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CHI3L2 Antibody, Biotin conjugated

  • 中文名稱：
    CHI3L2兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA620893LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CHI3L2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    CH3L2_HUMAN antibody; CHI3L2 antibody; Chitinase 3 like 2 antibody; Chitinase-3-like protein 2 antibody; Chondrocyte protein 39 antibody; OTTHUMP00000014028 antibody; YKL 39 antibody; YKL-39 antibody; YKL39 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Chitinase-3-like protein 2 protein (27-390AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity.
  • 基因功能參考文獻(xiàn)：
    1. This study shown that CHI3L2 is regulated differently in healthy and late onset Alzheimer"s disease brain depending on the sex. PMID: 27653898
    2. Structural analysis demonstrates that YKL-39 interacts with chitooligosaccharides through hydrogen bonds and hydrophobic interactions. Thermodynamic analysis indicates that binding of chitooligosaccharide to YKL-39 is mainly driven by enthalpy. PMID: 25477513
    3. These data suggest that hYKL-39 is a novel growth and differentiation factor involved in cartilage homeostasis. PMID: 23291184
    4. YKL-39 possesses a chitinase-like fold, but lacks key active-site residues required for catalysis. PMID: 22742450
    5. ERK1/2 phosphorylation by CHI3L2 inhibits cell mitogenesis and proliferation. PMID: 22211103

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Glycosyl hydrolase 18 family
  • 組織特異性：
    Highest expression in chondrocytes, followed by synoviocytes, lung and heart. Not detected in spleen, pancreas, and liver. May also be expressed in developing brain and placenta.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1933

    OMIM: 601526

    KEGG: hsa:1117

    STRING: 9606.ENSP00000358763

    UniGene: Hs.514840