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PGP Antibody, Biotin conjugated

  • 中文名稱：
    PGP兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA017873LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PGP Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PGP
  • 別名：
    PGP antibody; PGP_HUMAN antibody; PGPase antibody; Phosphoglycolate phosphatase antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Glycerol-3-phosphate phosphatase protein (140-300AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP.
  • 基因功能參考文獻(xiàn)：
    1. data explain how PGP exerts control over EGF-induced cellular protein tyrosine phosphorylation, and reveal an unexpected influence of triacylglycerol turnover on growth factor signaling. PMID: 29524543
    2. Phosphoglycolate phosphatase rescues central carbon metabolism from toxic secondary metabolites in humans and yeast. PMID: 27544441
    3. Data indicate that Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance (MDR) via utilization of lysosomal P-glycoprotein (Pgp) transport activity. PMID: 25720491
    4. acute myeloid leukemia patients with co-expression of PGP and Ly showed better overall survival compared with PGP(+) patients without Ly expression PMID: 21861206
    5. expressed in skin lesions from groins and axilla in patients with hidradenitis suppurativa PMID: 20091410
    6. The available data indicate that St. John's wort is a potent induced of CYP 3A4 and P-glycoprotein (PgP), although it may inhibit or induce other CYPs... See page 262. PMID: 15260917
    7. cerp-gp confers resistance to ceramide-induced apoptosis, with modulation of the ceramide-glucosylceramide pathway GCS making a marked contribution to this resistance PMID: 15661399
    8. the PI3K/Akt pathway is involved in MDR in lymphoma cell lines and PI3K/Akt inhibition correlates down-regulation of NF-kappaB activity and inhibition Pgp function. PMID: 18640717
    9. Observational study of gene-disease association. (HuGE Navigator) PMID: 16160620
    10. Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 17038883

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  • 蛋白家族：
    HAD-like hydrolase superfamily, CbbY/CbbZ/Gph/YieH family
  • 組織特異性：
    Detected in all tissues including red cells, lymphocytes and cultured fibroblasts (at protein level). The highest activities occur in skeletal muscle and cardiac muscle.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 8909

    OMIM: 172280

    KEGG: hsa:283871

    STRING: 9606.ENSP00000330918

    UniGene: Hs.442634