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ANAPC5 Antibody

  • 中文名稱：
    ANAPC5兔多克隆抗體
  • 貨號：
    CSB-PA952266
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA952266(ANAPC5 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA952266(ANAPC5 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    2510006G12Rik antibody; AA408751 antibody; AA536819 antibody; AA986414 antibody; ANAPC 5 antibody; ANAPC5 antibody; Anaphase promoting complex subunit 5 antibody; Anaphase-promoting complex subunit 5 antibody; Apc 5 antibody; APC5 antibody; APC5_HUMAN antibody; Cyclosome subunit 5 antibody; PDL 108 antibody; PDL108 antibody; Periodontal ligament fibroblast protein antibody; RMC1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human ANAPC5
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
  • 基因功能參考文獻(xiàn)：
    1. coexpression of APC5 and Axin genes significantly downregulated Wnt signaling in human SW480 CRC cells and inhibited cell growth. PMID: 28731177
    2. Results show that Apc5 binds the poly(A) binding protein (PABP), which directly binds the internal ribosome entry site (IRES) element of platelet-derived growth factor 2 mRNA. PMID: 15082755
    3. APC5 and APC7 suppress E1A-mediated transformation in a CBP/p300-dependent manner, indicating that these components of the APC/C may be targeted during cellular transformation PMID: 16319895
  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族：
    APC5 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 15713

    OMIM: 606948

    KEGG: hsa:51433

    STRING: 9606.ENSP00000261819

    UniGene: Hs.7101