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ATG4C Antibody

  • 中文名稱：
    ATG4C兔多克隆抗體
  • 貨號(hào)：
    CSB-PA732174
  • 規(guī)格：
    ￥880
  • 圖片：
    • Immunohistochemical analysis of paraffin-embedded Human Skeletal Muscle Tissue using ATG4c Rabbit pAb diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded Human Brain Tissue using ATG4c Rabbit pAb diluted at 1:200
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    APG4 autophagy 4 homolog C (S. cerevisiae) antibody; APG4 autophagy 4 homolog C antibody; APG4 C antibody; APG4-C antibody; APG4C antibody; ATG 4C antibody; ATG4 autophagy related 4 homolog C (S. cerevisiae) antibody; ATG4 autophagy related 4 homolog C antibody; Atg4c antibody; ATG4C_HUMAN antibody; AUT (S. cerevisiae) like 1; cysteine endopeptidase antibody; AUT like 1; cysteine endopeptidase (S. cerevisiae) antibody; AUT like 1; cysteine endopeptidase antibody; AUT like 3 cysteine endopeptidase antibody; AUT-like 3 cysteine endopeptidase antibody; AUTL1 antibody; AUTL3 antibody; Autophagin 3 antibody; Autophagin-3 antibody; Autophagy related 4C cysteine peptidase antibody; Autophagy related cysteine endopeptidase 3 antibody; Autophagy related protein 4 homolog C antibody; Autophagy-related cysteine endopeptidase 3 antibody; Autophagy-related protein 4 homolog C antibody; Cysteine protease ATG4C antibody; EC 3.4.22 antibody; FLJ14867 antibody; OTTHUMP00000010715 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Recombinant Protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 純化方式：
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
    ELISA 1:10000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
  • 基因功能參考文獻(xiàn)：
    1. association between SNPs and Kashin-Beck disease PMID: 27742532
    2. We demonstrate that, in breast cancer cells, ATM and ATG4C are essential drivers of mammosphere formation, suggesting that their targeting may improve current approaches to eradicate breast cancer cells with a stem-like phenotype. PMID: 28423511
    3. miR-376b controls autophagy by directly regulating intracellular levels of two key autophagy proteins, ATG4C and BECN1. PMID: 22248718
  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peptidase C54 family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 16040

    OMIM: 611339

    KEGG: hsa:84938

    STRING: 9606.ENSP00000322159

    UniGene: Hs.7353