STEAP3 Antibody, FITC conjugated
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中文名稱(chēng):STEAP3兔多克隆抗體, FITC偶聯(lián)
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貨號(hào):CSB-PA717655LC01HU
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規(guī)格:¥880
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其他:
產(chǎn)品詳情
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產(chǎn)品名稱(chēng):Rabbit anti-Homo sapiens (Human) STEAP3 Polyclonal antibody
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Uniprot No.:
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基因名:
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別名:STEAP3; TSAP6; Metalloreductase STEAP3; Dudulin-2; Six-transmembrane epithelial antigen of prostate 3; Tumor suppressor-activated pathway protein 6; hTSAP6; pHyde; hpHyde
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宿主:Rabbit
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反應(yīng)種屬:Human
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免疫原:Recombinant Human Metalloreductase STEAP3 protein (1-207AA)
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:FITC
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克隆類(lèi)型:Polyclonal
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抗體亞型:IgG
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純化方式:>95%, Protein G purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式:Liquid
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儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.
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基因功能參考文獻(xiàn):
- In hepatocellular carcinoma (HCC), lower expression of the STEAP3 copper reductase and heavy Cu isotope enrichment have been reported for the tumor mass, relative to the surrounding tissue PMID: 28303916
- TSAP6 over expression is associated with poor survival in metastatic high-grade serous carcinoma. PMID: 27825812
- heterozygous STEAP3 mutations are relatively common in humans and that their deleterious effect in humans remains to be confirmed PMID: 26675350
- TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysis. PMID: 22624035
- findings indicate that STEAP3 maintains iron storage in human malignant cells and tumor proliferation under the hypoferric condition PMID: 21871451
- TSAP6 may augment Myt1 activity and act downstream to p53 to interface apoptosis and cell-cycle progression PMID: 12606722
- role for TSAP6 in the export of TCTP and indicate that this multipass membrane protein could have a general role in the regulation of vesicular trafficking and secretion. PMID: 15319436
- The crystal structure of the human Steap3 oxidoreductase domain in the absence and presence of NADPH was determined. PMID: 18495927
- Down-regulated expression of the TSAP6 protein in liver is associated with a transition from cirrhosis to hepatocellular carcinoma PMID: 19236508
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相關(guān)疾?。?/div>Anemia, hypochromic microcytic, with iron overload 2 (AHMIO2)亞細(xì)胞定位:Endosome membrane; Multi-pass membrane protein. Note=Localizes to vesicular-like structures at the plasma membrane and around the nucleus.蛋白家族:STEAP family組織特異性:Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma.數(shù)據(jù)庫(kù)鏈接:
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