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DNAJB8 Antibody

  • 中文名稱：
    DNAJB8兔多克隆抗體
  • 貨號：
    CSB-PA836779LA01HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時一口價
  • 圖片：
    • Western blot
      All lanes: DNAJB8 antibody at 8µg/ml
      Lane 1: Hela whole cell lysate
      Lane 2: Mouse brain tissue
      Lane 3: Mouse liver tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 26 kDa
      Observed band size: 26 kDa
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA836779LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA836779LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：

    The DNAJB8 antibody is produced by immunizing rabbits with the recombinant human DNAJB8 protein (1-232AA) and then antigen-affinity-purified from rabbit antiserum. It occurs as an unconjugated IgG. It shows reactivity with human and mouse DNAJB8 protein, which plays a role in the suppression of toxic polyglutamine (poly Q) protein aggregation and in vivo tumor initiation. This DNAJB8 antibody has been validated for use in ELISA, WB, and IHC applications.

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) DNAJB8 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    DNAJB8
  • 別名：
    DJ6 antibody; DnaJ (Hsp40) homolog; subfamily B; member 8 antibody; DnaJ homolog subfamily B member 8 antibody; Dnajb8 antibody; DNJB8_HUMAN antibody; mDj6 antibody; MGC33884 antibody; OTTHUMP00000216243 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human DnaJ homolog subfamily B member 8 protein (1-232AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，DNAJB8 Antibody (CSB-PA836779LA01HU)，的標(biāo)記方式是Non-conjugated。對于DNAJB8 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA836779LB01HU DNAJB8 Antibody, HRP conjugated ELISA
    FITC CSB-PA836779LC01HU DNAJB8 Antibody, FITC conjugated
    Biotin CSB-PA836779LD01HU DNAJB8 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins.
  • 基因功能參考文獻(xiàn)：
    1. DNAJB8 is a central and versatile player in the protein aggregation and degradation system.DNAJB8 protein keeps Parkin C289G mutant protein in a soluble, degradation-competent form. PMID: 27713507
    2. Results show that DNAJB8 expression is induced by heat shock stress which increases side population cells and cancer stem-like cells. PMID: 29316077
    3. Taken together, the results indicate that DNAJB8 is expressed and has role in CRC CSC/CIC and that DNAJB8 is a novel target of CRC CSC/CIC-targeting immunotherapy. PMID: 24450541
    4. The mechanism of DNAJB6 and DNAJB8 is suppression of polyQ protein aggregation by directly binding the polyQ tract. PMID: 23612975
    5. Cancer stem-like cell (CSC) maintenance and that it offers a candidate for CSC-targeting immunotherapy in renal cell carcinoma PMID: 22552285
    6. DNAJB6b and DNAJB8 are superior suppressors of aggregation and toxicity of disease-associated polyglutamine proteins. PMID: 20159555

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  • 數(shù)據(jù)庫鏈接：

    HGNC: 23699

    OMIM: 611337

    KEGG: hsa:165721

    STRING: 9606.ENSP00000316053

    UniGene: Hs.518241