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SLC4A7 Antibody

  • 中文名稱：
    SLC4A7兔多克隆抗體
  • 貨號：
    CSB-PA897593DSR2HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時(shí)一口價(jià)
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA897593DSR2HU at dilution of 1:100
    • Immunofluorescent analysis of 293 cells using CSB-PA897593DSR2HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SLC4A7 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SLC4A7
  • 別名：
    Bicarbonate transporter antibody; BT antibody; Electroneutral Na/HCO(3) cotransporter antibody; NBC2 antibody; NBC3 antibody; S4A7 antibody; S4A7_HUMAN antibody; SBC2 antibody; SLC4A6 antibody; Slc4a7 antibody; Sodium bicarbonate cotransporter 2 antibody; Sodium bicarbonate cotransporter 2b antibody; Sodium bicarbonate cotransporter 3 antibody; Solute carrier family 4 member 7 antibody; Solute carrier family 4 sodium bicarbonate cotransporter member 7 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Sodium bicarbonate cotransporter 3 protein (240-400AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity.
  • 基因功能參考文獻(xiàn)：
    1. rs3278 and rs3755652 stimulate an alternative transcription of the SLC4A7 gene, increasing the production of a defective transporter. PMID: 28087757
    2. the disease-associated T allele of a new hypertension risk variant rs820430 linked increased hypertension risk through higher SLC4A7 expression, and rs820430 functioned as an enhancer of SLC4A7 transcription by allele distinctively increased c-Fos transcription factor binding. PMID: 27784683
    3. this is the first work to demonstrate 3'UTR-mediated NBCn1 regulation, shows that p95HER2 regulates NBCn1 expression at multiple levels, and substantiates the central position of p95HER2-NBCn1 signaling in breast cancer. PMID: 27609814
    4. The finding of a genotypic influence on SLC4A7 expression and pHi regulation in vascular smooth muscle cells provides an insight into the molecular mechanism underlying the association of variation at the SLC4A7 locus with blood pressure PMID: 28087731
    5. Upregulation of NBCn1 during human breast carcinogenesis contributes to the characteristic acid distribution within human breast carcinomas. PMID: 24788003
    6. A meta-analysis of genome-wide association studies of blood pressure and hypertension in Chinese identified three new loci (CACNA1D, CYP21A2, and MED13L) and a newly discovered variant near SLC4A7. PMID: 25249183
    7. We demonstrate, for the first time, that 3 different pHi regulators responsible for acid extruding, i.e. NHE and NBC, and MCT, are functionally co-existed in cultured radial artery smooth muscle cells. PMID: 25241983
    8. The SLC4A7 variant rs4973768 is associated with breast cancer risk. PMID: 23117855
    9. Na(+),HCO(3)(-)-cotransport is a major determinant of pH(i) in breast cancer. PMID: 22907202
    10. Data show that DeltaNErbB2 expression elicited Na(+), HCO(3)(-) cotransporter NBCn1 upregulation, Ser(703)-phosphorylation of Na(+)/H(+) exchanger NHE1. PMID: 22120673
    11. The present study generated a series of chimeras of human NBCe1-A and human NBCn1-A (SLC4A7). Replacing the fourth extracellular loop (EL4) of human NBCe1-A with EL4 of NBCn1-A creates an electroneutral NBC. PMID: 21224233
    12. NBCn1 inhibition attenuated cathepsin release and had no net effect on viability of MCF7 cells. PMID: 20542029
    13. The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the bicarbonate salvage trransporter isoform 3 PMID: 12403779
    14. structural and functional study PMID: 14578046
    15. NBC3 and CAII interact to maximize the HCO(3)(-) transport rate. Although PKA decreased NBC3 transport activity, it did so independently of the NBC3/CAII interaction and did not involve phosphorylation of NBC3Ct. PMID: 14736710
    16. Results suggest that SLC4A7 allelic variants might alter dispositions and/or excretion of drugs and neurotransmitters in brain and periphery in ways that could contribute to differential vulnerabilities to addictions. PMID: 17624982

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  • 亞細(xì)胞定位：
    Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cell projection, stereocilium.
  • 蛋白家族：
    Anion exchanger (TC 2.A.31) family
  • 組織特異性：
    Highly expressed in testis and spleen. Also expressed in retina, colon, small intestine, ovary, thymus, prostate, muscle, heart and kidney. Isoform 1 is expressed in skeletal muscle and heart muscle.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11033

    OMIM: 603353

    KEGG: hsa:9497

    STRING: 9606.ENSP00000295736

    UniGene: Hs.250072