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  4. MARK3 Antibody, FITC conjugated

MARK3 Antibody, FITC conjugated

  • 中文名稱：
    MARK3兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA013498LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) MARK3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    C-TAK1 antibody; Cdc25C associated protein kinase 1 antibody; Cdc25C-associated protein kinase 1 antibody; cTAK1 antibody; ELKL motif kinase 2 antibody; EMK-2 antibody; Emk2 antibody; ETK 1 antibody; KIAA4230 antibody; KP78 antibody; MAP microtubule affinity regulating kinase 3 antibody; MAP/microtubule affinity-regulating kinase 3 antibody; Mark3 antibody; MARK3_HUMAN antibody; Par 1a antibody; PAR1A antibody; Protein kinase STK10 antibody; Ser/Thr protein kinase PAR-1 antibody; Serine threonine protein kinase p78 antibody; Serine/threonine-protein kinase p78 antibody; SerThr protein kinase PAR 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human MAP/microtubule affinity-regulating kinase 3 protein (368-667AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1.
  • 基因功能參考文獻：
    1. Authors identified a regulatory switch controlled by MARK3 that couples microtubules to the actin cytoskeleton to establish epithelial cell polarity through ARHGEF2. PMID: 29089450
    2. findings indicate that brain PP-1I associates with and is regulated by the associated protein kinases C-TAK1 and PFTK1 PMID: 25028520
    3. We have shown that serum ALP levels modified the association of MARK3 with bone mineral density in osetoporosis for Chinese patients. PMID: 23894155
    4. interaction between Mitf and C-TAK1 was demonstrated. PMID: 20214879
    5. results show that LKB1 can direct the phosphorylation of the serine-threonine kinase PAR1A PMID: 12879020
    6. identify sequence motifs required for stable C-TAK1 association and substrate phosphorylation PMID: 12941695
    7. The C-TAK1/p78 constitutively associates with and phosphorylates KSR1 generating a 14-3-3 binding site. PMID: 15182702
    8. Data show that the protein kinase Cdc25 C-associated kinase 1 (C-TAK1) is a binding partner and a substrate of Pim-1, and suggest a role for Pim-1 as a positive regulator at the G(2)/M transition of the cell cycle. PMID: 15319445
    9. 14-3-3 binding to MARK3 is dependent on phosphorylation. PMID: 16968750
    10. Class IIa histone deacetylases (HDACs) are subjected to signal-independent nuclear export that relies on their constitutive phosphorylation. EMK and C-TAK1, are identified as regulators of this process. PMID: 16980613
    11. identify a molecular mechanism through which the hMARK3 UBA domain has evolved to bind the kinase domain PMID: 17726107
    12. occurrence of an unusual TG 3' splice site in intron 3 PMID: 17672918

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  • 亞細胞定位：
    Cell membrane; Peripheral membrane protein. Cell projection, dendrite. Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6897

    OMIM: 602678

    KEGG: hsa:4140

    STRING: 9606.ENSP00000411397

    UniGene: Hs.35828