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RYR2 Antibody

  • 中文名稱：
    RYR2兔多克隆抗體
  • 貨號(hào)：
    CSB-PA040283
  • 規(guī)格：
    ￥880
  • 圖片：
    • Western Blot analysis of HepG2-UV MOUSE-BRAIN AD293 PC-3 cells using RyR-2 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    ARVC2 antibody; ARVD2 antibody; Cardiac muscle ryanodine receptor antibody; Cardiac muscle ryanodine receptor-calcium release channel antibody; hRYR-2 antibody; ryanodine receptor 2 (cardiac) antibody; Ryanodine receptor 2 antibody; RyR antibody; RYR-2 antibody; RyR2 antibody; RYR2_HUMAN antibody; Type 2 ryanodine receptor antibody; VTSIP antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human RyR-2 around the non-phosphorylation site of S2808.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.
  • 基因功能參考文獻(xiàn)：
    1. We sought to identify genetic alterations in cardiac ion channels in patients with micro-ischemic disease. Genetic analysis with Sanger technology and posterior bioinformatic assessment identified two rare variations with potential pathogenic effects (RyR2_p.M4019T and SCN5A_p.H445D) in two individuals. PMID: 28086167
    2. Genetic analysis of the index case identified only one rare novel variant p.Ile11Ser (c.32T>G) in the RyR2 gene. Subsequent familial analysis identified segregation of the genetic variant with the disease. To our knowledge, there has been no previous case report of catecholaminergic polymorphic ventricular tachycardia associated to this missense variant. PMID: 27988446
    3. Our findings provided evidence that Indel polymorphism rs10692285 might contribute to sudden unexplained death (SUD) susceptibility through affecting the expression of RYR2, which suggest that abnormal ion channel activity is very likely to be the underlying mechanism of SUD. PMID: 27987400
    4. Five of the 19 patients (26.3%) had either a pathogenic variant or a likely pathogenic variant in MYBPC3 (n=1), MYH7 (n=1), RYR2 (n=2), or TNNT2 (n=1). All five variants were missense variants that have been reported previously in patients with channelopathies or cardiomyopathies PMID: 28202948
    5. RYR2 variants show possible pathogenic Fibrosis of the Cardiac Conduction system. PMID: 27005929
    6. The most common form of CPVT is due to autosomal dominant variants in the cardiac ryanodine receptor gene (RYR2). PMID: 27157848
    7. Common variants rs790899 and rs1891246 of RYR2 were significantly associated with HG and weight loss. PMID: 27663074
    8. The left atrium / right atrium expression ratio was significantly increased in Atrial fibrillation for ryanodine receptor 2 - gene related to calcium uptake and release, and located on the sarcoplasmic reticulum membrane. PMID: 27494721
    9. a direct interaction exists between RyR2 and CSQ2, is reported. PMID: 27609834
    10. In a national cohort of RyR2 mutation-positive CPVT patients, SCD, ASCD and syncope were presenting events in the majority of probands and also occurred in 36% of relatives identified through family screening. PMID: 28237968
    11. We identified a variant in the RYR2 gene (NM_001035) which involved a change of a glycine to an arginine in position155 of the gene product (c.463G > A, p.Gly155Arg, p.G155R). This RYR2 gene mutation is a novel rare genetic variant as it was not present in any of the international databases consulted. PMID: 28405885
    12. Data suggest that post-translational modifications (phosphorylation, oxidation, and nitrosylation) of RyR2 (ryanodine receptor 2) occur downstream of production of amyloid beta-peptides through ADRB2 (beta2-adrenergic receptor) Ca2+ signaling cascade that activates PKA (protein kinase A). PMID: 28476886
    13. The unique properties of the CaM-F142L mutation may provide novel clues on how to suppress excessive RyR2 Ca(2+) release by manipulating the CaM-RyR2 interaction. PMID: 27927985
    14. Cardiac adrenergic response and progression towards HF proceed unaltered in mice harboring the RyR2-S2808A mutation. Preventing RyR2-S2808 phosphorylation does not preclude a normal sympathetic response nor mitigates the pathophysiological consequences of MI. PMID: 28065668
    15. These results also suggest that altered cytosolic Ca(2+) activation of RyR2 represents a common defect of RyR2 mutations associated with catecholaminergic polymorphic ventricular tachycardia and atrial fibrillation, which could potentially be suppressed by carvedilol or (R)-carvedilol. PMID: 27733687
    16. Long-Term Prognosis of Catecholaminergic Polymorphic Ventricular Tachycardia Patients With Ryanodine Receptor (RYR2) Mutations. PMID: 27523319
    17. Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) Associated With Ryanodine Receptor (RyR2) Gene Mutations- Long-Term Prognosis After Initiation of Medical Treatment. PMID: 27452199
    18. Genotype may predict phenotype in catecholaminergic polymorphic ventricular tachycardia, including a higher risk of life-threatening cardiac events in subjects with variants in the C-terminus of ryanodine receptor-2 (RyR2). [review] PMID: 28084961
    19. RYR2 C2277R mutation is a cause of catecholaminergic polymorphic ventricular tachycardia in a family with high lethality in younger individuals. PMID: 25435091
    20. RYR2, PTDSS1 and AREG are autism susceptibility genes that are implicated in a Lebanese population-based study of copy number variations in this disease. PMID: 26742492
    21. although the EF-hand domain is not required for RyR2 activation by cytosolic Ca(2+), it plays an important role in luminal Ca(2+) activation and SOICR PMID: 26663082
    22. Half of the RYR2 mutations in catecholaminergic polymorphic ventricular tachycardia cohort were de novo, and most of the remaining mutations were inherited from mothers. PMID: 26114861
    23. A deletion of exon 3 of the RYR2 gene was found in a family with catecholaminergic polymorphic ventricular tachycardia. PMID: 25835811
    24. G357S_RyR2 mutation in the cardiac ryanodine receptor was identified in 179 family members with Catecholaminergic polymorphic ventricular tachycardia and in 6 Sudden cardiac death cases. PMID: 25814417
    25. We propose a mechanism in which RYR2 sequence variants result in aberrant stress-induced calcium release into the mitochondria of autonomic neurons, resulting in an increased risk to develop autonomic/functional disease such as cyclic vomiting syndrome. PMID: 25925909
    26. Our study identifies a significant role of RyR2 rs3766871 minor allele for increased susceptibility to VT/VF in a population of implanted with a cardioverter defibrillator patients with heart failure. PMID: 25773045
    27. How phosphorylation of RyR affects channel activity and whether proteins such as the FK-506 binding proteins (FKBP12 and FKBP12.6) are involved in heart failure PMID: 26009186
    28. induced Pluripotent Stem Cell-derived cardiomyocytes are useful for investigating the similarities/differences in the pathophysiological consequences of RyR2 versus CASQ2 mutations underlying Catecholaminergic polymorphic ventricular tachycardia. PMID: 26153920
    29. results support aberrant RyR2 regulation as the disease mechanism for CPVT associated with CaM mutations and shows that CaM mutations not associated with CPVT can also affect RyR2 PMID: 26309258
    30. The results of our pilot study suggest that the rs2819742 variant within the gene for the RYR2 receptor could be associated with statin-induced myalgia/myopathy in patients on low doses of common statins. PMID: 25753936
    31. Data showed RyR2 on two novel familial compound mutations, c.6224T>C and c.13781A>G, with the clinical presentation of idiopathic ventricular fibrillation. PMID: 24950728
    32. functional heterologous expression studies suggest that the RyR2(R420Q) behaves as an aberrant channel, as a loss- or gain-of-function mutation depending on cytosolic intracellular Ca(2+) concentration. PMID: 25440180
    33. Catecholaminergic polymorphic ventricular tachycardia (CPVT) initially diagnosed as idiopathic ventricular fibrillation: the importance of thorough diagnostic work-up and follow-up. PMID: 25456695
    34. In transgenic mice, CPVT-associated RyR2 impaired glucose homeostasis. Pancreatic islets had intracellular Ca2+ leak via oxidized and nitrosylated RyR2 channels, activated ER stress response, mitochondrial dysfunction, and decreased insulin release. PMID: 25844899
    35. RYR2 mutations are frequent (9% of ARVC/D probands) and are associated with a conventional phenotype of ARVC/D. PMID: 25041964
    36. Here the solution and crystal structures determined under near-physiological conditions, as well as a homology model of the human RyR2 N-terminal region, are presented. PMID: 25372681
    37. data shed new insights into the structure-function relationship of the NH2-terminal domains of RyR2 and the action of NH2-terminal disease mutations PMID: 25627681
    38. RYR2 exon 3 deletion is frequently associated with left ventricular non-compaction. PMID: 24394973
    39. analysis of arrhythmia mechanisms in a RyR2-linked CPVT mutation (RyR2-A4860G) that depresses channel activity PMID: 25775566
    40. The principal action of flecainide in CPVT is not via a direct interaction with RyR2. Suggest model of flecainide action in which Na(+)-dependent modulation of intracellular Ca(2+) handling attenuates RyR2 dysfunction in CPVT. PMID: 25648700
    41. Rotavirus mimics human RYR2 by producing VP6 protein having high degree of homology towards RYR2 and significant antigenicity with respect to myasthenia gravis associated HLA haplotypes. PMID: 24929545
    42. Mutations in genes encoding cardiac ryanodine receptor 2 (RyR2) have been identified in several patients and are recognized as causing the autosomal dominant and recessive forms of CPVT PMID: 24793461
    43. The S96A HRC mutation disrupts the Ca2+ -microdomain around the RyR2, as it alters the Ca2+ -dependent association of RyR2 and HRC. PMID: 24805197
    44. Suggest that miR-106b-25 cluster-mediated post-transcriptional regulation of RyR2 is a potential molecular mechanism involved in paroxysmal atrial fibrillation pathogenesis. PMID: 25389315
    45. Three novel RYR2 missense mutations have been described in a Kazakh idiopathic ventricular tachycardia study cohort. PMID: 24978818
    46. Calcium-dependent cardiomyopathy is exacerbated by genetic ablation of ryanodine receptor 2. PMID: 24445321
    47. dysregulation of RyR2-mediated Ca(2+) release via aberrant CaM(F90L)-RyR2 interaction is a potential mechanism that underlies familial IVF PMID: 25036739
    48. Previously reported plausible pathogenic missense polymorphism G1886S may not be an independent predisposition factor of sudden unexplained nocturnal death syndrome in the southern Chinese Han population. PMID: 24447446
    49. It mediates calcium release from intracellular calcium stores such as the ER into the cytoplasm.(review) PMID: 24285081
    50. Mutation in RyR2 gene causes diastolic leakage of calcium cytosol and diastolic depolarization of cell's membrane, triggering polymorphic ventricular tachycardia. PMID: 24147812

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  • 相關(guān)疾病：
    Arrhythmogenic right ventricular dysplasia, familial, 2 (ARVD2); Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy (CPVT1)
  • 亞細(xì)胞定位：
    Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Sarcoplasmic reticulum.
  • 蛋白家族：
    Ryanodine receptor (TC 1.A.3.1) family, RYR2 subfamily
  • 組織特異性：
    Detected in heart muscle (at protein level). Heart muscle, brain (cerebellum and hippocampus) and placenta.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 10484

    OMIM: 180902

    KEGG: hsa:6262

    STRING: 9606.ENSP00000355533

    UniGene: Hs.109514