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ASIC3 Antibody

  • 中文名稱：
    ASIC3兔多克隆抗體
  • 貨號：
    CSB-PA890688ESR1HU
  • 規(guī)格：
    ￥440
  • 促銷：
    小規(guī)格抗體限時一口價
  • 圖片：
    • Western blot
      All lanes: ASIC3 antibody at 2.4µg/ml
      Lane 1: Jurkat whole cell lysate
      Lane 2: HepG2 whole cell lysate
      Lane 3: Hela whole cell lysate
      Lane 4: A549 whole cell lysate
      Lane 5: A431 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 59, 61, 45 kDa
      Observed band size: 59 kDa
    • Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA890688ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA890688ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ASIC3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    ACCN 3 antibody; Accn3 antibody; ACCN3_HUMAN antibody; Acid sensing ion channel 3 antibody; Acid-sensing ion channel 3 antibody; Amiloride sensitive cation channel 3 antibody; Amiloride sensitive cation channel 3 testis antibody; Amiloride-sensitive cation channel 3 antibody; ASIC 3 antibody; ASIC3 antibody; DRASIC antibody; hASIC 3 antibody; hASIC3 antibody; hTNaC 1 antibody; hTNaC1 antibody; Modulatory subunit of ASIC 2a antibody; Modulatory subunit of ASIC2a antibody; Neuronal amiloride sensitive cation channel 3 antibody; Neuronal amiloride-sensitive cation channel 3 antibody; Proton gated cation channel subunit antibody; SLNAC 1 antibody; SLNAC1 antibody; Testis sodium channel 1 antibody; TNaC 1 antibody; TNaC1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Acid-sensing ion channel 3 protein (62-320AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.
  • 基因功能參考文獻：
    1. The present review discusses the dual nature of ASIC3 in joint inflammation with possible mechanisms. PMID: 30035658
    2. Acidic pH resulted in an increase in ASIC-3 expressionin the discs of paitents with intervertebral disc degeneration. PMID: 27853274
    3. the data demonstrate a functional link between ASICs and [Ca(2+)]i/RhoA pathway, which contributes to the acidity-induced epithelial-mesenchymal transition. PMID: 28518134
    4. Respiratory syncytial virus and measles virus infection upregulates ASICS3 expression in bronchial epithelial cells. PMID: 28187208
    5. The results show that acid-sensing ion channel 1, acid-sensing ion channel 2, and acid-sensing ion channel 3 are expressed in A549 cells at the messenger RNA and protein levels, and acid-sensing ion channel-like currents were elicited by extracellular acid stimuli. PMID: 28618956
    6. Blocking ASIC3 in interneurons from temporal lobe epilepsy patients decreased the frequency of action potential firing. PMID: 25476599
    7. These findings open new perspectives on the roles of ASIC3 in the absence of tissue pH variation, as well as on the contribution of those channels to lipid-mediated signaling. PMID: 26772186
    8. This study suggests that ASIC23may play a role as mediators of inflammatory pain and be involved in the pathogenesis of frozen shoulder. PMID: 26033064
    9. Sea anemone peptide with uncommon beta-hairpin structure inhibits acid-sensing ion channel 3 (ASIC3) and reveals analgesic activity. PMID: 23801332
    10. Experiments with Asic3 inhibitors show that Asic3 inhibition leads to loss of pressure-induced vasodilation due to pressure detection failure rather than endothelial mechanisms. PMID: 22842475
    11. The highly proton sensitive ASIC3 channels are predominantly distributed in peripheral sensory neurons, correlating with their roles in multimodal sensory perception, including nociception, mechanosensation, and chemosensation. PMID: 22778854
    12. CAR and ASIC3 co-immunoprecipitate only when co-expressed with PSD-95. PMID: 22809504
    13. Lignan from thyme possesses inhibitory effect on ASIC3 channel current. PMID: 22854960
    14. ASIC3 is able to sense the extracellular pH in both directions and to dynamically adapt its activity between pH 5.0 and 8.0, playing a role in fine tuning neuronal membrane potentials and neuron sensitization in various pH environments. PMID: 22829666
    15. The results showed that there was a significant increase in the mean relative optical density of ASIC2 and ASIC3 but not ASIC1a in the lining epithelium and glandular tubes of gastric mucosa in patients with Henoch-Schonlein purpura. PMID: 22157923
    16. Atomic level characterization of the nonproton ligand-sensing domain of ASIC3 channels. PMID: 21586569
    17. The biological features of ASIC3 is discussed and recent advances on the role of ASIC3 in the pathogenesis and treatment of arthritis pain, are summarized. PMID: 19885742
    18. Used coincidentally by sensory neurons to detect lactic acidosis, ASIC3 (amiloride-sensitive cation channel 3) interacts with adenosine triphosphate (ATP) to detect muscle ischemia. PMID: 21092862
    19. Neither ASIC3 or ASIC1 knockout influences the development or maintenance of experimental neuropathic pain after nerve injury. PMID: 20693874
    20. an independent association between an ASIC3 genetic polymorphism and insulin resistance in Taiwanese PMID: 20416288
    21. role in modulating high-intensity pain stimuli PMID: 12060708
    22. PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current PMID: 15317815
    23. Diclofenac studies show ASIC3 is a significant contributor to cutaneous acid-induced pain. PMID: 15574747
    24. the interaction of ASIC3 and CFTR may contribute to defective salt and fluid transepithelial transport in the cystic fibrotic pulmonary system PMID: 17012229
    25. These results suggest that the ASIC3 may be involved in blood pressure regulation. PMID: 18854755

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Cytoplasm.
  • 蛋白家族：
    Amiloride-sensitive sodium channel (TC 1.A.6) family, ASIC3 subfamily
  • 組織特異性：
    Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 101

    OMIM: 611741

    KEGG: hsa:9311

    STRING: 9606.ENSP00000297512

    UniGene: Hs.647113