sep-1 Antibody
-
中文名稱:sep-1兔多克隆抗體
-
貨號:CSB-PA271022XA01CXY
-
規(guī)格:¥440
-
促銷:
-
圖片:
-
其他:
產(chǎn)品詳情
-
產(chǎn)品名稱:Rabbit anti-Caenorhabditis elegans sep-1 Polyclonal antibody
-
Uniprot No.:
-
基因名:sep-1
-
別名:Separin homolog sep-1 (EC 3.4.22.49) (Separase) sep-1 Y47G6A.12
-
宿主:Rabbit
-
反應(yīng)種屬:Caenorhabditis elegans
-
免疫原:Recombinant Caenorhabditis elegans sep-1 protein (160-215aa)
-
免疫原種屬:Caenorhabditis elegans
-
標記方式:Non-conjugated
-
克隆類型:Polyclonal
-
抗體亞型:IgG
-
純化方式:>95%, Protein G purified
-
濃度:It differs from different batches. Please contact us to confirm it.
-
保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式:Liquid
-
應(yīng)用范圍:ELISA, WB
-
推薦稀釋比:
Application Recommended Dilution WB 1:500-1:5000 -
Protocols:
-
儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
靶點詳情
-
功能:Cysteine protease, which plays a central role in homologous chromosome separation during meiosis I and in sister chromatid separation during embryonic mitosis. Promotes chromosome/sister chromatid segregation by cleaving the scc-1 (mitosis) and rec-8 (meiosis) subunits of the cohesin complex at the onset of anaphase. May cleave histone H3-like protein cpar-1 during meiosis I metaphase-anaphase transition. Promotes cortical granule exocytosis after oocyte fertilization during the first meiotic anaphase. Essential for embryonic cytokinesis by regulating rab-11-positive vesicle trafficking at the plasma membrane at the cleavage furrow and midbody. Regulates centriole segregation during spermatocyte meiosis. Required for embryonic anterior-posterior axis formation.
-
基因功能參考文獻:
- Data indicate that protein phosphatase 5 is an important regulator of separase. PMID: 29246899
- These findings suggest that separase cleaves an unknown substrate to promote the exocytosis of RAB-11 vesicles and paves the way for biochemical identification of substrates. PMID: 28820333
- single-particle cryo-electron microscopy (cryo-EM) was used to determine a near-atomic-resolution structure of the Caenorhabditis elegans separase-securin complex. PMID: 28263324
- Examination of the N-terminal tail sequence of CPAR-1 revealed a putative separase cleavage site and mutation of the signature residues in this site eliminated the cleavage reaction. PMID: 25919583
- separase is required for cytokinesis by regulating the incorporation of RAB-11-positive vesicles into the plasma membrane at the cleavage furrow and midbody PMID: 20116245
- SEP-1 has two separable yet coordinated functions: to regulate cortical granule exocytosis and to mediate chromosome separation PMID: 17913784
顯示更多
收起更多
-
亞細胞定位:Cytoplasm. Chromosome. Cytoplasmic granule. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody.
-
組織特異性:Expressed in oocytes. Expressed in male germline. Expressed in spermatocytes but undetectable in spermatids (at protein level).
-
數(shù)據(jù)庫鏈接:
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-