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KCNK16 Antibody, Biotin conjugated

  • 中文名稱：
    KCNK16兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA850434LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) KCNK16 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    KCNK16
  • 別名：
    KCNK16; TALK1; Potassium channel subfamily K member 16; 2P domain potassium channel Talk-1; TWIK-related alkaline pH-activated K(+ channel 1; TALK-1
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Potassium channel subfamily K member 16 protein (259-309AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.
  • 基因功能參考文獻：
    1. data establish TALK-1 channels as key regulators of beta cell ER Ca(2+) and suggest that TALK-1 may be a therapeutic target to reduce ER Ca(2+) handling defects in beta cells during the pathogenesis of diabetes. PMID: 28928238
    2. The TALK-1/iOPN complex caused Vm hyperpolarization and reduced beta-cell glucose-stimulated Ca2+ influx, which is predicted to inhibit glucose stimulated insulin secretion. PMID: 28403169
    3. These findings reveal TALK-1 channels as important modulators of second-phase insulin secretion and suggest a clinically relevant mechanism for rs1535500, which may increase type 2 diabetes risk by limiting glucose-stimulated insulin secretion. PMID: 26239056
    4. at least two functional TALK-1 variants are present and may serve as background K+ currents in certain cells of the human pancreas. PMID: 12724142
  • 亞細胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Two pore domain potassium channel (TC 1.A.1.8) family
  • 組織特異性：
    Highly expressed in pancreas. Not detectable in the other tissues tested.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14464

    OMIM: 607369

    KEGG: hsa:83795

    STRING: 9606.ENSP00000391498

    UniGene: Hs.287765