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KLRK1 Antibody

  • 中文名稱：
    KLRK1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA012474LA01HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時(shí)一口價(jià)
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA012474LA01HU at dilution of 1:100
    • Immunofluorescent analysis of A549 cells using CSB-PA012474LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: A549 whole cell lysate, HepG2 whole cell lysate
      All lanes: KLRK1 antibody at 3.7µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 26 kDa
      Observed band size: 34 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：

    The KLRK1 polyclonal antibody is a type of antibody that recognizes and binds to the human KLRK1 protein. The KLRK1 protein, also known as NKG2D, mainly functions to recognize and binds to stress-induced ligands expressed on the surface of infected or transformed cells, which allows the immune system to detect and eliminate these cells. KLRK1-mediated cytotoxicity is important for the immune response against viral infections and cancer, as well as for the elimination of cells undergoing cellular stress, such as cells undergoing DNA damage or apoptosis.

    KLRK1 antibody is derived from multiple clones of B cells within the rabbit immunized with the recombinant human NKG2D protein (73-216aa), which produces a mixture of antibodies that can recognize different epitopes of the KLRK1 protein. The KLRK1 antibody underwent protein G affinity chromatography, getting a purity exceeding 95%. It has been quality validated in ELISA, WB, IHC, and IF applications.

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) KLRK1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    KLRK1; D12S2489E; NKG2D; NKG2-D type II integral membrane protein; Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor; CD antigen CD314
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human NKG2-D type II integral membrane protein (73-216AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，KLRK1 Antibody (CSB-PA012474LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于KLRK1 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA012474LB01HU KLRK1 Antibody, HRP conjugated ELISA
    FITC CSB-PA012474LC01HU KLRK1 Antibody, FITC conjugated
    Biotin CSB-PA012474LD01HU KLRK1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type II membrane protein. Note=Colocalized with HCST on the cell surface.
  • 組織特異性：
    Expressed in natural killer (NK) cells, CD8(+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs).
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 18788

    OMIM: 611817

    KEGG: hsa:100528032

    STRING: 9606.ENSP00000240618

    UniGene: Hs.387787