MIP1 Antibody
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中文名稱:MIP1兔多克隆抗體
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貨號:CSB-PA322240XA01SVG
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規(guī)格:¥440
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促銷:
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圖片:
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其他:
產(chǎn)品詳情
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Uniprot No.:
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基因名:MIP1
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別名:DNA polymerase gamma (EC 2.7.7.7) (Mitochondrial DNA polymerase catalytic subunit) MIP1 YOR330C
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反應(yīng)種屬:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
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免疫原:Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) MIP1 protein (1-250aa )
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免疫原種屬:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
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標記方式:Non-conjugated
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克隆類型:Polyclonal
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抗體亞型:IgG
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純化方式:Protein G
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA, WB
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Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點詳情
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功能:Involved in the replication of mitochondrial DNA.
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基因功能參考文獻:
- Yeast Mip1, the mitochondrial DNA polymerase gamma, harbors a conserved C-terminal extension required for maintenance of mitochondrial DNA in vivo. PMID: 16491467
- Our study also further confirms the utility of yeast Mip1p as a tool for studying human DNA polymerase (pol gamma)variants. PMID: 26077851
- Disrupting exonuclease activity of mutant variants was not associated with increased spontaneous mutagenesis compared with exonuclease-proficient alleles, suggesting that most or all of the mtDNA was replicated by wild type Mip1. PMID: 25340760
- disruption of Mip1 exonuclease activity increases mtDNA deletions 160-fold. PMID: 23589460
- Point mutations in the 3'-5' exonuclease domain of Mip1 result in severe impairment of the polymerase function and DNA binding. PMID: 20601675
- mip1 containing mutations associated with mitochondrial disease causes mutagenesis and depletion of mtDNA in Saccharomyces cerevisiae. PMID: 20185557
- Mip1p contains a single nucleotide polymorphism changing the strictly conserved threonine 661 to alanine. This substitution is responsible for the increased rate of mitochondrial DNA point mutations and deletions in these strains. PMID: 17720904
- The yeast mitochondrial DNA (mtDNA) replicase Mip1 has been used as a model to generate five mutations equivalent to POLG mutations associated with a broad spectrum of diseases in human. PMID: 17980715
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亞細胞定位:Mitochondrion.
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蛋白家族:DNA polymerase type-A family
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數(shù)據(jù)庫鏈接:
KEGG: sce:YOR330C
STRING: 4932.YOR330C
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