TRHR Antibody
-
中文名稱:TRHR兔多克隆抗體
-
貨號:CSB-PA060009
-
規(guī)格:¥880
-
其他:
產(chǎn)品詳情
-
Uniprot No.:
-
基因名:
-
別名:TRHR; Thyrotropin-releasing hormone receptor; TRH-R; Thyroliberin receptor
-
宿主:Rabbit
-
反應(yīng)種屬:Human,Mouse,Rat,Monkey
-
免疫原:Synthesized peptide derived from the Internal region of Human TRH-R1.
-
免疫原種屬:Homo sapiens (Human)
-
標(biāo)記方式:Non-conjugated
-
抗體亞型:IgG
-
純化方式:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-
濃度:It differs from different batches. Please contact us to confirm it.
-
保存緩沖液:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
-
產(chǎn)品提供形式:Liquid
-
應(yīng)用范圍:WB, IF, ELISA
-
推薦稀釋比:
Application Recommended Dilution WB 1:500-1:2000 IF 1:200-1:1000 ELISA 1:20000 -
Protocols:
-
儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
-
功能:Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.
-
基因功能參考文獻(xiàn):
- These results demonstrate for the first time that not only agonist binding but also abundance of some signaling proteins may strongly affect TRH receptor dynamics in the plasma membrane PMID: 29137494
- a unique missense TRHR defect identified in a consanguineous family is associated with central hypothyroidism in homozygotes and hyperthyrotropinemia in heterozygotes, suggesting compensatory elevation of TSH with reduced biopotency; the I131T mutation decreases TRH binding and TRHR-Gq coupling and signaling PMID: 28419241
- rs16892496 polymorphism in the TRHR gene may play a role in FFM variation. PMID: 23543262
- The precoupling of receptors with their cognate G-proteins can contribute to faster G-protein activation and subsequent signal transfer into the cell interior. PMID: 22240728
- Data show that interactions of TRHR with GRKs and phosphatases are determined not simply by the amino acid sequences of the substrates, but by regions outside the cytoplasmic tails. PMID: 20345371
- A mutation in thyrotropin-releasing hormone receptor almost completely prevented receptor phosphorylation. PMID: 19906838
- TRH receptor in adenoma cells plays an important role in the paradoxical GH response to TRH administration in GH cell adenomas. PMID: 14599121
- after agonist-driven receptor internalization, the plasma membrane is replenished with younger receptors, arising either from an intracellular pool or preferential recycling of younger receptors. PMID: 15117874
- Controlled dimerization of the TRH receptor potentiates hormone-induced receptor trafficking. PMID: 16020481
- TRHR gene is an important gene for LBM variation. PMID: 19268274
- analysis of the effect of subcellular trafficking of the TRH receptor PMID: 19541745
顯示更多
收起更多
-
亞細(xì)胞定位:Cell membrane; Multi-pass membrane protein.
-
蛋白家族:G-protein coupled receptor 1 family
-
數(shù)據(jù)庫鏈接:
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-