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  4. IL13RA2 Antibody

IL13RA2 Antibody

  • 中文名稱：
    IL13RA2兔多克隆抗體
  • 貨號(hào)：
    CSB-PA618901ESR1HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時(shí)一口價(jià)
  • 圖片：
    • Western blot
      All lanes: Interleukin-13 receptor subunit alpha-2 antibody at 5μg/ml + Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 44 kDa
      Observed band size: 44 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA618901ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) IL13RA2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Cancer/testis antigen 19 antibody; CD213a2 antibody; CT19 antibody; I13R2_HUMAN antibody; IL-13 receptor subunit alpha-2 antibody; IL-13R subunit alpha-2 antibody; IL-13R-alpha-2 antibody; IL-13RA2 antibody; IL13 receptor antibody; IL13BP antibody; IL13R antibody; Il13ra2 antibody; Interleukin 13 binding protein antibody; Interleukin 13 receptor alpha 2 chain antibody; Interleukin-13 receptor subunit alpha-2 antibody; Interleukin-13-binding protein antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Interleukin-13 receptor subunit alpha-2 protein (27-343AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:200-1:1000
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).
  • 基因功能參考文獻(xiàn)：
    1. this study shows that tricellulin is regulated via interleukin-13-receptor alpha2, affects macromolecule uptake, and is decreased in ulcerative colitis PMID: 28612843
    2. IL-13Ralpha2 alone induces invasiveness of human glioblastoma multiforme (GBM) cells without affecting their proliferation. In contrast, in the presence of the mutant EGFR (EGFRvIII), IL-13Ralpha2 promotes GBM cell proliferation in vitro and in vivo. PMID: 29203859
    3. The results showed that IL13Ralpha2 may be used as a marker of poorer prognosis in high-grade astrocytomas, even among tumors of the same grade. PMID: 28079349
    4. TMEM219 plays a critical role in Chi3l1-induced IL-13Ralpha2 mediated signalling and tissue responses. PMID: 27629921
    5. This study shows interleukin-13 receptor alpha 2 expression could be a useful prognostic marker for selecting patients with luminal breast cancer likely to follow a clinically aggressive course despite receiving systemic therapy. PMID: 29911489
    6. Transgenic expression of IL15 is an appealing strategy to enhance CAR T-cell effector function. We tested this approach in our IL13Ralpha2-positive glioma model in which limited IL13Ralpha2-CAR T-cell persistence results in recurrence of antigen-positive gliomas. T cells were genetically modified with retroviral vectors encoding IL13Ralpha2-CARs or IL15 (IL13Ralpha2-CAR.IL15 T cells). PMID: 28550091
    7. IL-13Ralpha2 may have a role in decreased overall survival in gastric cancer after gastrectomy PMID: 27351230
    8. cigarette smoke extracts activate the PKA, CREB, and IL-13Ralpha2 axis in lung endothelial cells. PMID: 27986643
    9. High expression of IL-13Ra2 is significantly associated with the growth and metastasis of glioma cells via the Scr/PI3K/Akt/mTOR pathway. PMID: 27623944
    10. Data indicate single-chain antibody (scFv47) as a highly selective interleukin 13 receptor subunit alpha 2 (IL13Ralpha2) targeting agent. PMID: 26656559
    11. IL13Ralpha2 knockdown and IL-13 treatment cooperatively upregulated the metastasis suppressor tumor protein 63 (TP63) in a STAT6-dependent manner. PMID: 26208975
    12. Expression of CXCR3 in fibroblasts is associated with the expression of IL-13Ralpha2. PMID: 25514189
    13. In this review, we will discuss the recent advances in the IL13Ralpha2-targeted immunotherapy and evaluate the most promising strategy for targeted GBM immunotherapy. [review] PMID: 25247196
    14. Study presents evidence that PNR could promote ERalpha-negative breast cancer metastasis through activation of IL-13Ralpha2-mediated signaling pathway. PMID: 24747967
    15. In cytotoxicity assays, CAR T cells killed CAR T cells killed IL13Ra1- and/or IL13Ra2-positive cells in contrast to IL13Ra1- and IL13Ra2-negative controls PMID: 24841514
    16. IL13Ralpha2 over-expression is associated with glioma. PMID: 24204956
    17. Expression of IL-13Ralpha2 in tumors was significantly decreased with IL-13-PE treatment as compared to the controls and the number of myeloid-derived suppressor cells (MDSC) was also significantly reduced in the spleens of the IL-13-PE treated mice PMID: 23421960
    18. high expression of IL-13Ralpha2 was associated with later stages of disease progression and poor outcome in patients with colorectal cancer PMID: 22505647
    19. IL-13RALPHA2 is involved in cancer metastasis through activation of ERK/AP-1 PMID: 21858811
    20. expression of IL-13Ralpha2 prevents apoptosis and contributes to tumor growth. PMID: 21596889
    21. A novel function of histone modification in the regulation of IL-13Ralpha2 in pancreatic cancer cell lines in vitro and in vivo, was identified. PMID: 21477288
    22. Cells with high IL-13Ralpha2 expression rapidly and efficiently deplete extracellular IL-13 and could have important implications for the design and characterization of IL-13 antagonists. PMID: 21622864
    23. IL-13Ralpha2 may be an important endogenous regulator of IL-13-induced cutaneous inflammation in humans. PMID: 20971924
    24. The expression level of IL-13Ralpha2 was significantly reduced in first-recurrent glioblastomas (frGBMs) compared to primary GBMs, and significantly reduced in all untreated malignant astrocytomas compared with treated frGBMs. PMID: 20805641
    25. In eosinophil lineage-deficient IL-13 transgenic mice with eosinophilic esophagitis, IL-13-induced remodeling is significantly enhanced by IL-13Ralpha2 deletion, indicating an inhibitory effect of IL-13Ralpha2. PMID: 20543112
    26. IL-13Ralpha2-positive tumors were targeted by IL-13PE cytotoxin in vitro and in vivo in an orthotopic murine model of human pancreatic cancer. PMID: 20068108
    27. Soluble IL-13R2alpha and membrane IL-13R2alpha isoforms are both derived from the membrane form of the human receptor. An alternatively spliced sIL-13R2alpha transcript is absent in humans, compared with mice. PMID: 20007572
    28. IL-13Ralpha(345-354) (WLPFGFILI) induced a CD8(+) T-cell line that specifically produced IFN-gamma in response to HLA-A2+ T2 cells pulsed with the relevant peptide and lysed these cells. PMID: 12231526
    29. interleukin-13 receptor possibly plays an important part in the early inflammatory process of psoriasis; however, its function is lost in the psoriatic keratinocytes. PMID: 12445201
    30. IL-4/IL-13-induced IL-13Ralpha2 expression is potentiated by TNF-alpha PMID: 12485861
    31. The 5' flanking region of IL-13Ra2 has been isolated and cloned and the gene control region functionally characterized. PMID: 12816724
    32. The inhibitory effects of the IL-13 receptor alpha 2 subunit on IL-13 signaling are dependent on both the level of expression of the receptor and the concentration of IL-13. PMID: 16751396
    33. Immunohistochemical analyses revealed that 83% of ovarian cancer specimens express IL-13Ralpha2, whereas normal ovary samples expressed none or very low levels. PMID: 16902988
    34. data suggest that IL13RA2 gene polymorphisms may be involved in susceptibility to systemic sclerosis PMID: 16981293
    35. Highly variable expression of IL13Ralpha2 protein both within and across specimens of glioblastoma multiforme. PMID: 17804706
    36. IL-13Ralpha2 and Olig2 have been identified and confirmed to be interesting candidate genes whose differential expression likely plays a role in malignant progression of astrocytomas PMID: 17917751
    37. RasGRP4 translocates to varied intracellular compartments via its DAG/PMA-binding domain to regulate signaling pathways that control gene and protein expression in MCs, including the cell's ability to respond to IL-13. PMID: 18024961
    38. soluble form of IL-13Ralpha(2) may therefore modulate mucus overproduction by IL-13 through the pathway including IL-13Ralpha(1) in normal human bronchial epithelial cells PMID: 18028464
    39. IL-13R alpha 2, EphA2, and Fra-1 are attractive therapeutic targets representing molecular denominators of high-grade astrocytomas. One hundred percent of GBM tumors overexpress at least one of these proteins. PMID: 18172271
    40. 13Ralpha2 protein and mRNA are expressed to significantly higher levels in brainstem glioma than in normal brain tissue PMID: 18430795
    41. The feasibility of MRI to visualize different phases of immune response when IL-13Ralpha2-specific CTLs are administered directly to the glioma tumor bed. PMID: 18559603
    42. IL-13Ralpha2 is expressed by both primary bronchial epithelial cells and fibroblasts as an intracellular protein with a diffuse cytoplasmic distribution; in vivo, IL-13Ralpha2 is expressed in the airway mucosa mainly by bronchial epithelial cells PMID: 18564628
    43. analysis of cDNA clone and prokaryotic expression of human interleukin-13 receptor [alpha]2 chain PMID: 18677476
    44. study concludes that matrix metalloproteinase-8 cleaves IL-13R alpha 2 in vitro and contributes to the solubilization of IL-13R alpha 2 in vivo PMID: 18694590
    45. Hepatic stellate cells in sinusoidal lesions of liver from patients with nonalcoholic steatohepatitis express high levels of high-affinity IL-13R (IL-13 receptor alpha2), whereas fatty liver and normal liver specimens do not express IL-13Ralpha2. PMID: 18802068
    46. Human adrenomedullin up-regulates interleukin-13 receptor alpha2 chain in prostate cancer in vitro and in vivo. PMID: 19010904
    47. Cytokines IL-13Ralpha2, IL-4, IL-6, IL-8 and TNF-alpha may play roles in the pathogenesis of pediatric HSP/HSPN. PMID: 19149920
    48. Human and murine neuroendocrine pheochromocytoma overexpress the IL-13Ralpha2 chain, and an IL-13PE-based receptor-directed anticancer approach may prove useful in treatment for metastatic pheochromocytoma patients. PMID: 19491224
    49. IL-13Ralpha2 may serve as a prognostic biomarker of invasion and metastasis in pancreatic cancer. PMID: 19887609
    50. Humans only express the membrane bound form of the IL-13 receptor alpha 2 PMID: 18307523

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Type I cytokine receptor family, Type 5 subfamily
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 5975

    OMIM: 300130

    KEGG: hsa:3598

    STRING: 9606.ENSP00000243213

    UniGene: Hs.336046