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PDHB Antibody

  • 中文名稱：
    PDHB兔多克隆抗體
  • 貨號：
    CSB-PA017717ESR2HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時一口價
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA017717ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA017717ESR2HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PDHB Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    DKFZp564K0164 antibody; mitochondrial antibody; ODPB_HUMAN antibody; pdhB antibody; PDHBD antibody; PDHE1 B antibody; PDHE1-B antibody; PHE1B antibody; Pyruvate dehydrogenase (lipoamide) beta antibody; Pyruvate dehydrogenase E1 beta polypeptide antibody; Pyruvate dehydrogenase E1 component subunit beta antibody; Pyruvate dehydrogenase E1 component subunit beta mitochondrial antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Pyruvate dehydrogenase E1 component subunit beta, mitochondrial protein (1-300AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
  • 基因功能參考文獻(xiàn)：
    1. PDHB was downregulated in nasopharyngeal carcinoma cells. Forced expression of PDHB in NPC cells inhibited cell growth and migration, while knocking down the expression of PDHB promoted the growth, migration, and tumorigenesis of NPC cells. PDHB inhibited ERK signaling and cell growth driven by RasV12. PMID: 26857147
    2. Data indicate that (pro)renin receptor ATP6PA2 interacts with the E1 beta subunit of pyruvate dehydrogenase and controlling its protein stability PMID: 25720494
    3. PHD3 depletion did not affect the expression of the PDH-E1alpha, E1beta, and E2 subunits, or the phosphorylation status of E1alpha, but destabilized the PDH complex (PDC), resulting in less functional PDC. PMID: 25088999
    4. Sequencing of PDHB reveals a homozygous point mutation (c.302T>C), causing a predicted amino acid change in patient 1. Patient 2 is compound heterozygote for mutations c.301A>G (p.M101V) and c.313G>A (p.R105Q). PMID: 19924563
    5. Data indicate that PDH deficiency in our patient involves a post-translational modification in which EGFR-PTK-mediated tyrosine phosphorylation of the E1beta protein leads to enhanced ubiquitination followed by proteasome-mediated degradation. PMID: 17923481
    6. clinical findings are similar to those of PDHA1 deficiency, except that ataxia was more frequent in PDHA1 cases and consanguinity was found only in PDHB families. PMID: 18164639
    7. Species specificity in the interaction between hE1beta and hE2 in pyruvate dehydrogenase complex. PMID: 18206651

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  • 相關(guān)疾病：
    Pyruvate dehydrogenase E1-beta deficiency (PDHBD)
  • 亞細(xì)胞定位：
    Mitochondrion matrix.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 8808

    OMIM: 179060

    KEGG: hsa:5162

    STRING: 9606.ENSP00000307241

    UniGene: Hs.161357