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ARHGAP5 Antibody

  • 中文名稱(chēng)：
    ARHGAP5兔多克隆抗體
  • 貨號(hào)：
    CSB-PA564021
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA564021(ARHGAP5 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA564021(ARHGAP5 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Arhgap5 antibody; p190-B antibody; RHG05_HUMAN antibody; Rho GTPase activating protein 5 antibody; Rho GTPase-activating protein 5 antibody; Rho-type GTPase-activating protein 5 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human ARHGAP5
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    GTPase-activating protein for Rho family members.
  • 基因功能參考文獻(xiàn)：
    1. only collagen-IV elicits the formation of proteolytically active podosomes through a mechanism involving increased Src phosphorylation, p190RhoGAP-B (also known as ARHGAP5) relocalisation and MT1-MMP (also known as MMP14) cell surface exposure at podosome sites. PMID: 27231093
    2. Brazilian Amerindian ancestry compared to Asian, European, and African Genomes.SNPs within or proximal to CIITA (rs6498115), SMC6 (rs1834619), and KLHL29 (rs2288697) were most differentiated in the Amerindian-specific branch. SNPs in ADAMTS9 (rs7631391), DOCK2 (rs77594147), SLC28A1 (rs28649017), ARHGAP5 (rs7151991), and CIITA (rs45601437) in the Asian comparison. PMID: 28100790
    3. This newly identified miR-744/ARHGAP5 pathway provides further insight into the progression and metastasis of NPC and indicates potential novel therapeutic targets for NPC. PMID: 25961434
    4. Ectopic expression of p190B suppressed the miR-494-induced EGFR upregulation. PMID: 24316134
    5. The expression level of miR-486-5p was inversely correlated with that of ARHGAP5. PMID: 23474761
    6. RhoA is down-regulated at cell-cell contacts via p190RhoGAP-B in response to tensional homeostasis. PMID: 23552690
    7. Data indicate a role for p120-catenin (amino acids 820-843) domain in the p120-catenin.p190RhoGAP signaling complex assembly and membrane targeting. PMID: 23653363
    8. A cell cycle-regulated reduction in endogenous p190 levels is linked to completion of cytokinesis and generation of viable cell progeny. PMID: 14610059
    9. precise control of p190-B Rho GTPase-activating protein activity is critical for normal branching morphogenesis during mammary gland development PMID: 16469769
    10. Results link Cdk5 to Rho-ROCK signaling via Src and p190RhoGAP and implicate Cdk5 in the regulation of cell contraction, attachment, and migration. PMID: 19822667

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  • 亞細(xì)胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein.
  • 組織特異性：
    Detected in skin fibroblasts (at protein level).
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 675

    OMIM: 602680

    KEGG: hsa:394

    STRING: 9606.ENSP00000371897

    UniGene: Hs.592313