Rab 3A antibody; RAB 3A member RAS oncogene family antibody; Rab3a antibody; RAB3A member RAS oncogene family antibody; RAB3A_HUMAN antibody; RAS associated protein RAB 3A antibody; RAS associated protein RAB3A antibody; Ras related protein Rab 3A antibody; Ras related protein Rab3A antibody; Ras-related protein Rab-3A antibody
宿主:
Rabbit
反應(yīng)種屬:
Human
免疫原:
Recombinant Human Ras-related protein Rab-3A protein (1-220AA)
免疫原種屬:
Homo sapiens (Human)
標(biāo)記方式:
Biotin
克隆類型:
Polyclonal
抗體亞型:
IgG
純化方式:
>95%, Protein G purified
濃度:
It differs from different batches. Please contact us to confirm it.
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期:
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane. Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane. Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed. Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells. Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9. Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1. Plays also a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT. Interacts with MADD (via uDENN domain); the GTP-bound form is preferred for interaction.
基因功能參考文獻(xiàn):
Rab3A-22A blocks exocytosis at a stage downstream intra-acrosomal calcium release. PMID: 27613869
Rab3a accelerates cell proliferation by increasing cyclin D1 expression, enhances anti-cancer drug resistance, and increases tumorigenicity and self-renewal of glioma cells. PMID: 24965146
Data indicate that exocytic stimuli promote ADP ribosylation factor 6 (ARF6) activation, which accomplishes exocytosis by stimulating Rab3A GTP-Binding Protein. PMID: 25713146
Five compounds which possess good inhibitory activity and may act as potential high affinity inhibitors against Rab3A active site were identified PMID: 24652202
alpha-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity PMID: 23344955
Rab27 and Rab3 sequentially regulate human sperm dense-core granule exocytosis. PMID: 22753498
Myo5a and Rab3A are direct binding partners and interact on synaptic vesicles and the Myo5a/Rab3A complex is involved in transport of neuronal vesicles PMID: 21349835
Mutation screening of the RAB3A gene in 47 individuals with autism provided no evidence that DNA variants in this gene are associated with autism. PMID: 15005721
In conclusion, we have found no evidence for RAB3A conferring susceptibility on mental retardation in the Han Chinese population. PMID: 16584842
Initiates exocytosis in acrosome when prenylated and activated with guanosine triphosphate (GTP). PMID: 17625073
Rab3GEP has a role as the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes PMID: 18559336
Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis PMID: 19546222
The maturation of amyloid precursor protein (APP) transport vesicles, including recruitment of conventional kinesin, requires Rab3A GTPase activity. PMID: 19923287