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DUSP3 Antibody

  • 中文名稱：
    DUSP3兔多克隆抗體
  • 貨號：
    CSB-PA007255LA01HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時一口價
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA007255LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) DUSP3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Dual specificity phosphatase 3 antibody; Dual specificity protein phosphatase 3 antibody; Dual specificity protein phosphatase VHR antibody; DUS3_HUMAN antibody; DUSP3 antibody; Serine/threonine specific protein phosphatase antibody; Vaccinia H1-related phosphatase antibody; Vaccinia virus phosphatase VH1 related antibody; VHR antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Dual specificity protein phosphatase 3 protein (14-96AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，DUSP3 Antibody (CSB-PA007255LA01HU)，的標記方式是Non-conjugated。對于DUSP3 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA007255LB01HU DUSP3 Antibody, HRP conjugated ELISA
    FITC CSB-PA007255LC01HU DUSP3 Antibody, FITC conjugated
    Biotin CSB-PA007255LD01HU DUSP3 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.
  • 基因功能參考文獻：
    1. Nuclear HSP70 leads to enhancement of vaccinia H1-related phosphatase (VHR) activity via protein-protein interaction rather than its molecular chaperone activity, thereby suppressing excessive ERK activation. Downregulation of either VRK3 or HSP70 rendered cells vulnerable to glutamate-induced apoptosis. PMID: 27941812
    2. Data indicated that regulating non-receptor tyrosine kinase FAK and cell migration is a newly revealed function of VHR/DUSP3. PMID: 28759036
    3. The loss of DUSP3 activity markedly increases gamma radiation-induced DNA strand breaks, suggesting a potential novel role for DUSP3 in DNA repair. PMID: 28389334
    4. In PTP1B and VHR, two new allosteric clusters were identified in each enzyme. PMID: 28625849
    5. In the phosphatase-silenced cells, the normal bipolar spindle structure was restored by chemical inhibition of Erk1/2 and ectopic overexpression of Dusp3. We propose that at M phase Dusp3 keeps Erk1/2 activity in check to facilitate normal mitosis. PMID: 27423135
    6. Data suggest levels of gene expression of both DUSP3 (dual specificity phosphatase 3) and PSME3 (proteasome activator subunit 3) are associated with susceptibility to Staphylococcus aureus infection/sepsis in humans and in mouse disease model. PMID: 24901344
    7. Our results demonstrate that DUSP3 plays a key and nonredundant role as a regulator of innate immune responses PMID: 25876765
    8. VHR can dimerize inside cells, and that VHR catalytic activity is reduced upon dimerization. PMID: 24798147
    9. DUSP3 is a pro-angiogenic atypical dual-specificity phosphatase. PMID: 24886454
    10. DUSP3 interacting partners are nucleolar proteins involved in processes related to DNA repair and senescence. PMID: 24245651
    11. we report the first successful site-specific incorporation of sulfotyrisine into VHR through the use of expanding genetic code PMID: 23918168
    12. Proteins containing the class II motifs are efficient VHR substrates in vitro, suggesting that VHR may act on a novel class of yet unidentified Tyr(P) proteins in vivo. PMID: 23322772
    13. Enteric commensal bacteria induce extracellular signal-regulated kinase pathway signaling via formyl peptide receptor-dependent redox modulation of dual specific phosphatase 3 PMID: 21921027
    14. VHR expression enhances the signaling of ErbB receptors and may be involved in NSCLC pathogenesis. PMID: 21262974
    15. VHR, a Vaccinia virus VH1-related dual-specific protein phosphatase, is phosphorylated at Y138 by ZAP-70. PMID: 12447358
    16. VHR is required for cell-cycle progression as it modulates MAP kinase activation in a cell-cycle phase-dependent manner. PMID: 16604064
    17. deregulated expression of BRCA1-IRIS is likely to reduce dependence on normal physiological growth stimuli PMID: 17278098
    18. Small dual-specificity phosphatase VHR selectively dephosphorylates tyrosine-phosphorylated interferon-alpha- and beta-activated transcription factor STAT5, leading to the subsequent inhibition of STAT5 function. PMID: 17785772
    19. Results highlight the importance of a high intracellular Zn(2+) content and the VHR/ZAP-70/ERK1,2-associated pathways in the modulation of LNCaP prostate cancer cell growth. PMID: 18311544
    20. VHR can be considered as a new marker for cancer progression in cervix carcinoma and potential new target for anticancer therapy PMID: 18505570
    21. VHR has a direct role in the inhibition of JNK-dependent apoptosis in LNCaP cells and may therefore have a role in prostate cancer progression. PMID: 19010898

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3069

    OMIM: 600183

    KEGG: hsa:1845

    STRING: 9606.ENSP00000226004

    UniGene: Hs.181046