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  4. Recombinant Human Major vault protein (MVP)

Recombinant Human Major vault protein (MVP)

  • 中文名稱：
    人MVP重組蛋白
  • 貨號：
    CSB-EP015248HU
  • 規(guī)格：
    ￥1344
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    MVP
  • Uniprot No.：
  • 別名：
    LRP; Lung resistance related protein; Lung resistance-related protein; Major vault protein; Major vault protein; rat; homolog of; MVP; MVP_HUMAN; testicular secretory protein Li 30; VAULT 1; VAULT1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 來源：
    E.coli
  • 分子量：
    115.2kDa
  • 表達(dá)區(qū)域：
    2-893aa
  • 氨基酸序列
    ATEEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCTVANPVSRDAQGLVLFDVTGQVRLRHADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTALHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVVEIIQATIIRQNQALRLRARKECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRDFRGVSRRTGEEWLVTVQDTEAHVPDVHEEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKRVVKGEKSFFLQPGEQLEQGIQDVYVLSEQQGLLLRALQPLEEGEDEEKVSHQAGDHWLIRGPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLADRGEKDTAKSLQPLAPRNKTRVVSYRVPHNAAVQVYDYREKRARVVFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFEVNDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGFETSEAKGPDGMALPRPRDQAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPINLFNTAFGLLGMGPEGQPLGRRVASGPSPGEGISPQSAQAPQAPGDNHVVPVLR
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 6xHis-SUMO-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Tris-based buffer,50% glycerol
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
  • 基因功能參考文獻：
    1. KPNA7 binding and nuclear transfer was validated for two proteins, MVP and ZNF414. MVP and ZNF414 have a key role in the regulation of pancreatic cancer cell growth. PMID: 27664836
    2. Knockout of MVP leads to miR-193a accumulation in the exosomal donor cells instead of exosomes, inhibiting tumour progression. PMID: 28211508
    3. The expression levels of LRP and GSTP1 in primary epithelial ovarian cancer were the highest, followed by borderline adenoma tissues, and lowest levels in benign tumor tissues. The difference between resistant gene negative-expression and positive-expression of chemotherapy efficiency, disease free survival time, and recurrence time were statistically significant. PMID: 30313031
    4. KIF4A promotes drug resistance of lung adenocarcinoma cells through transporting LRP-based vaults along microtubules towards the cell membrane PMID: 29204984
    5. Major vault protein is important in the drug resistance of cancer cells, but it requires the presence of vPARP for full activity PMID: 28551640
    6. involved in doxorubicin resistance of non-small cell lung cancer PMID: 27817195
    7. Study found significant upregulation of MVP and BCRP whereas MRP1 and UGT1A4 were unaltered in drug resistant epilepsy brains. While upregulation of BCRP was significantly higher in mesial temporal lobe epilepsy (9.34+/-0.45; p<0.05), upregulation of MVP was significantly higher in focal cortical dysplasia (2.94+/-0.65; p<0.01). PMID: 28273590
    8. Taxus chinensis var.-mediated downregulation of MRP1, MDR1, and LRP might contribute to the reversal of drug resistance in non-small cell lung cancer stem cells. PMID: 27706681
    9. We believe that for the first time, genetic variants at XRCC6 and MVP genes are associated with risk of more aggressive disease, and would be taken into account when assessing the malignancy of prostate cancer PMID: 26754263
    10. MVP genetic polymorphisms and haplotypes may not be associated with drug resistance of partial epilepsy in the Chinese Han population. PMID: 26476776
    11. NSCLCs [ non-small cell lung cancer ] expressing P-gp [P-glycoprotein ]/LRP [ lung resistance-related protein] bear the EGFR [epidermal growth factor receptor] mutation in exon 19 or 21 easily. PMID: 26632382
    12. The association of MVP amplification and PTEN deletion could be a potential biomarker in glioblastoma. PMID: 25869624
    13. Bag3-MVP is an important complex that regulates a potent prosurvival signaling pathway and contributes to chemotherapy resistance in breast cancer PMID: 24997994
    14. LDL increases ABCB1, ABCC1, and LRP expression in a human doxorubicin-resistant uterine sarcoma cell line. PMID: 25603048
    15. Study demonstrates that vaults have a tumour-promoting potential by stabilizing EGFR/PI3K-mediated migration and survival pathways in human glioblastoma. PMID: 24243798
    16. USF1 binding to an E-box element may be critical for basal MVP promoter activation. PMID: 24173679
    17. hyperosmotic stress upregulates Sp1 expression levels by inhibiting ubiquitination through the activation of JNK, and the induction of Sp1 expression directly enhances MVP transcription. PMID: 23820674
    18. the protein levels of MVP, TEP1 and vPARP are actually increased in the highergrade tumors suggesting existence of post-transcriptional regulation of vault component production. PMID: 23739867
    19. Lung resistance-related protein is associated with malignant ascitic cells and recurrence in ovarian serous carcinoma. PMID: 23525731
    20. The phosphorylation-dependent binding between 14-3-3epsilon and MVP inhibits the drug-resistant activity of MVP. PMID: 23590642
    21. rs4788187, rs3815824, rs3815823 variants of the MVP gene are associated neither with predisposition for epilepsy nor with AED-resistance in the population that we have studied. PMID: 23751308
    22. MVP and IGF-1R expression are related in oral squamous cell carcinoma and conferred reduced long-term survival in patients suffering from advanced stages of the disease PMID: 22931894
    23. TRAIL may reduce the expression of drug-resistant genes MDR1, LRP and GST-pi, thereby participating in the reversion of the multidrug resistance of gastric cancer. PMID: 23178631
    24. GSTP1 and LRP have different effects on multi-drug resistance in adult acute leukemia. PMID: 22391170
    25. results suggest that the high expression of LRP in patients with tongue carcinoma indicates that intrinsic drug resistance may exist in tongue carcinoma, and is associated with tumor differentiation and cisplatin resistance in tongue carcinoma. PMID: 21793937
    26. These findings suggest MVP as a novel player in resistance against EGFR inhibition. PMID: 22261339
    27. MVP (major vault protein) expression increases dramatically in tissue samples from the frontal cortex of patients with surgically treated refractory epilepsy patients compared to histologically normal frontal lobe samples from controls. PMID: 21683962
    28. LRP and MRP play a role in multidrug resistance in non-small cell lung cancer (NSCLC) and are related to prognosis in patients with NSCLC PMID: 22117969
    29. Histopathology demonstrated increased amount of MVP/LRP proteins in cancer and showed translocation possibility between cytoplasm and nuclear envelope, which can be crucial in the prevention of nucleus against anticancer drugs. [review] PMID: 22235652
    30. MVP is hijacked by L. monocytogenes in order to counteract the autophagy process, a finding that could have major implications in deciphering the cellular role of vault particles. PMID: 21829365
    31. Loss of p53-related suppression of lung resistance-related protein through Y-box binding protein 1 may be the reason for LRP expression increase, and, therefore, chemotherapy resistance in tumor cells. PMID: 21344396
    32. The nasopharyngeal carcinoma patients with positive LRP and TS expression may be less sensitive to chemotherapy with DDP + 5-FU. PMID: 15952572
    33. Patients expressing both lung resistance protein and multidrug resistance-related protein genes had poorer outcomes and had worse 2-year survivalts. PMID: 19969624
    34. mRNA expression predicts chemotherapy response and survival in patients with non-small cell lung cancer who received neoadjuvant cisplatin-based chemotherapy PMID: 19875192
    35. P-gp and LRP expressions but not MRP expression are important in the mechanism of drug resistance associated with a poor clinical outcome in previously untreated non-Hodgkin's lymphoma. PMID: 19615260
    36. Data show that major vault protein (MVP), a lung resistance associated protein, is a binding partner of YPEL4. PMID: 20555386
    37. The expression of EGFR and LRP could be used to predict chemotherapy resistance and prognosis of ovarian cancer. PMID: 19080004
    38. findings suggest that Tax-related drug resistance of ATL cells is due to LRP and not MDR1, as reported previously. PMID: 11937269
    39. relationship between the expression of lung resistance-related protein (lrp) gene or multidrug resistance-associated protein (mrp) gene and prognosis in untreated acute leukemia (AL) patients PMID: 11940320
    40. LRP/MVP mRNA expression decreased as AML disease evolved, suggesting it is not associated with clinical resistant disease in AML. PMID: 11986944
    41. identification as a dominant PTEN-binding protein in a yeast two-hybrid screen PMID: 12177006
    42. RNA expression of this protein in breast cancer correlates with response to chemotherapy. PMID: 12576456
    43. expression of lung resistance-related protein in differentiated cells and subsequent expression after chemotherapy suggests that it plays a role in therapy-induced differentiation PMID: 12612883
    44. neither the presence nor the degree of immunoreactivity to MVP/LRP showed any correlation with either tumor grade or the presence of brain invasion PMID: 12622134
    45. In gangliogliomas, western blot analysis showed a consistent increase in major vault protein expression compared with control cortex. PMID: 12919388
    46. MVP and BCRP were expressed ubiquitously in brain capillary endothelium. Ectopic upregulation of MVP was seen in hilar neurons in HS, dysplastic neurons in FCD, and lesional neurons in DNT. Only in HS cases were rare extralesional neurons immunoreactive. PMID: 14636345
    47. Results suggest that major vault protein functions as a novel scaffold protein for both SHP-2 and Erk. PMID: 15133037
    48. The inverted MED1 element and the LRP130 protein have a role in transcription of the MVP gene. PMID: 15272088
    49. Expression of LRP tended to be down-regulated in carcinomas. Moreover, the expression of LRP inversely correlated with tumor grades. PMID: 15379935
    50. Vaults play no direct role in the multiple drug resistance phenotype in non-small cell lung carcinoma cells; their cellular function remains unknown. PMID: 15709737

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  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus, nuclear pore complex. Cytoplasm, perinuclear region. Note=5% found in the nuclear pore complex (PubMed:15133037). Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665).
  • 組織特異性：
    Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many mu
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7531

    OMIM: 605088

    KEGG: hsa:9961

    STRING: 9606.ENSP00000349977

    UniGene: Hs.632177