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NKD1 Antibody, Biotin conjugated

  • 中文名稱：
    NKD1兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA853369LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) NKD1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    NKD1 antibody; NKD antibody; PP7246 antibody; Protein naked cuticle homolog 1 antibody; Naked-1 antibody; hNkd antibody; hNkd1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Protein naked cuticle homolog 1 protein (269-384AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產品評價

靶點詳情

  • 功能：
    Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity.
  • 基因功能參考文獻：
    1. the downregulation of NKD1 may be involved in the proliferation and migration of osteosarcoma cells through the activation of the canonical Wnt signaling pathway. PMID: 29115501
    2. The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocellular carcinoma cells. PMID: 27231134
    3. HNF1A-AS1 promoted HCC cell proliferation by repressing the NKD1 and p21 expression. PMID: 28292020
    4. Data indicate that microRNA miR-744 activated Wnt/beta-catenin pathway by targeting multiple negative regulators of Wnt/beta-catenin signaling, including SFRP1, GSK3beta, TLE3 and NKD1, and that NKD1 is a major functional target of miR-744. PMID: 28107193
    5. NKD1 showed significantly increased level after induction chemotherapy achieved complete remission in follow-up paired acute myeloid leukemia patients ( p < 0.001). These findings indicated that reduced NKD1 expression is associated with unfavorable clinical outcome in cytogenetically normal acute myeloid leukemia. PMID: 28443469
    6. Low NKD1 expression is associated with hepatocellular carcinoma. PMID: 27507614
    7. Silencing of NKD1 significantly inhibited the proliferation and invasion of osteosarcoma cells. PMID: 28032380
    8. Suggest that NKD1 plays an important role in invasion in human breast cancer and it appears to be a potential prognostic marker for patients with breast cancer. PMID: 26097589
    9. Reduced NKD1 protein expression correlates with a poor prognosis in NSCLC PMID: 21599923
    10. Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling PMID: 19956716

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  • 亞細胞定位：
    Cell membrane. Cytoplasm.
  • 蛋白家族：
    NKD family
  • 組織特異性：
    Expressed in colon, heart, kidney, leukocyte, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine and spleen.
  • 數據庫鏈接：

    HGNC: 17045

    OMIM: 607851

    KEGG: hsa:85407

    STRING: 9606.ENSP00000268459

    UniGene: Hs.187578