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Actb Antibody, Biotin conjugated

  • 中文名稱：
    Actb兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA07675D0Rb
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Mus musculus (Mouse) Actb Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    Actb
  • 別名：
    ActbActin antibody; cytoplasmic 1 antibody; Beta-actin) [Cleaved into: Actin antibody; cytoplasmic 1 antibody; N-terminally processed] antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Mouse
  • 免疫原：
    Recombinant Mouse Actin, cytoplasmic 1 protein (11-375AA)
  • 免疫原種屬：
    Mus musculus (Mouse)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.
  • 基因功能參考文獻：
    1. Data, including data from studies using knockout mice, suggest that Actb and Actg1 are enriched in isolated membrane preparations from skeletal muscle which represent interface between mitochondria and sarco-endoplasmic reticulum; these structures appear to be important in signaling, mitochondrial dynamics, and muscle relaxation. (Actb = beta actin cytoplasmic 1; Actg1 = actin gamma cytoplasmic 1) PMID: 29265728
    2. Essential nucleotide- and protein-dependent functions of Actb/beta-actin. PMID: 30012594
    3. These results suggest a a novel genome-wide mechanism where the polymerase-associated beta-actin synergizes with NM1 to coordinate permissive chromatin with Pol I transcription, cell growth, and proliferation. PMID: 27127100
    4. Two actin isoforms, beta- and gamma-actin, are crucial for slow, rapid, bulk, and overshoot endocytosis at large calyx-type synapses, and for slow endocytosis and bulk endocytosis at small hippocampal synapses. PMID: 27840001
    5. Melatonin treatment for 1 h increased monomeric actin and decreased polymeric actin. PMID: 28209510
    6. Disruption of the in vivo interaction of KIF11 with ZBP1 delocalizes beta-actin mRNA and affects cell migration. PMID: 25588836
    7. TIA proteins can function as long-term regulators of the ACTB mRNA metabolism in mouse and human cells. PMID: 24766723
    8. Actin binding proteins associated with stress fiber or focal adhesion formation are overexpressed in the beta-actin knock-out cells and many of these contain CH-, LIM- or EFh- domains. PMID: 24123846
    9. Absence of beta-actin severely hampers formation of the peripheral nervous system, due to defective neural crest migration. PMID: 24409333
    10. Data indicate that ectopic phosphatidylinositol 3,4,5-triphosphate (PIP3) elevation alone activated membranes to form actin-based structures whose behavior was similar to that of growth-cone-like "waves". PMID: 23951027
    11. this work demonstrated that dendritic beta-actin messenger RNA and ribosomes are in a masked, neuron-specific form. PMID: 24458642
    12. chorein interacts with beta-adducin and beta-actin. PMID: 24129186
    13. RNA polymerase II, glyceraldehyde-3-phosphate dehydrogenase (Gapdh), and hypoxanthine phophoribosyltransferase (Hprt) show a more stable gene expression as candidate genes than do ribosomal 18s and Actb. PMID: 22735032
    14. The findings suggested that local translation of beta-actin in growth cones of motoneurons is regulated by laminin signalling and that this signalling is disturbed in survival of motoneuron protein-deficient motoneurons. PMID: 22810847
    15. Data suggest that in beta-actin knockout cells other actins compensate for beta-actin in cell migration process. PMID: 22448045
    16. Data indicate that Ubc and Ywhaz were best correlated for B cells and lymphocytes, whereas Ubc and Gapdh were the best combination for non-B cells, and Actb and Hprt1 were the least stably expressed genes for B cells and non-B cell. PMID: 22884776
    17. the zipcode-binding protein 1 transports beta-actin mRNA to the focal adhesion compartment, it dwells for minutes, associating its localization with motility through the formation of stable connections between adhesions and newly synthesized actin filaments PMID: 22948660
    18. These data show that thymosinbeta4 and beta-actin are over-expressed during nurse cell formation upon T. spiralis infection and may be involved in nurse cell formation along with other actin-binding proteins. PMID: 22305657
    19. novel roles for beta-actin in promoting complex CNS tissue architecture PMID: 22403730
    20. Beta- and gamma-cytoplasmic actins are required for meiosis in mouse oocytes. PMID: 21778137
    21. These data support an essential role for beta-actin in regulating cell migration and gene expression through control of the cellular G-actin pool PMID: 21900491
    22. Perturbing the dystrophin and beta actin interaction results in quadriceps myopathy. PMID: 21325027
    23. Nuclear beta-actin controls growth arrest of epithelial cells. PMID: 21172822
    24. Results demonstrate overlapping developmental roles but unique post-developmental functions for beta-actin and gamma-actin in maintaining hair cell stereocilia. PMID: 20976199
    25. Data show that exposure to hyperoxia resulted in significant increases in eNOS-beta-actin association, eNOS activity, and protein tyrosine nitration in the lungs. PMID: 20826796
    26. arginylated gamma-actin, unlike beta-, was highly unstable and selectively ubiquitinated and degraded in vivo; instability was regulated by differences in nucleotide coding sequence between the actin isoforms, which conferred different translation rates PMID: 20847274
    27. HnRNP-R-mediated axonal beta-actin mRNA translocation plays an essential physiological role for axon growth and presynaptic differentiation. PMID: 20167579
    28. Dystrophin and utrophin bind actin through distinct modes of contact PMID: 16478721
    29. beta-actin was arginylated in vivo to regulate actin filament properties, beta-actin localization, and lamella formation in motile cells PMID: 16794040
    30. Data show that beta-actin characteristic markers of brush borders, become abnormally distributed along these atypical basolateral membranes in gal3(-/-) mice. PMID: 18211959
    31. The cytoplasmic beta-actin (Actb) gene generates two alternative transcripts terminated at tandem polyA sites. PMID: 18835850
    32. Ischemia-mediated aggregation of the actin cytoskeleton is one of the major initial events resulting in ischemia-reperfusion injury. PMID: 19095765

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  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Nucleus.
  • 蛋白家族：
    Actin family
  • 組織特異性：
    Expressed in the epididymis (at protein level). Expressed in the kidney (at protein level).
  • 數(shù)據(jù)庫鏈接：