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ATXN7L3 Antibody, FITC conjugated

  • 中文名稱：
    ATXN7L3兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA613538LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ATXN7L3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ATXN7L3
  • 別名：
    AT7L3_HUMAN antibody; Ataxin 7 like 3 antibody; Ataxin 7 like protein 3 antibody; Ataxin-7-like protein 3 antibody; atxn7l3 antibody; SAGA associated factor 11 homolog antibody; SAGA-associated factor 11 homolog antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Ataxin-7-like protein 3 protein (51-347AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B.
  • 基因功能參考文獻(xiàn)：
    1. Downregulation of ATXN7L3 by short hairpin RNA speci fi cally inactivated the SAGA deubiquitination activity, leading to a strong increase of global H2B ubiquitination and a moderate increase of H2A ubiquitination. PMID: 21746879
    2. The solution structures of the SCA7 domain of both ATXN7 and ATXN7L3 reveal a new, common zinc-finger motif at the heart of two distinct folds, providing a molecular basis for the observed functional differences. PMID: 20634802
  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    SGF11 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 25416

    KEGG: hsa:56970

    STRING: 9606.ENSP00000397259

    UniGene: Hs.512651