MBL levels are at risk for atypical pneumonia PMID: 28032346
    38. MBL-deficient individuals with additional lectin pathway pattern recognition molecular defects may be at risk to morbidity. PMID: 26795763
    39. MBL2 polymorphisms were associated with an increased and TLR7 polymorphisms with a decreased risk of rhinovirus-associated acute otitis media. PMID: 28403045
    40. MBL2 rs11003123 polymorphism may be a marker for the risk of hepatocellular carcinoma occurrence in patients with HBV-related cirrhosis in the Chinese population. PMID: 27298104
    41. this study shows that MBL levels may be linked with the occurrence of spondyloarthritis in Brazilian patients PMID: 27911110
    42. Low baseline MBL levels were correlated with high risk of gram-negative bacteremia; however, no significant correlation was shown in the follow-up. PMID: 26377840
    43. These results indicate that the mycobacterial antigen 85 complex is a target for ficolins and mannose-binding lectin. PMID: 27141819
    44. In type 1 diabetic patient, evaluated serum levels of MBL can be seen as an independent marker of diabetic nephropathy even after correcting for possible confounding factors. PMID: 26212019
    45. association between C + 4T (P/Q) gene polymorphism and oropharyngeal tularemia PMID: 27223255
    46. this study shoes that Brazilian patients carrying genotypes or haplotypes of low production of MBL would be more susceptible to dengue haemorrhagic fever PMID: 27180198
    47. Low MBL serum levels and deficient MBL2 diplotypes were associated with a higher incidence of acute cellular rejection during the first year after kidney transplantation. PMID: 26924055
    48. this study shows the role of MBL2 polymorphisms in hepatitis C infection susceptibility in Italy PMID: 27136459
    49. Preterm infants who had low levels of MBL at admission are exposed to an increased risk of adverse neurological outcomes. PMID: 26153116
    50. Variant A allele in MBL2 gene rs1800450 polymorphism might increase the risk of sepsis via decrease the MBL serum level PMID: 26823854

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  • 亞細(xì)胞定位：
    Secreted.
  • 組織特異性：
    Plasma protein produced mainly in the liver.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6922

    OMIM: 154545

    KEGG: hsa:4153

    STRING: 9606.ENSP00000363079

    UniGene: Hs.499674