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ACOX1 Antibody

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  • 中文名稱：
    ACOX1兔多克隆抗體
  • 貨號：
    CSB-PA110823
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA110823(ACOX1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA110823(ACOX1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Mouse stomach tissue, Mouse liver tissue, Mouse kidney tissue, Primary antibody: CSB-PA110823(ACOX1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    ACOX antibody; ACOX1 antibody; ACOX1_HUMAN antibody; Acyl CoA oxidase 1 palmitoyl antibody; Acyl CoA oxidase straight chain antibody; AOX antibody; EC 1.3.3.6 antibody; PALMCOX antibody; Palmitoyl CoA oxidase antibody; Palmitoyl-CoA oxidase antibody; Peroxisomal acyl coenzyme A oxidase 1 antibody; Peroxisomal acyl-coenzyme A oxidase 1 antibody; Peroxisomal fatty acyl CoA oxidase antibody; SCOX antibody; Straight chain acyl CoA oxidase antibody; Straight-chain acyl-CoA oxidase antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human ACOX1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:15-1:50
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評價

靶點詳情

  • 功能：
    Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. First enzyme of the fatty acid beta-oxidation pathway.; Shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length.; Is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Is twice as active as isoform 1 against 16-hydroxy-palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl-CoA.
  • 基因功能參考文獻：
    1. Because patients with AOx deficiency suffer from more severe symptoms than those with X-ALD, accumulation of VLC-PUFA and/or reduction of DHA may be associated with the severity of peroxisomal diseases. PMID: 24418004
    2. ACOX1 and GNPAT silencing up-regulated ceramide galactosyltransferase (UGT8) mRNA expression, and down-regulated UDP-glucoseceramide glucosyltransferase (UGCG). PMID: 23933200
    3. Data show that human ACOX1b isoform is more effective than the ACOX1a isoform in reversing the Acox1 null phenotype in the mouse. PMID: 20195242
    4. Mutational spectrum of peroxisomal acyl-coenzyme A oxidase deficiency. PMID: 17458872
    5. report on two new patients with ACOX1 deficiency and mutational analyses PMID: 18536048

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  • 相關(guān)疾病：
    Adrenoleukodystrophy, pseudoneonatal (Pseudo-NALD)
  • 亞細胞定位：
    Peroxisome.
  • 蛋白家族：
    Acyl-CoA oxidase family
  • 組織特異性：
    Widely expressed with highest levels of isoform 1 and isoform 2 detected in testis. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 levels are higher in brain, lung, muscle, white adipose tissue and testis. Level
  • 數(shù)據(jù)庫鏈接：

    HGNC: 119

    OMIM: 264470

    KEGG: hsa:51

    STRING: 9606.ENSP00000293217

    UniGene: Hs.464137