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CELSR1 Antibody

  • 中文名稱：
    CELSR1兔多克隆抗體
  • 貨號：
    CSB-PA982432
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Immunofluorescence analysis of MCF-7 cells, using CELSR1 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CELSR1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human CELSR1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:100-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Receptor that may have an important role in cell/cell signaling during nervous system formation.
  • 基因功能參考文獻：
    1. Patients with CELSR1 mutations and spina bifida can have significant renal malformations. PMID: 27597235
    2. This single-nucleotide polymorphism-by-sex genome-wide association analysis identified the fetal lung development gene, CELSR1, as a potential sex-specific risk factor for Chronic obstructive pulmonary disease. PMID: 27854507
    3. Upregulating CELSR1 expression significantly promoted cell growth, while knocking down CELSR1 inhibited the growth and decreased tube formation. PMID: 27301287
    4. Single nucleotide polymorphisms in nNOS, renalase, MTHFR, CELSR1 and XYLB genes were found significantly associated with ischemic stroke in Chinese patients. PMID: 25855559
    5. the present study has proven for the first time that CELSR1 is a susceptibility gene for ischaemic stroke in the Chinese Han population, especially for large artery atherosclerosis. PMID: 25117632
    6. CELSR1 mutations contribute to the risk of spina bifida in a cohort of spina bifida patients from California PMID: 24632739
    7. Celsr1 regulates dynamic cell movements by inhibiting stabilization of VE-cadherin and maturation of adherens junctions. PMID: 23792146
    8. CELSR1 is a risk factor for neural tube defects or caudal agenesis via pathogenic role of planar cell polarity signaling in these malformations. PMID: 22371354
    9. Missense variants in CELSR1 may represent a cause of craniorachischisis in humans, as in mice, with defective planar cell polarity protein trafficking to the plasma membrane a likely pathogenic mechanism. PMID: 22095531
    10. CELSR1 may have a role in ischemic stroke, as shown in a Portuguese case-control cohort PMID: 21511255
    11. The planar cell polarity genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis. PMID: 20223754
    12. Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study. PMID: 19403135
    13. exclusion as a candidate gene for schizophrenia-- a cadhrin gene PMID: 11807409
    14. Variations in the nine ectodomains of CELSR1 do not increase susceptibility to schizophrenia. PMID: 12782967

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  • 相關疾?。?/div>
    Neural tube defects (NTD)
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family, LN-TM7 subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1850

    OMIM: 182940

    KEGG: hsa:9620

    STRING: 9606.ENSP00000262738

    UniGene: Hs.252387