CCS Antibody
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中文名稱:CCS兔多克隆抗體
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貨號:CSB-PA004854LA01HU
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規(guī)格:¥440
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促銷:
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圖片:
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IHC image of CSB-PA004854LA01HU diluted at 1:400 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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其他:
產(chǎn)品詳情
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產(chǎn)品名稱:Rabbit anti-Homo sapiens (Human) CCS Polyclonal antibody
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Uniprot No.:
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基因名:CCS
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別名:CCS antibody; CCS_HUMAN antibody; Copper chaperone for superoxide dismutase antibody; MGC138260 antibody; SOD 4 antibody; SOD4 antibody; Superoxide dismutase copper chaperone antibody
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宿主:Rabbit
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反應(yīng)種屬:Human
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免疫原:Recombinant Human Copper chaperone for superoxide dismutase protein (145-274AA)
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Non-conjugated
本頁面中的產(chǎn)品,CCS Antibody (CSB-PA004854LA01HU),的標(biāo)記方式是Non-conjugated。對于CCS Antibody,我們還提供其他標(biāo)記。見下表:
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克隆類型:Polyclonal
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抗體亞型:IgG
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純化方式:>95%, Protein G purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA, IHC
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推薦稀釋比:
Application Recommended Dilution IHC 1:200-1:500 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點詳情
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功能:Delivers copper to copper zinc superoxide dismutase (SOD1).
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基因功能參考文獻(xiàn):
- In addition to Atox1, the human cytoplasm also contains Cu chaperones for loading of superoxide dismutase 1 (i.e. CCS) and cytochrome c oxidase in mitochondria (i.e. Cox17). [review] PMID: 26745464
- Human cytoplasmic copper chaperones Atox1 and CCS exchange copper ions in vitro PMID: 25673218
- Coexpression of hCCS in the presence of copper restores the correct maturation of the SOD1 mutants and prevents the formation of the unstructured species, confirming that hCCS also acts as a molecular chaperone. PMID: 25429517
- CCS mRNA and protein levels in the serum are not correlated with inflammatory processes. PMID: 24855044
- CTR1 silencing increased the protein levels of copper chaperone ATOX1 and copper chaperone for superoxide dismutase 1 (CCS-1), but decreased copper chaperone for cytochrome c oxidase (COX17). PMID: 24343031
- CCS1 serves as a specialized import receptor in mitochondria that facilitates the import and folding of SOD1 and CCS1. PMID: 24026195
- CCS-dependent copper acquisition and distribution largely occur at membrane interfaces and that this emerging role of the bilayer may reflect a general mechanistic aspect of cellular transition metal ion acquisition. PMID: 24297923
- CCS-1 facilitates copper trafficking to the mitochondria, but does not affect the transfer of copper to the cytochrome c oxidase. PMID: 23900152
- The CCS mutation, p.Arg163Trp, causes reduced SOD1 activity and may impair other mechanisms important for normal Cu homeostasis. PMID: 22508683
- analysis of human superoxide dismutase 1 (hSOD1) maturation through interaction with human copper chaperone for SOD1 (hCCS) PMID: 22869735
- Loss of copper chaperone for superoxide dismutase (CCS) increases amyloid-beta production in both CCS knockout neurons and CCS small-interfering (si)RNA-treated cultured tumor cells. PMID: 20693630
- The results of the present study reveal the plasticity of this multi-domain chaperone in solution and are consistent with an indispensable flexibility necessary for executing its dual functions of metal binding and transfer. PMID: 21722094
- CCS reduces, under non-oxidative conditions, yet facilitates in the presence of H(2)O(2), mitochondrial translocation of inactive SOD1 mutants. PMID: 21354101
- Results describe the identification of the copper chaperone for superoxide dismutase as a mediator of copper delivery to XIAP in cells. PMID: 20154138
- No causative mutations for amyotrophic lateral sclerosis (ALS) gene have been detected in the CCS gene in 20 sporadic ALS patients analyzed, but an intragenic single nucleotide polymorphism has been identified. PMID: 11991808
- Study of site-directed cysteine-to-serine mutants of CCS suggests the formation of a domain III copper cluster within a dimeric or tetrameric protein and further suggest that this cluster may be an important element of CCS copper transfer machinery. PMID: 15736924
- The copper chaperone CCS is responsible for copper insertion into apo-superoxide dismutasse 1. PMID: 16132821
- A mechanism determining the abundance of CCS that is competitive with the process of copper delivery to SOD1 is described, revealing a unique post-translational component of intracellular copper homeostasis. PMID: 16531609
- copper chaperone mRNA levels were reduced in peripheral mononuclear cells after copper supplementation PMID: 17683925
- Measurements of hCCS-induced SOD1 activation were used to show that the C-terminal CXC sequence is both necessary and sufficient for EZn-SOD maturation. PMID: 18393442
- copper chaperone for SOD1 (CCS) facilitates maturation of SOD1 and that CCS overexpression ameliorates intracellular aggregation of mutant SOD1 in vivo. PMID: 18552350
- data suggest that Cys residues in domain 2 of hCCS are involved in the formation, stability, and redox potential of the domain 3 cluster PMID: 19007184
- Incomplete posttranslational modification of nascent superoxide dismutase (SOD)1 polypeptides via trasnsgenic SOD1 copper chaperone (CCS) may be a characteristic shared by familial SOD1 mutants in amyotrophic lateral sclerosis. PMID: 19227972
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亞細(xì)胞定位:Cytoplasm.
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蛋白家族:Cu-Zn superoxide dismutase family
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組織特異性:Ubiquitous.
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數(shù)據(jù)庫鏈接:
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