Recombinant Drosophila melanogaster Tyrosine-protein kinase hopscotch (hop), partial
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中文名稱(chēng):Recombinant Drosophila melanogaster Tyrosine-protein kinase hopscotch (hop), partial
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貨號(hào):CSB-EP631547DLU
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規(guī)格:¥2328
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圖片:
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其他:
產(chǎn)品詳情
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純度:Greater than 90% as determined by SDS-PAGE.
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生物活性:Not Test
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基因名:hop
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Uniprot No.:
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別名:HD-160;CG1594
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種屬:Drosophila melanogaster (Fruit fly)
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蛋白長(zhǎng)度:Partial
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來(lái)源:E.coli
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分子量:37.6 kDa
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表達(dá)區(qū)域:582-843aa
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氨基酸序列YPDSISLSDDGMMFTMRGDWIQQSPVKDVSVTMKMLKSDGNFMEFFRLAQTWSLIQSPQFLKLYGLTLADPYTMVMEYSRYGPLNKFLHSMPNVTLHCLLDLMHGLVRGMHYLEDNKIIHNYIRCSNLYVTKYDPNSYVLDAKISDPGYPRPYRESDSPWIPVKYYRNLQAAKTDQFAQLWAFATTIYEIFSRCKEDLSTLRQEQLLRQKNLDGNILKMLDQDICPAPIFETIMDGWSDDETKRFSHHDIFSRLNTIKAEIL
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request. -
蛋白標(biāo)簽:C-terminal 6xHis-tagged
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產(chǎn)品提供形式:Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
緩沖液:If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
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復(fù)溶:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲(chǔ)存條件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質(zhì)期:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期:Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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注意事項(xiàng):Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
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Datasheet & COA:Please contact us to get it.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Tyrosine kinase of the non-receptor type, phosphorylates the marelle protein. Required maternally for the establishment of the normal array of embryonic segments: involved in the control of pair-rule gene transcription in a stripe-specific manner. Together with Hsp83 and piwi, mediates canalization, also known as developmental robustness, likely via epigenetic silencing of existing genetic variants and suppression of transposon-induced new genetic variation.
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基因功能參考文獻(xiàn):
- dIAP1 and Cyclin A have been identified as two critical genes regulated by JAK/STAT and contributing to the growth of the Hedgehog-expressing cell population in Drosophila wing morphogenesis. PMID: 28045022
- Cell fusion during wound healing in Drosophila larval epidermis occurred primarily in the wound vicinity, where JAK/STAT activation was suppressed by fusion-inducing JNK signaling. PMID: 28424232
- These results illustrate a novel pro-tumourigenic crosstalk between the p38 MAPK pathway and JAK signalling in a Drosophila model of Myeloproliferative neoplasms. PMID: 28237966
- Data show that JNK signalling inhibits the growth of losers, while JAK/STAT signalling promotes competition-induced winner cell proliferation. PMID: 28743877
- Our study shows that haemocytes express the three upd genes and that injury markedly induces the expression of upd3 by the JNK pathway in haemocytes, which in turn activates the JAK/STAT pathway in the fat body and the gut. Surprisingly, release of Upd3 from haemocytes upon injury can remotely stimulate stem cell proliferation and the expression of Drosomycin-like genes in the intestine. PMID: 27231872
- Hop is a critical component of the piRNA pathway and that it maintains genome integrity by silencing transposons. PMID: 28193840
- these data led us to propose that Wdp acts as a novel negative feedback regulator of the JAK/STAT pathway in regulating intestinal homeostasis PMID: 25923769
- Our work indicates that Slit-Robo signaling affects stem cell function downstream of the JAK-STAT pathway by controlling the ability of stem cells to compete for occupancy in their niche. PMID: 25375180
- JAK/STAT signaling is critical for hinge fate specification and growth of the gap domain and that its restriction to the hinge is required for proper wing development PMID: 23978534
- Molecular components of JAK/STAT signaling pathway and its connection with transcription machinery PMID: 23888769
- Activation of JAK/STAT signaling pathway in S2 Drosophila melanogaster cell culture PMID: 23888780
- A functional link between cell polarity, the JAK/STAT signalling pathway and the Src kinases has been established in a whole organism. PMID: 23462467
- dUTX antagonizes JAK-STAT signaling to maintain proper gene expression and architecture of the Drosophila testis niche. PMID: 23364332
- Jak-STAT signaling from the hub acts on both GSCs and CySC to regulate their development and differentiation, and that additional signaling from CySCs to the GSCs play a dominant role in controlling GSC maintenance during niche formation. PMID: 23010510
- Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut. PMID: 23172913
- Studies identify miR-279 as a component of a feedback pathway that further dampens the response in cells with low levels of JAK/STAT activity. PMID: 21857668
- the JAK/STAT pathway is necessary and sufficient for optic lobe neuroepithelial growth. PMID: 21651897
- Data suggest that ISC self-renewal is cooperatively controlled by EGFR, Wg and JAK/STAT signaling pathway activities. PMID: 21440535
- not only is Upd specifically required in the mushroom bodies for olfactory aversive long-term memory but the Upd receptor Dome, as well as the Drosophila JAK and STAT homologs Hop and Stat92E, are also required PMID: 21518857
- Data show that isolated plasmatocytes can be triggered to differentiate into lamellocytes in vitro, either in response to Chn over-expression, or following activation of the JAK/STAT pathway. PMID: 21124962
- Dome signals both from the plasma membrane and internalised vesicles and show, using knockdown experiments, that endocytic components negatively regulate JAK-STAT signalling in vivo PMID: 20841381
- identified eye transformer as a novel negative regulator of the Drosophila JAK/STAT pathway both in vitro and in vivo PMID: 20624926
- Listericin gene encodes a novel antibacterial peptide-like protein whose induction is cooperatively regulated by PGRP-LE and the JAK-STAT pathway. PMID: 20348097
- These data suggest that a single JAK/STAT signal from the niche orchestrate the competitive and dependent co-existence of GSCs and CPCs in the Drosophila testis niche. PMID: 20143337
- JAK/STAT pathway functions cooperatively and in parallel with Wg signaling to control intestinal stem cells self-renewal. PMID: 19797317
- activated by unpaired to specify self-renewal and continual maintenance of the germ line stem cell population PMID: 11752574
- Upd in testis hub cells activates the JAK-STAT pathway in adjacent stem cells PMID: 11752575
- By clonal analysis for Stat92E and hop (Drosophila JAK) mutants we find that the JAK/STAT pathway is required in border cells for their migration PMID: 11804783
- requires the raf pathway to promote blood cell activation and differentiation PMID: 11919715
- The difference in effect between localized expression of ligand (Unpaired) and dominant active JAK (Hopscotch) demonstrates that the ligand plays a cell non-autonomous role in hindgut cell rearrangement. PMID: 12441298
- Four key components of the JAK/STAT pathway have been identified: Unpaired, a secreted ligand; Domeless, a cytokine-like receptor; Hopscotch, a JAK kinase; and Stat92E, a STAT transcription factor PMID: 14668372
- A genetic analysis was made of Hop to larval hemocyte concentration and the egg encapsulation response. PMID: 15082553
- dHop binds Hsp70 and Hsp90 and can rescue the growth defect in yeast. PMID: 15632128
- Accumulation of STAT protein and nuclear accumulation are positively regulated by JAK/STAT activity. PMID: 16000386
- hop signalling controls cell motility during germ cell migration. PMID: 16477645
- Study shows that although STAT directly regulates Sxl establishment promoter (SxlPe), it is dispensable for promoter activation; instead, JAK/STAT is needed to maintain high-level SxlPe expression in order to ensure Sxl autoregulation in XX embryos. PMID: 17363251
- main function of the JAK/STAT pathway in leg and antennal development is to promote the formation of a single proximo-distal axis per disc by constraining the intersection of wingless and decapentaplegic to the center of the disc. PMID: 17626283
- The JAK/STAT pathway functions downstream/independently of cap cell formation induced by Notch signaling. JAK/STAT signaling may also regulate dpp expression in the male GSC niche, suggesting a common origin of female and male GSC niches. PMID: 18283115
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亞細(xì)胞定位:Endomembrane system; Peripheral membrane protein.
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蛋白家族:Protein kinase superfamily, Tyr protein kinase family, JAK subfamily
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