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  • 中文名稱(chēng):
    TIFA兔多克隆抗體
  • 貨號(hào):
    CSB-PA839301LA01HU
  • 規(guī)格:
    ¥440
  • 促銷(xiāo):
    小規(guī)格抗體限時(shí)一口價(jià)
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng):
    Rabbit anti-Homo sapiens (Human) TIFA Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    TIFA
  • 別名:
    Putative MAPK activating protein PM14 antibody; Putative MAPK-activating protein PM14 antibody; Putative NF kappa B activating protein 20 antibody; Putative NF-kappa-B-activating protein 20 antibody; T2BP antibody; TIFA antibody; TIFA_HUMAN antibody; TRAF interacting protein with FHA domain containing protein A antibody; TRAF-interacting protein with FHA domain-containing protein A antibody; TRAF2 binding protein antibody; TRAF2-binding protein antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human TRAF-interacting protein with FHA domain-containing protein A protein (1-184AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated

    本頁(yè)面中的產(chǎn)品,TIFA Antibody (CSB-PA839301LA01HU),的標(biāo)記方式是Non-conjugated。對(duì)于TIFA Antibody,我們還提供其他標(biāo)記。見(jiàn)下表:

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱(chēng) 應(yīng)用
    HRP CSB-PA839301LB01HU TIFA Antibody, HRP conjugated ELISA
    FITC CSB-PA839301LC01HU TIFA Antibody, FITC conjugated
    Biotin CSB-PA839301LD01HU TIFA Antibody, Biotin conjugated ELISA
  • 克隆類(lèi)型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

引用文獻(xiàn)

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Adapter molecule that plays a key role in the activation of proinflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism. TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria: ADP-Heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of proinflammatory NF-kappa-B signaling.
  • 基因功能參考文獻(xiàn):
    1. TIFA may serve as a biomarker in the prediction of lung adenocarcinoma. Furthermore, TIFA may modulate lung cancer cell survival and proliferation through regulating the synthesis of apoptosis-associated proteins. PMID: 29975933
    2. TIFA is a crucial mediator in the endothelial innate immune response by potentiating and amplifying NLRP3 inflammasome via augmenting signals 1 and 2 PMID: 27965388
    3. study revealed that host TIFA and H. pylori-derived heptose-1,7-bisphosphate are critical effectors of innate immune signaling that account for much of the inflammatory response to H. pylori in gastric epithelial cells PMID: 28811347
    4. These results define TIFA as a rheostat for intracellular bacterial replication, escalating the immune response to invasive Gram-negative bacteria that exploit the host cytosol for growth. PMID: 28514661
    5. we report that Aurora A is essential for phosphorylation of the TRAF-interacting protein TIFA PMID: 28069801
    6. This study reports the crystal structures of TIFA (residues 1-150, with the unstructured C-terminal tail truncated) and its complex with the N-terminal phosphothreonine9 peptide (residues 1-15). PMID: 26389808
    7. an innate immune signaling axis, mediated by phosphorylation-dependent oligomerization of the TRAF-interacting protein with forkhead-associated domain (TIFA) that is triggered by heptose-1,7-bisphosphate. PMID: 26068852
    8. identify a novel threonine phosphorylation site on TIFA and show that this phosphorylated threonine binds with the FHA domain of TIFA, leading to TIFA oligomerization and TIFA-mediated NF-kappaB activation PMID: 22566686
    9. TIFA induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism PMID: 15492226

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  • 亞細(xì)胞定位:
    Cytoplasm.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 19075

    OMIM: 609028

    KEGG: hsa:92610

    STRING: 9606.ENSP00000354911

    UniGene: Hs.310640