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  4. IL25 Antibody

IL25 Antibody

  • 中文名稱：
    IL25兔多克隆抗體
  • 貨號：
    CSB-PA875653ESR1HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時一口價
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA875653ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) IL25 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    IL 17E antibody; IL 25 antibody; IL-17E antibody; IL-25 antibody; IL17e antibody; IL25 antibody; IL25_HUMAN antibody; Interleukin 17E antibody; Interleukin 25 antibody; Interleukin-17E antibody; Interleukin-25 antibody; Interleukin17E antibody; Interleukin25 antibody; OTTHUMP00000027946 antibody; OTTHUMP00000246238 antibody; UNQ3120/PRO10272 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Interleukin-25 protein (33-177AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses.
  • 基因功能參考文獻：
    1. this review details the structural characteristics, expression patterns, responder cells, biological properties, and role of IL-25 in disease pathogenesis PMID: 30345318
    2. this study shows that IL-25 reduces Th17 cells and inflammatory responses in human peripheral blood mononuclear cells PMID: 29966691
    3. Endometrial stromal cells differentiate into decidual stromal cells in the presence of ovarian hormones, resulting in the upregulation of IL25/IL17RB expression in endometrial stromal cells. PMID: 29257317
    4. In conclusion, the findings of the present study suggest that IL-25 but not IL-33 might contribute to the pathogenesis of chronic eosinophilic inflammation of the lung in patients with CEP. PMID: 28875265
    5. Nasal Il-25 is overexpressed in patients with chronic rhinosinusitis with nasal polyps and airway hypersensitiveness. PMID: 28870448
    6. IL-25-induced activation of nasal fibroblast and its association with the remodeling of chronic rhinosinusitis with nasal polyposis PMID: 28771607
    7. The authors concluded that IL-25 provides protection from amebiasis, which is dependent upon intestinal eosinophils and suppression of TNF-alpha. PMID: 28246365
    8. Inhibition of IL-25 resulted in decreased type 2 T cells and macrophages in the primary tumor microenvironments, both reported to enhance breast tumor invasion and subsequent metastasis to the lung. PMID: 27909985
    9. Our findings suggest that the IL-25/IL-25R axis may play an important role in promoting the recruitment and proinflammatory function of eosinophils in allergic asthma. PMID: 27685606
    10. Chronic rhinosinusitis with nasal polyps (CRSwNP) epithelial cells release TSLP and IL-25 when stimulated by poly(I:C) but not by DP or AF, suggesting that viral infection may contribute to maintain and amplify the T2 immune response seen in CRSwNP. PMID: 28127565
    11. Increased induction and expression of TSLP, IL-25, and IL-33 from nasal epithelial cells contribute to the pathophysiology of eosinophilic chronic rhinosinusitis. PMID: 26540312
    12. Women with endometriosis showed significantly higher levels of IL-25 in their PF (p=0.019) compared to controls. IL-25 levels did not correlate with the stage of endometriosis. PMID: 26852387
    13. IL-8 and IL-25 are targets of miR-20b. PMID: 26845056
    14. Our findings indicate that the alarmin cytokines IL-33 and IL-25 increase basophil activation and migratory potential, and may pose as a novel therapeutic targets for the treatment of allergic asthma. PMID: 26762527
    15. The IL17E rs79877597 SNP was a modifier of the risk for psoriasis disease severity and psoriatic arthritis. PMID: 26347322
    16. Findings indicate that the release of interleukin 25 (IL-25) from tumour-associated fibroblasts (TAFs) may serve as a check point for control of mammary tumour metastasis. PMID: 27089063
    17. IL-25 upregulated PD-L1 surface expression through the signaling pathways of JNK and STAT3, with STAT3 found to constitutively occupy the proximal region of the PD-L1 promoter. PMID: 26321145
    18. we have demonstrated that the expression of ET-1 and IL-25 was coordinately upregulated in the lesional keratinocytes of patients with AD and a murine AD model. PMID: 25903653
    19. IL-25 overexpression was observed in eosinophilic chronic rhinosinusitis and may serve as a mediator of eosinophilic CRS. PMID: 25975248
    20. expression of immunoreactivity for IL-17A, IL-17RA, IL-17E, and IL-17F was significantly elevated in prostatic tissue from benign prostatic hyperplasia and prostate cancer compared with that in controls PMID: 26356122
    21. This article focuses on evidence for the role of IL-25, IL-33 and TSLP in human allergic disease; although this triad of cytokines is described as epithelial derived, it is clear that their expression within lung tissue is much more widespread.[Review] PMID: 25705788
    22. The levels of mRNA for IL-25 were not significantly elevated in parotid gland tissues from Kimura Disease patients as compared to controls. PMID: 25676453
    23. asthmatic epithelial cells have an increased intrinsic capacity for expression of a pro-type 2 cytokine in response to a viral infection, and IL-25 is a key mediator of RV-induced exacerbations of pulmonary inflammation PMID: 25273095
    24. increased levels in patients with chronic rhinosinusitis with nasal polyps PMID: 25704964
    25. Because IL-25 has a major role in triggering type 2 responses, bronchial epithelial IL-25 expression is likely a key determinant of type 2 response activation in asthma PMID: 25133876
    26. Human chorionic gonadotropin up-regulates Il25, promoting the proliferation of decidual stromal cells by activation of JNK and AKT signal pathways. PMID: 24746746
    27. Patients with the 'IL-5, IL-17A, IL-25-high' airway inflammatory pattern are often uncontrolled asthmatics, despite daily treatment. PMID: 23957336
    28. IL-25 and type 2 innate lymphoid cells have roles in development of pulmonary fibrosis PMID: 24344271
    29. IL-25 expression is markedly reduced during human and experimental fulminant hepatitis. PMID: 23564603
    30. IL-25 and IL-33-driven type-2 innate lymphoid cells have roles in atopic dermatitis PMID: 24323357
    31. IL-25 enhances herpes simplex virus (HSV)-1 and vaccinia virus replication by inhibiting filaggrin expression, and IL-25 acts synergistically with IL-4 and IL-13 to enhance HSV-1 replication in vitro PMID: 23657503
    32. Suggest that IL-25 production by airway epithelial cells is regulated by the transcription and protein release levels and that allergen proteases likely play pivotal roles in both biological processes. PMID: 23590308
    33. Our data demonstrate that IL-33 plays a critical role in the rapid induction of airway contraction by stimulating the prompt expansion of IL-13-producing type 2 innate lymphoid cells, whereas IL-25-induced responses are slower and less potent. PMID: 23810766
    34. IL-25 Is Decreased in Sera of Patients With inflammatory bowel disease. PMID: 23429464
    35. IL-25 secreted from epithelial cells has the potential to promote airway remodeling in asthma. PMID: 22691357
    36. We observed significant downregulation of IL-25 in women with recurrent miscarriage compared with controls. PMID: 22266274
    37. IL-25 production is differently regulated by TNF-alpha and TGF-beta1 in the human g PMID: 20944558
    38. production is linked to the amount of specific IgE antibodies in blood samples of 6 yr old children in Germany PMID: 20492545
    39. Findings suggest that IL-25 is elevated in asthma and contributes to angiogenesis. PMID: 21205894
    40. IL-25 may have a role in atopic dermatitis PMID: 20861853
    41. Eosinophils are the main source of IL-25, whereas activated CD4+ memory T cells are the IL-17RB-expressing cells in Churg-Strauss syndrome. PMID: 20729468
    42. IL-17A and IL-25 had opposing effects on thymic stromal lymphopoietin regulation in human nasal epithelial cells PMID: 19968632
    43. Overexpression of IL-17E up-regulates gene expression of Th2 cytokines and induces growth retardation, jaundice, and multiorgan inflammation in a transgenic mouse model. PMID: 11714825
    44. Transgenic overexpression from humans into mice results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production. PMID: 12239140
    45. IL-17E may contribute to the induction and maintenance of eosinophilic inflammation by acting on lung fibroblasts. This supports a role for IL-17E in asthma pathophysiology. PMID: 16522458
    46. IL-25 acts by amplifying TH2 cell-mediated allergic airway inflammation. IL-25 itself does not significantly induce allergic inflammation in vivo. PMID: 16950278
    47. IL-25 produced by innate effector eosinophils and basophils may augment the allergic inflammation by enhancing the maintenance and functions of TSLP-DC activated adaptive Th2 memory cells PMID: 17635955
    48. The upregulation of costimulation-induced IL-25 receptors and release of cytokines and chemokines from IL-25 treated costimulated Th cells were differentially regulated by intracellular JNK, p38 MAPK and NF-kappaB activity. PMID: 17719653
    49. Blocking IL-25 in an experimental model of allergic asthma prevents airway hyperresponsiveness, a critical feature of clinical asthma. PMID: 17889290
    50. Higher expressions of IL-17E, IL-17A, IL-17BR and IL-17R are associated with oral inflammation. PMID: 19095584

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    IL-17 family
  • 組織特異性：
    Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 13765

    OMIM: 605658

    KEGG: hsa:64806

    STRING: 9606.ENSP00000328111

    UniGene: Hs.302036