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ATXN1L Antibody, Biotin conjugated

  • 中文名稱：
    ATXN1L兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA002440LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ATXN1L Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ATXN1L
  • 別名：
    ATXN1L antibody; BOAT antibody; BOAT1Ataxin-1-like antibody; Brother of ataxin-1 antibody; Brother of ATXN1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Ataxin-1-like protein (183-463AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development.
  • 基因功能參考文獻(xiàn)：
    1. The ATXN1L-CIC-ETS transcription factor axis as a mediator of resistance to MAPKi. PMID: 28178529
    2. Both ATXN1 and BOAT1 bind to the promoter region of Hey1 and inhibit the transcriptional output of Notch through direct interactions with CBF1, a transcription factor that is crucial for the Notch pathway. PMID: 21475249
    3. Boat is an in vivo binding partner of ataxin-1 whose altered expression in Purkinje cells may contribute to their degeneration in causes spinocerebellar ataxia type 1 animals PMID: 16121196
  • 亞細(xì)胞定位：
    Nucleus. Cell projection, dendrite. Note=Forms nuclear foci. Colocalizes with NCOR2 and HDAC3. Distributed beyond the nucleus into the cell body and dendrites in Purkinje cells and in inferior olive cells.
  • 蛋白家族：
    ATXN1 family
  • 組織特異性：
    Expressed in cerebellum and cerebral cortex.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 33279

    OMIM: 614301

    KEGG: hsa:342371

    STRING: 9606.ENSP00000415822

    UniGene: Hs.743239