Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RASA1 Antibody

RASA1 Antibody

  • 中文名稱：
    RASA1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA019346GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    CM AVM antibody; CMAVM antibody; DKFZp434N071 antibody; GAP antibody; GTPase activating protein antibody; GTPase-activating protein antibody; OTTHUMP00000222390 antibody; OTTHUMP00000222391 antibody; OTTHUMP00000222392 antibody; OTTHUMP00000222393 antibody; p120GAP antibody; p120RASGAP antibody; PKWS antibody; Ras GTPase-activating protein 1 antibody; RAS p21 protein activator (GTPase activating protein) 1 antibody; Ras p21 protein activator antibody; RASA antibody; RASA1 antibody; RASA1_HUMAN antibody; RasGAP antibody; Triphosphatase activating protein antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human RASA1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1.
  • 基因功能參考文獻(xiàn)：
    1. A somatic RASA1 mutation in addition to the germline RASA1 mutation, was detected within endothelial cells in capillary malformation-arteriovenous malformation. PMID: 29024832
    2. RASA1 variants are rarely found in children with sporadic capillary malformations of lower limbs without capillary malformation-arteriovenous malformation syndrome. PMID: 29110021
    3. RASA1 mutations are associated melanoma tumorigenesis. PMID: 26993606
    4. MicroRNA-21 reduces RASA1 expression in cervical cancer cell lines and promotes cervical cancer cell migration via RASA1. Furthermore, Ras-induced epithelial-mesenchymal transition contributes to miR-21/RASA1 axis promoting cervical cancer cell migration. PMID: 27101583
    5. These results and the extreme variable expressivity support the hypothesis that somatic "second hits" are required for the development of vascular anomalies associated with CM-AVM syndrome. In addition, the phenotypes of the affected individuals further clarify that lymphatic manifestations are also part of the phenotypic spectrum of RASA1-related disorders. PMID: 26969842
    6. results indicate that, mTOR, Bad, or Survivin are not required for p120 RasGAP fragment N to protect cells from cell death; conclude that downstream targets of Akt other than mTORC1, Bad, or survivin mediate fragment N-induced protection or that several Akt effectors can compensate for each other to induce the pro-survival fragment N-dependent responses PMID: 23826368
    7. The interaction between RASA1 and EPHB4 is an indication of the major cause of capillary malformation with arteriovenous malformation. PMID: 28687708
    8. Low RASA1 expression is associated with Triple-Negative Breast Cancer. PMID: 28108518
    9. QKI-5 stabilized RASA1 mRNA via directly binding to the QKI response element region of RASA1, which in turn prevented the activation of the Ras-MAPK signaling pathway, suppressed cellular proliferation and induced cell cycle arrest. PMID: 27767378
    10. Data show that patients with low level of Ras GTPase-activating protein 1 (RASA1) expression correlated with a significantly poorer survival compared to those with high level of RASA1 expression. PMID: 28179330
    11. Results show that oncogenic KRAS can activate Rho through miR-31-mediated regulation of RASA1 indicating miR-31 acts as a KRAS effector to modulate invasion and migration in pancreatic cancer. PMID: 26747707
    12. Data suggest that, in response to netrin-1/netrin receptor (DCC) signaling, p120RasGAP is recruited to growth cones and supports axon outgrowth; p120RasGAP Src homology 2 domains exhibit scaffolding properties sufficient to support axon outgrowth. PMID: 26710849
    13. Maternal and fetal capillary malformation-arteriovenous malformation due to a novel RASA1 mutation presenting with prenatal non-immune hydrops fetalis have been found. PMID: 26096958
    14. This is the second largest study on isolated, non-syndromic Port-wine stain; data suggest that GNAQ is the main genetic determinant in this condition. Moreover, isolated port-wine stains are distinct from capillary malformations seen in RASA1 disorders. PMID: 26192947
    15. Data showed that hypoxia regulated the expression of miR-182 and RASA1 to promote HCC angiogenesis. PMID: 26126858
    16. p120RasGAP shields Akt from deactivating phosphatases in FGF1 signaling, but loses this ability once cleaved by caspase-3. PMID: 26109071
    17. Capillary malformation-arteriovenous malformation syndrome (CM-AVM) is an autosomal dominant disorder caused by RASA1 mutations. PMID: 25040287
    18. Multifocal, small, round-to-oval, pinkish-to-red cutaneous capillary malformations are seen in more than 90% of people with RASA1 mutations. PMID: 23829194
    19. miR-21 promotes malignant behaviors of colon cancer cells by regulating RASA1 expression via RAS pathways. PMID: 25663768
    20. The individual contribution of each Akt isoform in p120 RasGAP fragment N-mediated cell protection against Fas ligand induced cell death, was investigated. PMID: 25246356
    21. Low RASA1 expression is associated with colorectal cancer. PMID: 25867276
    22. Results show that report that RasGAP associates to PDGFRbeta and prevents its direct activation. This underlying mechanism raises the possibility that PDGFRbeta-mediated diseases involve indirect activation of PDGFRbeta. PMID: 25733681
    23. RASA1 expression is associated with breast cancer progression and poor survival and diseasefree survival of patients. PMID: 25394563
    24. Antisense-mediated knockdown (anti-miR) revealed that miR-206/21 coordinately promote RAS-ERK signaling and the corresponding cell phenotypes by inhibiting translation of the pathway suppressors RASA1 and SPRED1. PMID: 25202123
    25. A ubiquitous binding partner of p190RhoGAP, p120RasGAP (RasGAP), is expressed in much lower levels in DKO4 cells compared to DLD1, and this expression is regulated by KRAS. PMID: 24465899
    26. The results of the present study indicate that P110, in combination with chemotherapeutics, is likely to represent a potential therapeutic strategy for cancer. PMID: 23447049
    27. The novel findings of this study shed light on the molecular mechanisms underlying the DLC1 inhibitory effects of p120 and suggest a functional cross-talk between Ras and Rho proteins at the level of regulatory proteins. PMID: 24443565
    28. RASA1 mutations specifically cause capillary malformation-arteriovenous malformation. PMID: 24038909
    29. These results indicate that stress-activated caspase-3 might contribute to the suppression of metastasis through the generation of fragment N2( RasGAP PMID: 24347041
    30. our study reveals mir-182 suppresses cell proliferation in vivo. RASA1 is related to cell apoptosis. We further show that mir-182 downregulates RASA1 PMID: 24600991
    31. RASA1 mutation is responsible for the aberrant lymphatic architecture and functional abnormalities, as visualized in the PKWS subject and in the animal model. PMID: 23650393
    32. MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA by repressing RAS p21 GTPase activating protein 1 (RASA1) PMID: 23322774
    33. 14-3-3 negatively regulates the RGC downstream of the PI3-kinase/Akt signaling pathway PMID: 23386617
    34. capillary malformation-arteriovenous malformation syndrome; study reports a family with a novel mutation in the RASA1 gene - a truncating mutation in exon 11 of RASA1 (Q503X) PMID: 23158644
    35. Ras and GTPase-activating protein (GAP) drive GTP into a precatalytic state as revealed by combining FTIR and biomolecular simulations PMID: 22949691
    36. multifocal capillary malformations is the key clinical finding to suggest a RASA1 mutation PMID: 22200646
    37. An update of the associated phenotype variability in a family with hereditary capillary malformations caused by a mutation in the RASA1 gene. PMID: 22342634
    38. arguments against G3BP1 being a genuine RasGAP-binding partner PMID: 22205990
    39. Cell adhesion to the substrate is necessary for RasGAP to bind Nck1. Cell detachment makes RasGAP incapable of associating with Nck1 and decreases RasGAP activity. PMID: 21664272
    40. The results assign an unexpected role for p120RasGAP in the regulation of integrin traffic in cancer cells and reveal a new concept of competitive binding of Rab GTPases and GAP proteins to receptors as a regulatory mechanism in trafficking. PMID: 21768288
    41. Nck1 activates RasGAP by direct binding in the substrate-attached but not in the suspended cells. PMID: 21664272
    42. An important role is revealed for p120 RasGAP (RASA1) as a transgenic regulator of CD4+CD8+ double-positive cell survival and positive selection in the thymus as well as naive T cell survival in the periphery. PMID: 21646295
    43. Ras mutation cooperates with beta-catenin activation to drive bladder tumourigenesis. PMID: 21368895
    44. A novel synonymous mutation (c.1229 G > A [p.K420K]) of RASA1 was identified in a Chinese population with sporadic Sturge-Weber syndrome PMID: 20821215
    45. Sema4D/Plexin-B1 promotes the dephosphorylation and activation of PTEN through the R-Ras GAP activity, inducing growth cone collapse. PMID: 20610402
    46. miR-132 acts as an angiogenic switch by suppressing endothelial p120RasGAP expression. PMID: 20676106
    47. In a collaborative study, 5 index patients (2 females, 3 males) with spinal AVMs or AVFs and cutaneous multifocal capillary lesions were investigated for the RASA1 gene mutation. PMID: 20007727
    48. We show a novel alternative pathway of apoptosis in human primary cells that is mediated by transcriptionally dependent decreases in p53 and c-Myc and decreases in p21. PMID: 11751853
    49. N-terminal fragment generated by caspase cleavage protects cells in a Ras/PI3K/Akt-dependent manner that does not rely on NFkappa B activation PMID: 11847220
    50. mutual regulation of Ras and NF1-GAP is essential for normal neuronal differentiation PMID: 12730209

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Capillary malformation-arteriovenous malformation (CMAVM); Parkes Weber syndrome (PKWS)
  • 亞細(xì)胞定位：
    Cytoplasm.
  • 組織特異性：
    In placental villi, detected only in the trophoblast layer (cytotrophoblast and syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9871

    OMIM: 139150

    KEGG: hsa:5921

    STRING: 9606.ENSP00000274376

    UniGene: Hs.664080