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SLC17A8 Antibody

  • 中文名稱：
    SLC17A8兔多克隆抗體
  • 貨號(hào)：
    CSB-PA107772
  • 規(guī)格：
    ￥1100
  • 圖片：
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human cerebella tissue and Human cerebrum tissue lysates, Primary antibody: CSB-PA107772(SLC17A8 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SLC17A8 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Solute carrier family 17 (vesicular glutamate transporter), member 8; DFNA25; VGLUT3
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthetic peptide of human SLC17A8
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
  • 基因功能參考文獻(xiàn)：
    1. Novel pathogenic splicing mutation in SLC17A8 gene identified in a family with hearing loss. PMID: 28647561
    2. A point mutation in VGLUT3 dramatically reduces its expression in synaptic terminals without altering its function. PMID: 28314816
    3. The results of this study identify VGLUT3 as an unexpected regulator of drug abuse. PMID: 26239290
    4. The results from our study suggest that the p.M206Nfs*4 mutation in the SLC17A8 gene is likely a pathogenic mutation that causes autosomal dominant non-syndromic hearing loss. PMID: 26797701
    5. The absence of VGLUT3 in transgenic mice leads to an up-regulation of the midbrain dopamine system and ameliorates motor dysfunction in a model of Parkinson's disease. PMID: 26558771
    6. human vesicular glutamate transporter 3 was cloned, shows 72% identity to both hVGLUT1 and hVGLUT2, and its expression in brain overlaps with hVGLUT1 and hVGLUT2 PMID: 12151341
    7. Docking and homology modeling explain the inhibition of VGLUT3. PMID: 17660252
    8. VGLUT3 immunoreactivity covered only a limited portion of the possible Glu-ergic pathways in the human fetal small intestine. PMID: 18498073
    9. SLC17A8 encodes vesicular glutamate transporter-3, VGLUT3 and its impairment has a role in nonsyndromic deafness DFNA25 and inner hair cell dysfunction PMID: 18674745

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  • 相關(guān)疾病：
    Deafness, autosomal dominant, 25 (DFNA25)
  • 亞細(xì)胞定位：
    Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.
  • 蛋白家族：
    Major facilitator superfamily, Sodium/anion cotransporter family, VGLUT subfamily
  • 組織特異性：
    Expressed in amygdala, cerebellum, hippocampus, medulla, spinal cord and thalamus.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 20151

    OMIM: 605583

    KEGG: hsa:246213

    STRING: 9606.ENSP00000316909

    UniGene: Hs.116871